ICD-10-CM Code Q99.8

Other specified chromosome abnormalities

Version 2020 Billable Code POA Exempt

Valid for Submission

Q99.8 is a billable code used to specify a medical diagnosis of other specified chromosome abnormalities. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code Q99.8 might also be used to specify conditions or terms like 49,xxxyy syndrome, abnormal spermatogenesis, acute myeloid leukemia with cebpa somatic mutations, acute myeloid leukemia with inv; rpn1-evi1, acute myeloid leukemia with npm1 somatic mutation, additional sex chromosome, etc The code is exempt from present on admission (POA) reporting for inpatient admissions to general acute care hospitals.

ICD-10:Q99.8
Short Description:Other specified chromosome abnormalities
Long Description:Other specified chromosome abnormalities

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code Q99.8 are found in the index:


Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • 49,XXXYY syndrome
  • Abnormal spermatogenesis
  • Acute myeloid leukemia with CEBPA somatic mutations
  • Acute myeloid leukemia with inv; RPN1-EVI1
  • Acute myeloid leukemia with NPM1 somatic mutation
  • Additional sex chromosome
  • Anomaly of chromosome pair
  • Anomaly of chromosome X
  • Anomaly of chromosome Y
  • Anomaly of sex chromosome
  • Apparent mineralocorticoid excess
  • Ataxia-telangiectasia-like disorder
  • Atypical Norrie disease due to monosomy Xp11.3
  • Autosomal aneuploidy
  • Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation
  • Azoospermia
  • Biallelic RPE65 mutation associated retinal dystrophy
  • Centromeric instability of chromosomes 1,9 and 16 and immunodeficiency
  • Chimera
  • CHMP2B-related frontotemporal dementia
  • Chromosomal alterations of group A
  • Chromosomal alterations of group B
  • Chromosomal alterations of group C and X
  • Chromosomal alterations of group D
  • Chromosomal alterations of group E
  • Chromosomal alterations of group F
  • Chromosomal alterations of group G and Y
  • Chromosome 18 syndromes and antibody deficiency
  • Chromosome 22 abnormalities with hypogammaglobulinemia
  • Chromosome Xq27.3q28 duplication syndrome
  • Combined heterozygous low density lipoprotein receptor co-occurrent with low density lipoprotein receptor adaptor protein 1 mutations
  • Combined immunodeficiency due to OX40 deficiency
  • Congenital cleft larynx
  • Congenital leptin deficiency
  • Deletion of X-chromosome and hypogammaglobulinemia
  • DNA instability syndrome
  • Duplication of chromosome
  • Emanuel syndrome
  • Emberger syndrome
  • Epigenetic disorder
  • Extra unidentified structurally abnormal chromosome
  • Familial cardiomyopathy
  • Familial dilated cardiomyopathy with conduction defect due to LMNA mutation
  • Familial hypercholesterolemia
  • Familial hypercholesterolemia
  • Familial hypercholesterolemia due to heterozygous LDL receptor mutation
  • Familial hypercholesterolemia due to homozygous LDL receptor mutation
  • Frontotemporal dementia
  • Genetic short QT syndrome
  • Group chromosomal alteration
  • Gynandromorphism syndrome
  • Hereditary disorder by system
  • Hereditary disorder of musculoskeletal system
  • Hereditary hemoglobinopathy due to globin chain mutation
  • Hereditary retinal dystrophy primarily involving retinal pigment epithelium
  • Heritable pulmonary arterial hypertension
  • Heritable pulmonary arterial hypertension due to ALK1 or endoglin mutation
  • Heterologous chimera
  • Homologous chimera
  • Hypertension due to gain-of-function mutation in mineralocorticoid receptor
  • Hypospadias, penile
  • Imprinting error
  • Interleukin-1 receptor-associated kinase 4 deficiency
  • Isochromosomy Yp
  • Isochromosomy Yq
  • Isologous chimera
  • Lissencephaly due to TUBA1A mutation
  • Low density lipoprotein receptor adaptor protein 1 mutation
  • Low density lipoprotein receptor mutation
  • Male infertility of chromosomal origin
  • Male infertility of chromosomal origin
  • Male infertility of chromosomal origin
  • Male infertility with azoospermia due to single gene mutation
  • Male infertility with oligozoospermia due to single gene mutation
  • Male infertility with teratozoospermia due to single gene mutation
  • Maternal imprinting error
  • Maternal uniparental disomy of chromosome 1
  • Maternal uniparental disomy of chromosome 13
  • Maternal uniparental disomy of chromosome 16
  • Maternal uniparental disomy of chromosome 2
  • Maternal uniparental disomy of chromosome 20
  • Maternal uniparental disomy of chromosome 4
  • Maternal uniparental disomy of chromosome 6
  • Maternal uniparental disomy of chromosome 9
  • Megakaryoblastic acute myeloid leukemia with t
  • Mendelian disorders
  • Microduplication Xp11.22p11.23 syndrome
  • Mosaic variegated aneuploidy syndrome
  • Oligozoospermia
  • Opitz-Frias syndrome
  • Partial chromosome Y deletion
  • Partial tetrasomy 9 syndrome
  • Paternal imprinting error
  • Paternal uniparental disomy of chromosome 1
  • Paternal uniparental disomy of chromosome 13
  • Paternal uniparental disomy of chromosome 20
  • Paternal uniparental disomy of chromosome 21
  • Paternal uniparental disomy of chromosome 5
  • Paternal uniparental disomy of chromosome 6
  • Paternal uniparental disomy of chromosome 7
  • Poly Y syndrome
  • Polygenic hereditary disorder
  • Radiation chimera
  • Recombinant chromosome 8 syndrome
  • Sex chromosome aneuploidy
  • Sex-linked hereditary disorder
  • Short QT syndrome
  • Sperm morphology - finding
  • Susceptibility to respiratory infection associated with CD8alpha chain mutation
  • Syndromic X-linked intellectual disability due to JARID1C mutation
  • Teratozoospermia
  • Tetrasomy 11q24.1
  • Tetrasomy 12p
  • Tetrasomy 18p
  • Tetrasomy 21
  • Tetrasomy 5p
  • Tetrasomy 9p syndrome
  • Unbalanced translocation and insertion
  • Unbalanced translocation of chromosome
  • Uniparental disomy
  • Uniparental disomy of maternal origin
  • Uniparental disomy of paternal origin
  • X small rings
  • X-linked hereditary disease
  • Xq12-q13.3 duplication syndrome

Diagnostic Related Groups

The ICD-10 code Q99.8 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2019 through 09/30/2020.

  • 729 - OTHER MALE REPRODUCTIVE SYSTEM DIAGNOSES WITH CC/MCC
  • 730 - OTHER MALE REPRODUCTIVE SYSTEM DIAGNOSES WITHOUT CC/MCC

Present on Admission (POA)

Q99.8 is exempt from POA reporting - The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement. Review other POA exempt codes here .

CMS POA Indicator Options and Definitions
POA Indicator CodePOA Reason for CodeCMS will pay the CC/MCC DRG?
YDiagnosis was present at time of inpatient admission.YES
NDiagnosis was not present at time of inpatient admission.NO
UDocumentation insufficient to determine if the condition was present at the time of inpatient admission.NO
WClinically undetermined - unable to clinically determine whether the condition was present at the time of inpatient admission.YES
1Unreported/Not used - Exempt from POA reporting. NO

Convert Q99.8 to ICD-9

  • 758.81 - Oth cond due to sex chrm (Approximate Flag)
  • 758.89 - Oth con d/t chrm anm NEC (Approximate Flag)

Code Classification

  • Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
    • Chromosomal abnormalities, not elsewhere classified (Q90-Q99)
      • Other chromosome abnormalities, not elsewhere classified (Q99)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Genetic Disorders

Genes are the building blocks of heredity. They are passed from parent to child. They hold DNA, the instructions for making proteins. Proteins do most of the work in cells. They move molecules from one place to another, build structures, break down toxins, and do many other maintenance jobs.

Sometimes there is a mutation, a change in a gene or genes. The mutation changes the gene's instructions for making a protein, so the protein does not work properly or is missing entirely. This can cause a medical condition called a genetic disorder.

You can inherit a gene mutation from one or both parents. A mutation can also happen during your lifetime.

There are three types of genetic disorders:

  • Single-gene disorders, where a mutation affects one gene. Sickle cell anemia is an example.
  • Chromosomal disorders, where chromosomes (or parts of chromosomes) are missing or changed. Chromosomes are the structures that hold our genes. Down syndrome is a chromosomal disorder.
  • Complex disorders, where there are mutations in two or more genes. Often your lifestyle and environment also play a role. Colon cancer is an example.

Genetic tests on blood and other tissue can identify genetic disorders.

NIH: National Library of Medicine


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