2026 ICD-10-CM Diagnosis Code I68.0Cerebral amyloid angiopathy

ICD-10-CM Codes›I00–I99›I60-I69›I68

ICD-10-CM I68.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

I68.0 is a billable ICD-10-CM diagnosis code for cerebral amyloid angiopathy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is a manifestation code that cannot be reported as the principal diagnosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other and ill-defined cerebrovascular disease.

Code Identity

ICD-10-CM Code
I68.0
Billable Status
Yes — Valid for Submission
Code Describes
Cerebral amyloid angiopathy
Short Description
Cerebral amyloid angiopathy
Same as the full description in the CMS dataset.
Parent Code
I68
Cerebrovascular disorders in diseases classified elsewhere

Code Classification

ChapterI00–I99Diseases of the circulatory system
SectionI60-I69Cerebrovascular diseases
CategoryI68Cerebrovascular disorders in diseases classified elsewhere
This CodeI68.0Cerebral amyloid angiopathy

Code EditsBilling

Medicare Code Editor checks that affect claim validity for I68.0.

Manifestation diagnoses
Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and therefore should not be used as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Cerebral amyloid angiopathy
  • Cerebral amyloid angiopathy associated with systemic amyloidosis
  • Cerebral non-neuropathic heredofamilial amyloidosis angiopathy
  • Cerebral secondary systemic amyloid angiopathy
  • Familial non-neuropathic amyloidosis
  • Hereditary cerebral hemorrhage with amyloidosis
  • Hereditary cerebrovascular amyloidosis
  • Localized hereditary amyloidosis
  • Secondary systemic amyloidosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Code First

  • underlying amyloidosis E85

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR CIR024
Other and ill-defined cerebrovascular disease
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Amyloid Neuropathies, Familial

    inherited disorders of the peripheral nervous system associated with the deposition of amyloid in nerve tissue. the different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (prealbumin); apolipoprotein a-i; and gelsolin.

  • Cerebral Amyloid Angiopathy

    a heterogeneous group of sporadic or familial disorders characterized by amyloid deposits in the walls of small and medium sized blood vessels of cerebral cortex and meninges. clinical features include multiple, small lobar cerebral hemorrhage; cerebral ischemia (brain ischemia); and cerebral infarction. cerebral amyloid angiopathy is unrelated to generalized amyloidosis. amyloidogenic peptides in this condition are nearly always the same ones found in alzheimer disease. (from kumar: robbins and cotran: pathologic basis of disease, 7th ed., 2005)

  • Cerebral Amyloid Angiopathy, Familial

    a familial disorder marked by amyloid deposits in the walls of small and medium sized blood vessels of cerebral cortex and meninges.

  • Cerebral Amyloid Angiopathy

    a disorder characterized by the deposition of amyloid in the wall of the vessels in the brain.

  • Cerebral Amyloid Angiopathy, APP-Related|HCHWAD|Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch Type

    an autosomal dominant form of cerebral amyloid angiopathy caused by mutation(s) in the app gene, encoding amyloid-beta a4 protein. the deposition of amyloid in cerebral blood vessels wall may lead to degenerative vascular changes that may result in cerebral hemorrhage. mutation(s) in the app gene may also cause autosomal dominant alzheimer disease 1.

Patient EducationClinical

Amyloidosis

Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert I68.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
437.8 Cerebrovasc disease NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About I68.0Overview

Is I68.0 (Cerebrovascular disorders in diseases classified elsewhere) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report cerebral amyloid angiopathy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can I68.0 be a principal diagnosis?

No. This is a manifestation code: cerebral amyloid angiopathy describes the manifestation of an underlying disease rather than the disease itself, so the underlying condition is sequenced first.

What is the ICD-9 equivalent of I68.0?

Under the General Equivalence Mappings, cerebral amyloid angiopathy converts to ICD-9-CM 437.8 (cerebrovasc disease NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.