2027 ICD-10-CM Diagnosis Code I68.0Cerebral amyloid angiopathy

ICD-10-CM Codes›I00–I99›I60-I69›I68

ICD-10-CM I68.0
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

I68.0 is a billable ICD-10-CM diagnosis code for cerebral amyloid angiopathy. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 70 through 72. The code is a manifestation code that cannot be reported as the principal diagnosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other and ill-defined cerebrovascular disease.

Code Identity

ICD-10-CM Code
I68.0
Billable Status
Yes — Valid for Submission
Code Describes
Cerebral amyloid angiopathy
Short Description
Cerebral amyloid angiopathy
Same as the full description in the CMS dataset.
Parent Code
I68
Cerebrovascular disorders in diseases classified elsewhere

Code Classification

ChapterI00–I99Diseases of the circulatory system
SectionI60-I69Cerebrovascular diseases
CategoryI68Cerebrovascular disorders in diseases classified elsewhere
This CodeI68.0Cerebral amyloid angiopathy

Code EditsBilling

Medicare Code Editor checks that affect claim validity for I68.0.

Manifestation diagnoses
Manifestation codes describe the manifestation of an underlying disease, not the disease itself, and therefore should not be used as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Cerebral amyloid angiopathy
  • Cerebral amyloid angiopathy associated with systemic amyloidosis
  • Cerebral non-neuropathic heredofamilial amyloidosis angiopathy
  • Cerebral secondary systemic amyloid angiopathy
  • Familial non-neuropathic amyloidosis
  • Hereditary cerebral hemorrhage with amyloidosis
  • Hereditary cerebrovascular amyloidosis
  • Localized hereditary amyloidosis
  • Secondary systemic amyloidosis

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to I68.0: its own notes plus those printed at block I60-I69 and Chapter 9. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block I60-I69 Cerebrovascular diseases applies to 410 codes
  • traumatic intracranial hemorrhage (S06.-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 9 (I00-I99) Diseases of the circulatory system applies to 1,433 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
  • systemic connective tissue disorders (M30-M36)
  • transient cerebral ischemic attacks and related syndromes (G45.-)

Code First

The underlying condition named in the note is sequenced before this code.

  • underlying amyloidosis (E85.-)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block I60-I69 Cerebrovascular diseases applies to 410 codes
  • code to identify presence of:
  • alcohol abuse and dependence (F10.-)
  • exposure to environmental tobacco smoke (Z77.22)
  • history of tobacco dependence (Z87.891)
  • hypertension (I10-I1A)
  • occupational exposure to environmental tobacco smoke (Z57.31)
  • tobacco dependence (F17.-)
  • tobacco use (Z72.0)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR CIR024
Other and ill-defined cerebrovascular disease
Default principal diagnosis: inpatient No · outpatient No

Clinical InformationClinical

  • Cerebral Amyloid Angiopathy

    a heterogeneous group of sporadic or familial disorders characterized by amyloid deposits in the walls of small and medium sized blood vessels of cerebral cortex and meninges. clinical features include multiple, small lobar cerebral hemorrhage; cerebral ischemia (brain ischemia); and cerebral infarction. cerebral amyloid angiopathy is unrelated to generalized amyloidosis. amyloidogenic peptides in this condition are nearly always the same ones found in alzheimer disease. (from kumar: robbins and cotran: pathologic basis of disease, 7th ed., 2005)

Patient EducationClinical

Amyloidosis

Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert I68.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
437.8 Cerebrovasc disease NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About I68.0Overview

What is the ICD-10 code for cerebral amyloid angiopathy?

The ICD-10-CM code for cerebral amyloid angiopathy is I68.0 (sometimes written as I680). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is I68.0 (Cerebrovascular disorders in diseases classified elsewhere) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report cerebral amyloid angiopathy on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does I68.0 group to?

On inpatient claims, cerebral amyloid angiopathy maps to MS-DRG 72, 70, 71, with relative weights from 0.7344 to 1.6089 depending on complications. Higher weights mean higher Medicare reimbursement.

Can I68.0 be a principal diagnosis?

No. This is a manifestation code: cerebral amyloid angiopathy describes the manifestation of an underlying disease rather than the disease itself, so the underlying condition is sequenced first.

Can I68.0 be reported with a code from S06?

Not as a rule. The Excludes1 note at block I60-I69, which applies to I68.0, lists "traumatic intracranial hemorrhage (S06.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).