2026 ICD-10-CM Diagnosis Code G72.9Myopathy, unspecified

AHRQ’s CCSR groups this code into broader clinical categories.

• 3-Methylglutaconic Aciduria Type 5|3-Methylglutaconic Aciduria Type V|DCMA|Dilated Cardiomyopathy with Ataxia|MGCA5

  an autosomal recessive subtype of 3-methylglutaconic aciduria caused by mutation(s) in the dnajc19 gene, encoding mitochondrial import inner membrane translocase subunit tim14.

• ACTA1 wt Allele|ACTA|ASMA|Actin Alpha 1, Skeletal Muscle wt Allele|Actin, Alpha, Skeletal Muscle 1 Gene|CFTD|CFTD1|CFTDM|MPFD|NEM1|NEM2|NEM3|Nemaline Myopathy Type 3 Gene|SHPM

  human acta1 wild-type allele is located in the vicinity of 1q42.13 and is approximately 4 kb in length. this allele, which encodes actin, alpha skeletal muscle protein, is involved in sarcomere formation and contractile activity. mutation of the gene is associated with scapulohumeroperoneal myopathy, nemaline myopathy 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion 1.

• Alcoholic Cardiomyopathy|Alcoholic cardiomyopathy

  a dilated cardiomyopathy which is associated with consumption of large amounts of alcohol over a period of years.

• Arrhythmia-Induced Cardiomyopathy|AiCM

  a reversible cardiomyopathy presumed to result from the presence of arrhythmias, including the tachycardia-induced cardiomyopathy (t-cm), atrial fibrillation-induced cardiomyopathy (af-cm), and premature ventricular contraction-induced cardiomyopathy (pvc-cm).

• Arrhythmogenic Right Ventricular Dysplasia|ARVD|Arrhythmogenic RVD|Arrhythmogenic Right Ventricular Cardiomyopathy|Right Ventricular Dysplasia

  a rare genetic disorder characterized by cardiomyopathy affecting the right ventricle. the heart tissue is replaced by fibrous and adipose tissues. it is characterized by ventricular arrhythmia and right ventricular dysfunction. it is a cause of sudden death.

• Bethlem Myopathy 1|BTHLM1

  a usually autosomal dominant inherited movement disorder caused by mutations in the col6a1, col6a2, and col6a3 genes. it is characterized by progressive muscle weakness and joint stiffness in the fingers, wrists, elbows, and ankles.

• Cardiomyopathy in Chagas' Disease|Cardiovascular Trypanosomiasis|Chronic Chagas' Disease Cardiomyopathy

  a dilated cardiomyopathy caused by the protozoan trypanosoma cruzi. patients may present with heart block, congestive heart failure, or anginal symptoms.

• Cardiomyopathy|CARDIOMYOPATHY|Cardiomyopathy, NOS

  a disease of the heart muscle or myocardium proper. cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.

• Central Core Disease|Central Core Myopathy

  an autosomal dominant congenital disorder affecting the skeletal muscles. microscopically, it is characterized by disorganized areas, which are called cores, seen usually in the center of the muscle fibers. clinically it presents as mild to severe muscle weakness. it may be associated with skeletal abnormalities including scoliosis, joint deformities, and hip dislocation.

• Centronuclear Myopathy 1|CNM1

  a myopathy inherited in an autosomal dominant or recessive pattern, caused by mutations in the dnm2, bin1, and ttn genes. microscopically there is central displacement of the nucleus in muscle cells. it is characterized by muscle weakness and atrophy in the skeletal muscles.

• Conduction System Hamartoma|Arachnocytosis of the Myocardium|CSH|Congenital Cardiomyopathy|Histiocytoid Cardiomyopathy|Infantile Xanthomatous Cardiomyopathy|Isolated Cardiac Lipidosis|Myocardial Hamartoma|Oncocytic Cardiomyopathy|Purkinje Cell Hamartoma

  a hamartomatous lesion of the sinoatrial node, atrioventricular node, and purkinje fibers of the cardiac conducting system. it occurs predominantly in the first two years of life. most patients present with arrhythmias and electrical disturbances. it is characterized by the presence of multifocal, poorly defined islands of large polygonal cells with a granular eosinophilic cytoplasm, a small round to oval-shaped nucleus, and occasional nucleoli. the cytoplasmic appearance is due to extensive accumulation of mitochondria. if left untreated, this condition is usually fatal. however, the outcome has improved over the past two decades due to developments in surgical intervention, electrophysiological mapping, and ablation of the arrhythmogenic foci, with a survival rate of approximately 80%. (who 2015)

• Congenital Fiber-Type Disproportion|Congenital Fiber-Type Disproportion Myopathy

  a rare genetic disorder caused by mutations in the tpm3, acta1, ryr1 and sepn1 genes. it is inherited in an autosomal dominant or recessive pattern and rarely in an x-linked pattern. it manifests with myopathy throughout the body, particularly in the muscles of the shoulders, upper arms, hips, and thighs. affected individuals may have contractures, lordosis, or scoliosis. in a minority of cases mild to severe breathing problems may occur.

• Congenital Structural Myopathy|Centronuclear Myopathy

  a group of rare genetic muscle disorders characterized by hypotonia, muscle weakness, and delayed development of motor skills.

• Critical Illness Myopathy|Critical illness myopathy

  acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. it is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation.

• Critical Illness Polyneuromyopathy|Critical illness polyneuropathy/myopathy

  polyneuropathy and myopathy arising in intensive care unit patients.

• Dermatopolymyositis, Unspecified with Myopathy|Dermatopolymyositis, unspecified with myopathy

  evidence of dermatopolymyositis, unspecified with myopathy.

• Dermatopolymyositis, Unspecified without Myopathy|Dermatopolymyositis, unspecified without myopathy

  evidence of dermatopolymyositis, unspecified without myopathy.

• Dilated Cardiomyopathy|Congestive Cardiomyopathy

  cardiomyopathy which is characterized by dilation and contractile dysfunction of the left and right ventricles. it may be idiopathic, or it may result from a myocardial infarction, myocardial infection, or alcohol abuse. it is a cause of congestive heart failure.

• Dilated Cardiomyopathy-1A|CMD1A

  an autosomal dominant subtype of dilated cardiomyopathy caused by mutation(s) in the lmna gene, encoding lamin-a and lamin c.

• Dilated Cardiomyopathy-1C|CMD1C

  an autosomal dominant subtype of dilated cardiomyopathy caused by mutation(s) in the ldb3 gene, encoding lim domain-binding protein 3.

• Dilated Cardiomyopathy-1D

  an autosomal dominant subtype of dilated cardiomyopathy caused by mutation(s) in the tnnt2 gene, encoding troponin t, cardiac muscle.

• Dilated Cardiomyopathy-1DD|CMD1DD

  an autosomal dominant subtype of dilated cardiomyopathy caused by mutation(s) in the rbm20 gene, encoding rna-binding protein 20.

• Dilated Cardiomyopathy-1G

  a subtype of dilated cardiomyopathy caused by mutation(s) in the ttn gene, encoding titin.

• Dilated Cardiomyopathy-1HH|CMD1HH

  an autosomal dominant subtype of dilated cardiomyopathy caused by mutation(s) in the bag3 gene, encoding bag family molecular chaperone regulator 3.

• Dilated Cardiomyopathy-1P|CMD1P

  an autosomal dominant subtype of dilated cardiomyopathy caused by mutation(s) in the pln gene, encoding cardiac phospholamban.

• Dilated Cardiomyopathy-1W|CMD1W

  an genetic condition that is a subtype of dilated cardiomyopathy caused by mutation(s) in the vcl gene, encoding vinculin.

• Dilated Cardiomyopathy-2C|CMD2C

  an autosomal recessive subtype of dilated cardiomyopathy caused by mutation(s) in the ppcs gene, encoding phosphopantothenate--cysteine ligase.

• Dilated Cardiomyopathy-Hypergonadotropic Hypogonadism Syndrome|DCM-HH|Malouf Syndrome|Najjar Syndrome

  an autosomal dominant condition caused by mutation(s) in the lmna gene, encoding prelamin-a/c. it is characterized by dilated cardiomyopathy and hypergonadotropic hypogonadism.

• Distal Muscular Dystrophy|Distal Myopathy

  a group of genetic degenerative muscle disorders affecting the muscles of the lower arms, hands, lower legs, and feet.

• Dystrophia Myotonica 2|DM2|Myotonic Dystrophy 2|PROMM|Proximal Myotonic Myopathy|Ricker Syndrome

  a rare autosomal dominant disorder caused by mutations in the cnbp gene. it is characterized by muscle pain, fatigue, and weakness of the proximal muscles of the lower extremities.

• Familial Arrhythmogenic Right Ventricular Dysplasia 5|ARVC5|ARVD5|Arrhythmogenic Right Ventricular Cardiomyopathy 5

  an autosomal dominant arrhythmogenic cardiomyopathy caused by mutations(s) in the tmem43 gene on chromosome 3p25, encoding transmembrane protein 43. it is characterized by ventricular ectopy, left ventricular dilation, heart failure, and early death.

• Familial Hypertrophic Cardiomyopathy Type 1|Asymmetric Septal Hypertrophy|CMH1|Hereditary Ventricular Hypertrophy|IHSS|Idiopathic Hypertrophic Subaortic Stenosis

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the cav3 gene, myh7 gene, or mylk2 gene encoding caveolin-3, myosin heavy chain 7, and myosin light chain kinase 2, skeletal/cardiac muscle respectively.

• Familial Hypertrophic Cardiomyopathy Type 11|CMH11

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the actc1 gene, encoding actin, alpha cardiac muscle 1.

• Familial Hypertrophic Cardiomyopathy Type 14|CMH14

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the myh6 gene, encoding myosin-6.

• Familial Hypertrophic Cardiomyopathy Type 17|CMH17

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the jph2 gene, encoding junctophilin-2.

• Familial Hypertrophic Cardiomyopathy Type 2|CMH2

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the tnnt2 gene, encoding troponin t, cardiac muscle.

• Familial Hypertrophic Cardiomyopathy Type 26|CMH26

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the flnc gene, encoding filamin-c.

• Familial Hypertrophic Cardiomyopathy Type 27|CMH27

  an autosomal recessive subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the alpk3 gene, encoding alpha-protein kinase 3.

• Familial Hypertrophic Cardiomyopathy Type 3|CMH3

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the tpm1 gene, encoding tropomyosin alpha-1 chain.

• Familial Hypertrophic Cardiomyopathy Type 4|CMH4

  an autosomal dominant condition caused by mutation(s) in the mybpc3 gene, encoding mybpc3 protein. it is characterized by severe neonatal hypertrophic cardiomyopathy.

• Familial Hypertrophic Cardiomyopathy Type 6|CMH6

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the prkag2 gene, encoding 5'-amp-activated protein kinase subunit gamma-2.

• Familial Hypertrophic Cardiomyopathy Type 7|CMH7

  an autosomal dominant subtype of familial hypertrophic cardiomyopathy caused by mutation(s) in the tnni3 gene, encoding troponin i, cardiac muscle.

• Familial Hypertrophic Cardiomyopathy|Hypertrophic Familial Cardiomyopathy

  hypertrophic cardiomyopathy caused by mutations in the genes encoding components of the sarcomere, in the absence of predisposing conditions.

• Familial Restrictive Cardiomyopathy 5|RCM5

  an autosomal dominant condition caused by mutation(s) in the flnc gene, encoding filamin-c. it is characterized by restrictive cardiomyopathy in the context of normal contractility, left ventricular wall thickness and systolic function.

• Family History of Cardiomyopathy|Cardiomyopathy

  a history of a first-degree relative that was diagnosed with cardiomyopathy.

• Grade 1 Restrictive Cardiomyopathy, CTCAE|Grade 1 Restrictive cardiomyopathy|Grade 1 Restrictive cardiomyopathy

  imaging findings only

• Grade 2 Restrictive Cardiomyopathy, CTCAE|Grade 2 Restrictive cardiomyopathy|Grade 2 Restrictive cardiomyopathy

  symptomatic without signs of heart failure

• Grade 3 Restrictive Cardiomyopathy, CTCAE|Grade 3 Restrictive cardiomyopathy|Grade 3 Restrictive cardiomyopathy

  symptomatic heart failure or other cardiac symptoms, responsive to intervention; new onset of symptoms

• Grade 4 Restrictive Cardiomyopathy, CTCAE|Grade 4 Restrictive cardiomyopathy|Grade 4 Restrictive cardiomyopathy

  refractory heart failure or other poorly controlled cardiac symptoms

• Grade 5 Restrictive Cardiomyopathy, CTCAE|Grade 5 Restrictive cardiomyopathy|Grade 5 Restrictive cardiomyopathy

  death

• Hereditary Transthyretin Amyloid Cardiomyopathy|hATTR-CM

  transthyretin amyloid cardiomyopathy caused by mutation(s) in the ttr gene, encoding transthyretin.

• Hypertrophic Cardiomyopathy

  a condition in which the myocardium is hypertrophied without an obvious cause. the hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

• Idiopathic Cardiomyopathy

  a disease of the heart muscle or myocardium proper whose cause is unknown.

• Idiopathic Inflammatory Myopathy|IIM|IIM|Idiopathic Inflammatory Myopathies|Idiopathic Inflammatory Myopathies

  an umbrella term for diseases which have chronic muscle inflammation and weakness of unknown etiology. the types of idiopathic inflammatory myopathy are further defined by either clinicopathologic criteria or by the presence of certain autoantibodies.

• Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 1|IBMPFD1

  a rare autosomal dominant inherited disorder caused by mutations in the vcp gene. it can affect the muscles, bones, and brain. patients may develop myopathy that initially involves the muscles of the hips and shoulders and as the disorder progresses it may affect the cardiac and respiratory muscles, leading to life-threatening cardiac and pulmonary failure. approximately half of the adults develop paget disease of bone, and approximately one-third develop frontotemporal dementia.

• Intermediate Epidermolysis Bullosa Simplex with Cardiomyopathy

  an autosomal dominant condition caused by mutation(s) in the klhl24 gene, encoding kelch-like protein 24. it is characterized by epidermolysis bullosa and dilated cardiomyopathy.

• Ischemic Cardiomyopathy Associated with Post-Acute Sequelae of SARS-CoV-2 Infection|PASC Ischemic Cardiomyopathy|PASC ischemic cardiomyopathy|Post-Acute Sequelae of COVID-19 Ischemic Cardiomyopathy

  reduced left ventricular function with less than 50% ejection fraction in a patient with history of suspected or confirmed myocardial ischemia or acute coronary syndrome (acs) that started during probable or confirmed acute covid-19 and persisted beyond four weeks after the initial diagnosis of covid-19.

• Juvenile Dermatomyositis Sine Myositis|Juvenile Amyopathic Dermatomyositis|Juvenile Amyopathic Dermatomyositis|Juvenile Dermatomyositis sine Myositis|Juvenile dermatomyositis without myopathy

  a rare form of juvenile dermatomyositis that manifests with characteristic cutaneous findings for at least six months in the absence of any detectable muscle involvement.

• Juvenile Dermatomyositis with Myopathy|Juvenile dermatomyositis with myopathy

  evidence of juvenile dermatomyositis with myopathy.

• Left Ventricular Non-Compaction Syndrome|LV Non-Compaction Syndrome|LVNC|Left Ventricular Non-Compaction Cardiomyopathy

  an uncommon congenital abnormality where the left ventricular myocardium fails to compact during embryonic development, leading to cardiomyopathy with a variable degree of ventricular dysfunction. there is genetic heterogeneity and phenotypic variability. characteristically, there are typically deep trabeculations in the noncompacted area, with varying proportions of the lv myocardium compacted. lv noncompaction is associated with rhythm abnormalities including wolff-parkinson-white syndrome, conduction defects, and ventricular tachyarrhythmias.

• LMNA wt Allele|CDCD1|CDDC|CMD1A|CMT2B1|Cardiomyopathy, Dilated 1A (Autosomal Dominant)|EMD2|FPL|FPLD|FPLD2|HGPS|IDC|LDP1|LFP|LGMD1B|LMN1|LMNC|LMNL1|Lamin A/C wt Allele|Lamin A/C-Like 1 Gene|Lamin-A/C Gene|Limb Girdle Muscular Dystrophy 1B (Autosomal Dominant) Gene|MADA|Mandibuloacral Dysplasia Type A Gene|PRO1|Progeria 1 (Hutchinson-Gilford Type) Gene

  human lmna wild-type allele is located within 1q22 and is approximately 25 kb in length. this allele, which encodes prelamin-a/c protein, plays a role in nuclear stability and chromatin structure. mutations in the lmna gene are associated with charcot-marie-tooth disease, type 2b1, hutchinson-gilford progeria syndrome, emery-dreifuss muscular dystrophy, malouf syndrome, autosomal dominant familial partial lipodystrophy type 2, lethal restrictive dermopathy, autosomal dominant limb girdle muscular dystrophy 1b and autosomal dominant dilated cardiomyopathy 1a..

• MELAS Syndrome|MELAS|Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke

  a rare progressive neurodegenerative disorder characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.

• Metabolic Myopathy

  a group of rare inherited disorders characterized by a deficiency of enzymes that are involved in metabolic pathways that affect muscles. the disorders are characterized by muscle dysfunction.

• Minicore Myopathy with External Ophthalmoplegia

  an autosomal recessive condition caused by mutation(s) in the ryr1 gene, encoding ryanodine receptor 1. it may be characterized clinically by neonatal hypotonia, delayed motor development, and generalized muscle weakness, and amyotrophy. pathologically, the absence of mitochondria and focal disorganization of the sarcomere appear as "minicores" on atpase staining as a result of focal defects in oxidative activity.

• Mitochondrial Myopathy

  myopathy caused by mitochondrial abnormalities.

• Muscular Dystrophies and Storage Diseases Leading to Cardiomyopathy|Other Muscular Dystrophies and Storage Diseases That Lead to Cardiomyopathies

  a muscular dystrophy or storage disease that causes cardiomyopathy.

• MYH6 wt Allele|ASD3|Alpha-MHC Gene|CMD1EE|CMH14|MYH, Cardiac Gene|MYHC|MYHCA|Myosin Heavy Chain 6 wt Allele|Myosin, Cardiac Heavy Chain Gene|Myosin, Heavy Chain 6, Cardiac Muscle, Alpha Gene|Myosin, Heavy Polypeptide 6, Cardiac Muscle, Alpha (Cardiomyopathy, Hypertrophic 1) Gene|Myosin, Heavy Polypeptide 6, Cardiac Muscle, Alpha Gene|SSS3

  human myh6 wild-type allele is located in the vicinity of 14q11.2 and is approximately 26 kb in length. this allele, which encodes myosin-6 protein, plays a role in atrial muscle cell contraction. mutation of the gene is associated with atrial septal defect 3, sick sinus syndrome 3, dilated cardiomyopathy 1ee and hypertrophic cardiomyopathy 14.

• Myofibrillar Myopathy

  an inherited or sporadic disorder affecting the skeletal muscles.

• Myomegalin|Cardiomyopathy-Associated Protein 2|Myomegalin-Like Protein|PDE4DIP|Phosphodiesterase 4D-Interacting Protein

  myomegalin (2346 aa, ~265 kda) is encoded by the human pde4dip gene. this protein plays a role in the localization of phosphodiesterase 4d.

• Myopathy

  a non-neoplastic disorder that affects the muscles. representative examples include muscular dystrophy, metabolic myopathies, muscular atrophies, and dermatomyositis.

• Myopathy due to Myoadenylate Deaminase Deficiency|MMDD

  an autosomal recessive condition caused by mutation(s) in the ampd1 gene, encoding amp deaminase 1. the condition is characterized by exercise-induced muscle pain and/or fatigue, which may be associated with rhabdomyolysis and/or increased concentrations of creatinine kinase.

• Myopathy Secondary to Fatty Acid Oxidation Disorder|Fatty acid oxidation disorder

  a myopathy that was caused by a primary disorder of fatty acid oxidation.

• Myopathy Secondary to Glycogen Storage Disorder|Glycogen storage disorder

  a myopathy that was caused by a primary disorder of glycogen storage.

• Nemaline Myopathy 2|NEM2

  an autosomal recessive inherited myopathy caused by mutations in the neb gene. it is characterized by generalized hypotonia and skeletal muscle weakness.

• Nemaline Myopathy 3|NEM3

  an inherited myopathy caused by mutations in the acta1 gene, encoding actin, alpha skeletal muscle. the phenotype is highly variable, and as such attempts at classification by clinical features is not optimal. generally, affected individuals have generalized muscle weakness, typically involving proximal muscles, the face, bulbar and respiratory muscles.

• Nemaline Myopathy 4|NEM4

  an autosomal dominant myopathy caused by mutation(s) in the tpm2 gene, encoding tropomyosin beta chain. classification of nemaline myopathies by clinical features is not optimal, as the phenotypes are highly variable.

• Nemaline Myopathy 8|NEM8

  an autosomal recessive myopathy caused by mutations in the klhl40 gene, encoding kelch-like protein 40. the phenotype is highly variable, and as such attempts at classification by clinical features is not optimal. generally, affected individuals have generalized muscle weakness, and typically involves proximal muscles, the face, bulbar and respiratory muscles.

• No History of Myopathy|No

  an indication that the patient does not have a history of myopathy.

• Nonaka Myopathy|GNE Myopathy

  an autosomal recessive condition caused by mutation(s) in the gne gene, encoding bifunctional udp-n-acetylglucosamine 2-epimerase/n-acetylmannosamine kinase. it is characterized by distal muscle weakness and atrophy, especially the tibialis anterior, and sparing of the quadriceps.

• Non-Ischemic Cardiomyopathy Associated with Post-Acute Sequelae of SARS-CoV-2 Infection|PASC Non-Ischemic Cardiomyopathy|PASC nonischemic cardiomyopathy|Post-Acute Sequelae of COVID-19 Non-Ischemic Cardiomyopathy

  reduced left ventricular function with less than 50% ejection fraction but without evidence of myocardial ischemia that started during probable or confirmed acute covid-19 and persisted beyond four weeks after the initial diagnosis of covid-19.

• Oculopharyngodistal Myopathy 2|OPDM2

  an autosomal dominant condition caused by mutation(s) in the gipc1 gene, encoding pdz domain-containing protein gipc1. it is characterized by distal muscle weakness and ophthalmoplegia, with a slowly progressive course.

• Other Dermatomyositis with Myopathy|Other dermatomyositis with myopathy

  evidence of other dermatomyositis with myopathy not specified elsewhere.

• Other Dermatomyositis without Myopathy|Other dermatomyositis without myopathy

  evidence of other dermatomyositis without myopathy not specified elsewhere.

• Paraneoplastic Neuromyopathy and Neuropathy|Paraneoplastic neuromyopathy and neuropathy

  evidence of paraneoplastic neuromyopathy and neuropathy.

• PDE4DIP wt Allele|CMYA2|Cardiomyopathy Associated 2 Gene|DKFZp781J054|KIAA0454|KIAA0477|MGC75440|MMGL|Myomegalin, Rat, Homolog of Gene|Phosphodiesterase 4D Interacting Protein wt Allele

  human pde4dip wild-type allele is located in the vicinity of 1q12 and is approximately 240 kb in length. this allele, which encodes myomegalin protein, is involved in the localization of phosphodiesterase activity. a chromosomal translocation t(1;5)(q23;q33) of this gene and the pdgfrb gene is associated with myeloproliferative disorder associated with eosinophilia.

• Peripartum Cardiomyopathy|PPCM

  a condition presenting toward the end of pregnancy or in the months following delivery characterized by left ventricular dysfunction. the nhlbi introduced the metric of left ventricular ejection fraction of less than 45 percent in 1999. microrna-146a has been cited as a potential biomarker for ppcm.

• Polymyositis with Myopathy|Polymyositis with myopathy

  evidence of polymyositis with myopathy.

• Porcine Myopathy|Myopathy, Porcine|PORCINE MYOPATHY

  a spontaneous muscular disease in minipigs, characterized by changes in skeletal myofibers, including both acute (dominated by necrosis, hemorrhage, edema, and mixed inflammatory cell infiltrates) and more chronic lesions (characterized by basophilic regenerating myofibers, mineralization, and occasionally fibrosis). (inhand)

• Restrictive Cardiomyopathy, CTCAE|Restrictive Cardiomyopathy|Restrictive cardiomyopathy|Restrictive cardiomyopathy

  a disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility.

• Restrictive Cardiomyopathy|Restrictive cardiomyopathy

  a type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Left Ankle and Foot|Rheumatoid myopathy with rheumatoid arthritis of left ankle and foot

  evidence of rheumatoid myopathy with rheumatoid arthritis of left ankle and foot.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Left Elbow|Rheumatoid myopathy with rheumatoid arthritis of left elbow

  evidence of rheumatoid myopathy with rheumatoid arthritis of left elbow.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Left Hand|Rheumatoid myopathy with rheumatoid arthritis of left hand

  evidence of rheumatoid myopathy with rheumatoid arthritis of left hand.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Left Hip|Rheumatoid myopathy with rheumatoid arthritis of left hip

  evidence of rheumatoid myopathy with rheumatoid arthritis of left hip.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Left Knee|Rheumatoid myopathy with rheumatoid arthritis of left knee

  evidence of rheumatoid myopathy with rheumatoid arthritis of left knee.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Left Shoulder|Rheumatoid myopathy with rheumatoid arthritis of left shoulder

  evidence of rheumatoid myopathy with rheumatoid arthritis of left shoulder.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Left Wrist|Rheumatoid myopathy with rheumatoid arthritis of left wrist

  evidence of rheumatoid myopathy with rheumatoid arthritis of left wrist.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Multiple Sites|Rheumatoid myopathy with rheumatoid arthritis of multiple sites

  evidence of rheumatoid myopathy with rheumatoid arthritis of multiple sites.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Right Ankle and Foot|Rheumatoid myopathy with rheumatoid arthritis of right ankle and foot

  evidence of rheumatoid myopathy with rheumatoid arthritis of right ankle and foot.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Right Elbow|Rheumatoid myopathy with rheumatoid arthritis of right elbow

  evidence of rheumatoid myopathy with rheumatoid arthritis of right elbow.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Right Hand|Rheumatoid myopathy with rheumatoid arthritis of right hand

  evidence of rheumatoid myopathy with rheumatoid arthritis of right hand.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Right Hip|Rheumatoid myopathy with rheumatoid arthritis of right hip

  evidence of rheumatoid myopathy with rheumatoid arthritis of right hip.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Right Knee|Rheumatoid myopathy with rheumatoid arthritis of right knee

  evidence of rheumatoid myopathy with rheumatoid arthritis of right knee.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Right Shoulder|Rheumatoid myopathy with rheumatoid arthritis of right shoulder

  evidence of rheumatoid myopathy with rheumatoid arthritis of right shoulder.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Right Wrist|Rheumatoid myopathy with rheumatoid arthritis of right wrist

  evidence of rheumatoid myopathy with rheumatoid arthritis of right wrist.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Ankle and Foot|Rheumatoid myopathy with rheumatoid arthritis of unspecified ankle and foot

  evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified ankle and foot.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Elbow|Rheumatoid myopathy with rheumatoid arthritis of unspecified elbow

  evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified elbow.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Hand|Rheumatoid myopathy with rheumatoid arthritis of unspecified hand

  evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified hand.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Hip|Rheumatoid myopathy with rheumatoid arthritis of unspecified hip

  evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified hip.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Knee|Rheumatoid myopathy with rheumatoid arthritis of unspecified knee

  evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified knee.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Shoulder|Rheumatoid myopathy with rheumatoid arthritis of unspecified shoulder

  evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified shoulder.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Site|Rheumatoid myopathy with rheumatoid arthritis of unspecified site

  evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified site.

• Rheumatoid Myopathy with Rheumatoid Arthritis of Unspecified Wrist|Rheumatoid myopathy with rheumatoid arthritis of unspecified wrist

  evidence of rheumatoid myopathy with rheumatoid arthritis of unspecified wrist.

• Rodent Progressive Cardiomyopathy|RODENT PROGRESSIVE CARDIOMYOPATHY

  a spontaneous, age-related cardiac disease of rats and mice, characterized by myocardial changes presenting a continuum that begins as focal to multifocal individual cardiomyocyte necrosis attended by a few inflammatory cells progressing at different rates in different animals to include multifocal mononuclear cell inflammation and even fibrosis for larger lesions. (inhand)

• Sicca Syndrome with Myopathy|Sicca syndrome with myopathy

  evidence of sicca syndrome with myopathy.

• Steroid Myopathy

  a non-neoplastic disorder affecting the skeletal muscles. it is caused by damage to muscle fibers either by excessive intake of corticosteroids (steroid treatment) or high levels of endogenous corticosteroids due to hormonal abnormalities. patients usually present with weakness mainly in the proximal muscles of the upper and lower extremities and the neck flexors.

• Systemic Sclerosis with Myopathy|Systemic sclerosis with myopathy

  evidence of systemic sclerosis with myopathy.

• TAFAZZIN wt Allele|BTHS|Barth Syndrome Gene|CMD3A|Cardiomyopathy, Dilated 3A (X-Linked) Gene|EFE|EFE2|Endocardial Fibroelastosis 2 Gene|G4.5|LVNCX|TAZ|TAZ1|Tafazzin, Phospholipid-Lysophospholipid Transacylase wt Allele|Taz1

  human tafazzin wild-type allele is located in the vicinity of xq28 and is approximately 10 kb in length. this allele, which encodes tafazzin protein, plays a role in phospholipid metabolism, including cardiolipin remodeling. mutations in the gene are associated with barth syndrome, dilated cardiomyopathy (dcm), hypertrophic dcm, endocardial fibroelastosis and left ventricular noncompaction.

• Takotsubo Cardiomyopathy|Broken-heart Syndrome|TTS|Tako-Tsubo Cardiomyopathy|Takotsubo Syndrome|Takotsubo syndrome

  a rare disorder characterized by transient left ventricular wall systolic dysfunction, resulting in apical ballooning appearance, chest pain, and st segment elevation.

• TNNT2 wt Allele|CMH2|CMPD2|Cardiomyopathy, Hypertrophic 2 Gene|LVNC6|RCM3|TnTC|Troponin T Type 2 (Cardiac) wt Allele|cTnT

  human tnnt2 wild-type allele is located in the vicinity of 1q32 and is approximately 19 kb in length. this allele, which encodes troponin t, cardiac muscle, is involved in muscle contraction.

• TPM1 wt Allele|C15orf13|CMD1Y|CMH3|Cardiomyopathy, Hypertrophic 3 Gene|Chromosome 15 Open Reading Frame 13 Gene|HTM-alpha|LVNC9|TMSA|Tropomyosin 1 (Alpha) wt Allele

  human tpm1 wild-type allele is located in the vicinity of 15q22.1 and is approximately 29 kb in length. this allele, which encodes tropomyosin alpha-1 chain protein, is involved in the regulation of muscle contraction. mutation of the gene is associated with left ventricular non-compaction 9 and cardiomyopathy types familial hypertrophic 3 and dilated 1y.

• TPM2 wt Allele|AMCD1|Arthrogryposis Multiplex Congenital, Distal, Type 1 Gene|DA1|DA2B|HEL-S-273|NEM4|Nemaline Myopathy Type 4 Gene|TMSB|Tropomyosin 2 (Beta) wt Allele|Tropomyosin, Skeletal Muscle Beta Gene

  human tpm2 wild-type allele is located in the vicinity of 9p13 and is approximately 9 kb in length. this allele, which encodes tropomyosin beta chain protein, is involved in muscle contraction. mutation of the gene is associated with nemaline myopathy type 4, cap myopathy type 2 and distal arthrogryposis types 1a and 2b.

• Transthyretin Amyloid Cardiomyopathy|ATTR-CM

  cardiomyopathy resulting from the deposition of misfolded transthyretin. the condition can be classified by the presence (hereditary transthyretin amyloid) or absence (wild-type transthyretin amyloid) of mutation(s) in the ttr gene, encoding transthyretin.

• TTN wt Allele|CMD1G|CMH9|CMPD4|Cardiomyopathy, Dilated 1G (Autosomal Dominant) Gene|DKFZp451N061|EOMFC|FLJ26020|FLJ26409|FLJ32040|FLJ34413|FLJ39564|FLJ43066|HMERF|LGMD2J|MYLK5|TMD|Titin wt Allele

  human ttn wild-type allele is located in the vicinity of 2q31 and is approximately 305 kb in length. this allele, which encodes titin protein, is involved in both muscle filament structure and protein phosphorylation. mutation of the gene is associated with hereditary myopathy with early respiratory failure, familial hypertrophic cardiomyopathy type 9, cardiomyopathy dilated type 1g, tardive tibial muscular dystrophy, limb-girdle muscular dystrophy type 2j and early-onset myopathy with fatal cardiomyopathy.

• Unknown History of Myopathy|Unknown

  an indication that it is unknown whether the patient has a history of myopathy.

• X-Linked Centronuclear Myopathy|CNMX|MTM|MTM1|Myotubular Myopathy 1|X-Linked Myotubular Myopathy|XLCNM

  an x-linked recessive inherited disorder caused by mutations in the mtm1 gene. primarily it affects males. female carriers are usually asymptomatic. it is characterized by skeletal muscle weakness and hypotonia. the muscle weakness ranges from mild to severe. newborns with severe x-linked centronuclear myopathy develop respiratory distress which may lead to respiratory failure requiring constant ventilator assistance. patients with mild x-linked centronuclear myopathy usually require ventilator support during the newborn period only.

• Autosomal Dominant Congenital Myopathy-1A|CMYP1A

  an autosomal dominant condition caused by mutation(s) in the ryr1 gene, encoding ryanodine receptor 1. the phenotype is variable, but generally includes weakness in the proximal muscles of the lower limb and individuals are at increased risk for malignant hyperthermia.

• Autosomal Dominant Myosin Storage Congenital Myopathy 7A|CMYP7A

  an autosomal dominant form of congenital myopathy caused by mutation(s) in the myh7 gene, encoding myosin-7.

• Dilated Cardiomyopathy-1II|CMD1II

  an autosomal dominant subtype of dilated cardiomyopathy caused by mutation(s) in the cryab gene, encoding alpha-crystallin b chain.

• Distal Myopathy-5|MPD5

  an autosomal dominant condition caused by mutation(s) in the adss1 gene, encoding adenylosuccinate synthetase isozyme 1. it is characterized by adolescent onset of distal muscular weakness primarily affecting the lower limbs.

• Hereditary Cardiac ATTR Amyloidosis|Familial Cardiac ATTR Amyloidosis|Familial Cardiac Transthyretin Amyloidosis|Hereditary Transthyretin Amyloid Cardiomyopathy|Hereditary Transthyretin Amyloid Cardiomyopathy|Hereditary Transthyretin Amyloid Cardiomyopathy|hATTR-CM

  the accumulation of attr amyloid deposits in the heart due to mutations in the ttr gene.

• Immune-Mediated Necrotizing Myopathy|IMNM|NAM|Necrotizing Autoimmune Myopathy

  a subgrouping of the inflammatory myopathies characterized by severe proximal weakness, elevated creatine kinase levels, and myofiber necrosis. they can be further distinguished by the presence or absence of associated autoantibodies, including anti-3-hydroxy-3-methylglutaryl-coa reductase (hmgcr), anti-signal recognition particle (srp), and antibody negative immune-mediated necrotizing myopathy (imnm).

• KLHL40 wt Allele|KBTBD5|Kelch Like Family Member 40 wt Allele|Kelch Repeat and BTB (POZ) Domain Containing 5 Gene|Kelch-Like 40 (Drosophila) Gene|Kelch-Like 40 Gene|NEM8|Nemaline Myopathy Type 8 Gene|SRYP|SYRP

  human klhl40 wild-type allele is located in the vicinity of 3p22.1 and is approximately 7 kb in length. this allele, which encodes kelch-like protein 40, is involved in targeting proteins for ubiquitination and degradation. mutation of the gene is associated with nemaline myopathy 8.

• LDB3 wt Allele|CMD1C|CMH24|CMPD3|CYPHER|Cardiomyopathy, Dilated 1C (Autosomal Dominant) Gene|Cypher Gene|Cypher, Mouse, Homolog of Gene|KIAA0613|LDB3Z1|LDB3Z4|LIM Domain Binding 3 wt Allele|LIM Domain-Binding 3 Gene|LVNC3|MFM4|ORACLE|Oracle Gene|PDLIM6|PDZ and LIM Domain 6 Gene|ZASP

  human ldb3 wild-type allele is located in the vicinity of 10q23.2 and is approximately 69 kb in length. this allele, which encodes lim domain-binding protein 3, plays a role in maintaining the structural integrity of the z-discs in striated muscle. mutation of the gene is associated with dilated cardiomyopathy 1c, hypertrophic cardiomyopathy 24, left ventricular noncompaction 3 and myofibrillar myopathy 4.

• MTM1 wt Allele|CG2|CNM|CNMX|MTMX|Myotubular Myopathy 1 Gene|Myotubularin 1 wt Allele|XLMTM

  human mtm1 wild-type allele is located in the vicinity of xq28 and is approximately 110 kb in length. this allele, which encodes myotubularin protein, is involved in the dephosphorylation of phospholipids. mutations in the gene are associated with x-linked centronuclear myopathy.

• Myofibrillar Myopathy 1|MFM1

  a subtype of myofibrillar myopathy caused by mutations in the des gene, encoding desmin.

• Myofibrillar Myopathy 2|MFM2

  an autosomal dominant subtype of myofibrillar myopathy caused by mutation(s) in the cryab gene, encoding alpha-crystallin b chain.

• Myofibrillar Myopathy 3|MFM3

  an autosomal dominant subtype of myofibrillar myopathy caused by mutation(s) in the myot gene, encoding myotilin.

• Myofibrillar Myopathy 5|MFM5

  an autosomal dominant subtype of myofibrillar myopathy caused by mutation(s) in the flnc gene, encoding filamin-c.

• NEB wt Allele|AMC6|NEB177D|NEM2|Nebulin wt Allele|Nemaline Myopathy Type 2 Gene

  human neb wild-type allele is located in the vicinity of 2q23.3 and is approximately 249 kb in length. this allele, which encodes nebulin protein, plays a role in muscle cell development and sarcomere maintenance. mutations in the gene are associated with arthrogryposis multiplex congenita 6 and autosomal recessive nemaline myopathy 2.

• TNNT2 wt Allele|CMD1D|CMH2|CMPD2|Cardiomyopathy, Dilated 1D (Autosomal Dominant) Gene|Cardiomyopathy, Hypertrophic 2 Gene|LVNC6|RCM3|TnTC|Troponin T Type 2 (Cardiac) Gene|Troponin T2, Cardiac Type wt Allele|cTnT

  human tnnt2 wild-type allele is located in the vicinity of 1q32.1 and is approximately 19 kb in length. this allele, which encodes troponin t, cardiac muscle, is involved in muscle contraction.

• Visceral Myopathy 1|VSCM1

  an autosomal dominant type of functional intestinal obstruction caused by mutation(s) in the actg2 gene, encoding actin, gamma-enteric smooth muscle.

• X-Linked Dominant Scapuloperoneal Myopathy|SPM

  an x-linked dominant condition caused by mutation(s) in the fhl1 gene, encoding four and a half lim domains protein 1. it is characterized by weakness in the shoulder-girdle and peroneal muscles.

• Arthrogryposis|Congenital articular rigidity with myopathy

  a rare, non-progressive congenital disorder characterized by multiple joint contractures which are present at birth.

• Childhood Idiopathic Inflammatory Myopathy|Childhood IIM|JIIM|Juvenile Idiopathic Inflammatory Myopathy

  an idiopathic inflammatory myopathy that occurs during childhood.

• Dilated Cardiomyopathy-1E|CMD1E

  dilated cardiomyopathy inherited in an autosomal dominant pattern caused by mutation(s) in the scn5a gene, encoding sodium channel protein type 5 subunit alpha.

• Idiopathic Inflammatory Myopathy|IIM|IIM|Idiopathic Inflammatory Myopathies|Idiopathic Inflammatory Myopathies|Idiopathic Inflammatory Myositis

  an umbrella term for diseases which have chronic muscle inflammation and weakness of unknown etiology. the types of idiopathic inflammatory myopathy are further defined by either clinicopathologic criteria or by the presence of certain autoantibodies.

• MYH7 wt Allele|CMD1S|CMH1|CMYO7A|CMYO7B|CMYP7A|CMYP7B|Cardiac Muscle Myosin Heavy Chain 7 Beta Gene|MPD1|MYHCB|MyHC-Slow Gene|Myopathy, Distal 1 Gene|Myosin 7 Gene|Myosin Heavy Chain 7 wt Allele|Myosin Heavy Chain Beta-Subunit Gene|Myosin, Cardiac, Heavy Chain, Beta Gene|Myosin, Heavy Chain 7, Cardiac Muscle, Beta Gene|Myosin, Heavy Polypeptide 7, Cardiac Muscle, Beta Gene|Rhabdomyosarcoma Antigen MU-RMS-40.7A Gene|SPMD|SPMM

  human myh7 wild-type allele is located in the vicinity of 14q11.2 and is approximately 23 kb in length. this allele, which encodes myosin-7 protein, plays a role in thick filament formation and muscle contraction. mutations in the gene are associated with dilated cardiomyopathy 1s (left ventricular noncompaction 5), hypertrophic cardiomyopathy 1, laing distal myopathy, and myosin storage congenital myopathy types 7a (autosomal dominant) and 7b (autosomal recessive).

• Myofibrillar Myopathy 6|BAG3-Related Myofibrillar Myopathy|MFM6|Muscular Dystrophy, Selcen Type

  an autosomal dominant subtype of myofibrillar myopathy caused by mutation(s) in the bag3 gene, encoding bag family molecular chaperone regulator 3.

• Neurodevelopmental Disorder with Cardiomyopathy, Spasticity, and Brain Abnormalities|NEDCASB

  an autosomal recessive condition caused by mutation(s) in the shmt2 gene, encoding serine hydroxymethyltransferase, mitochondrial. it is characterized by global neurodevelopmental delay, severely impaired intellectual development, poor overall growth, and spasticity of the lower limbs. most affected individuals also have progressive hypertrophic cardiomyopathy in childhood or cardiac developmental anomalies.

• Toxic Dilated Cardiomyopathy|Dilated cardiomyopathy secondary to toxic reaction

  dilated cardiomyopathy secondary to exposure to a toxin.

Muscle Disorders

Your muscles help you move and help your body work. Different types of muscles have different jobs. There are many problems that can affect muscles. Muscle disorders can cause weakness, pain or even paralysis.

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