2026 ICD-10-CM Diagnosis Code E89.3Postprocedural hypopituitarism

ICD-10-CM Codes›E00–E89›E89›E89

ICD-10-CM E89.3
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E89.3 is a billable ICD-10-CM diagnosis code for postprocedural hypopituitarism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. Coders also document this condition as disorder of brain due to and following radiotherapy. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Postprocedural or postoperative endocrine or metabolic complication.

Code Identity

ICD-10-CM Code
E89.3
Billable Status
Yes — Valid for Submission
Code Describes
Postprocedural hypopituitarism
Short Description
Postprocedural hypopituitarism
Same as the full description in the CMS dataset.
Parent Code
E89
Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE89Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified
CategoryE89Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified
This CodeE89.3Postprocedural hypopituitarism

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Disorder of brain due to and following radiotherapy
  • Hypophysectomy-induced hypopituitarism
  • Hypopituitarism due to radiotherapy
  • Hypopituitarism following procedure

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Postirradiation hypopituitarism

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Absence(of) (organ or part) (complete or partial)
      • pituitary gland (congenital)
        • acquired
    • Complication(s) (from) (of)
      • endocrine
        • postprocedural
          • hypopituitarism
    • Complication(s) (from) (of)
      • surgical procedure (on)
        • hypopituitarism (posthypophysectomy)
    • Disorder(of)
      • pituitary gland
        • iatrogenic (postprocedural)
    • Hypopituitarism(juvenile)
      • due to
        • hypophysectomy
    • Hypopituitarism(juvenile)
      • due to
        • radiotherapy
    • Hypopituitarism(juvenile)
      • postirradiation
    • Hypopituitarism(juvenile)
      • postprocedural

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END014
Postprocedural or postoperative endocrine or metabolic complication
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E89.3 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
253.7 Iatrogenic pituitary dis
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E89.3Overview

Is E89.3 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report postprocedural hypopituitarism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E89.3 group to?

When postprocedural hypopituitarism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E89.3?

Under the General Equivalence Mappings, postprocedural hypopituitarism converts to ICD-9-CM 253.7 (iatrogenic pituitary dis). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.