2026 ICD-10-CM Diagnosis Code E16.2Hypoglycemia, unspecified
ICD-10-CM Codes›E00–E89›E15-E16›E16
- Billable — Valid for Submission
- Not Chronic
E16.2 is a billable ICD-10-CM diagnosis code for hypoglycemia, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 640 through 641. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Adult onset non-insulinoma persistent hyperinsulinemic hypoglycemia
- Blood glucose below reference range
- Glucose level below reference range
- Glycopenia
- Hypoglycemia
- Hypoglycemia-induced convulsion
- Hypoglycemic disorder
- Hypoglycemic encephalopathy
- Hypoglycemic shock
- Hypoglycemic syndrome
- Neuropathy associated with hypoglycemia
- Nocturnal hypoglycemia
- Nocturnal hypoglycemia due to diabetes mellitus
- Non-diabetic hypoglycemia
- Random blood glucose outside reference range
- Random blood sugar below reference range
- Random glucose level abnormal
- Sequelae of endocrine disorders
- Situation-related seizures
- Spontaneous hypoglycemia
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Use Additional Code
- code for hypoglycemia level, if applicable E16.A
Type 1 Excludes
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Encephalopathy (acute) - G93.40
- hypoglycemic - E16.2
- Findings, abnormal, inconclusive, without diagnosis - See Also: Abnormal;
- blood sugar - R73.09
- low (transient) - E16.2
- Glycopenia - E16.2
- Hypoglycemia (spontaneous) - E16.2
- Polyneuropathy (peripheral) - G62.9
- hypoglycemia - E16.2
- Sugar
- blood
- low (transient) - E16.2
- Syndrome - See Also: Disease;
- hypoglycemic (familial) (neonatal) - E16.2
- McQuarrie's - E16.2
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Decrease(d)
- blood
- glucose
- Decrease(d)
- glucose
- Encephalopathy(acute)
- hypoglycemic
- Findings, abnormal, inconclusive, without diagnosis
- blood sugar
- low (transient)
- Glycopenia
- Hypoglycemia(spontaneous)
- McQuarrie's syndrome(idiopathic familial hypoglycemia)
- Polyneuropathy(peripheral)
- in (due to)
- hypoglycemia
- Sugar
- blood
- low (transient)
- Syndrome
- hypoglycemic (familial) (neonatal)
- Syndrome
- McQuarrie's
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Congenital Hyperinsulinism
a familial, nontransient hypoglycemia with defects in negative feedback of glucose-regulated insulin release. clinical phenotypes include hypoglycemia; hyperinsulinemia; seizures; coma; and often large birth weight. several sub-types exist with the most common, type 1, associated with mutations on an atp-binding cassette transporters (subfamily c, member 8).Hypoglycemia
a syndrome of abnormally low blood glucose level. clinical hypoglycemia has diverse etiologies. severe hypoglycemia eventually lead to glucose deprivation of the central nervous system resulting in hunger; sweating; paresthesia; impaired mental function; seizures; coma; and even death.
Patient EducationClinical
Hypoglycemia
Blood glucose, or blood sugar, is the main sugar found in your blood. It is your body's primary source of energy. It comes from the food you eat. Your body breaks down most of that food into glucose and releases it into your bloodstream. When your blood glucose goes up, it signals your pancreas to release insulin.
The full article covers:
- What is blood glucose?
- What is hypoglycemia?
- What causes hypoglycemia?
- What are the symptoms of hypoglycemia?
- How is hypoglycemia diagnosed?
- What are the treatments for hypoglycemia?
- Can hypoglycemia be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E16.2 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E16.2Overview
Is E16.2 (Other disorders of pancreatic internal secretion) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report hypoglycemia, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E16.2 group to?
When hypoglycemia, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 640, 641, with relative weights from 0.7782 to 1.3356 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E16.2?
Under the General Equivalence Mappings, hypoglycemia, unspecified converts to ICD-9-CM 251.2 (hypoglycemia NOS). The mapping is a direct match.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
