2026 ICD-10-CM Diagnosis Code D68.59Other primary thrombophilia
ICD-10-CM Codes›D50–D89›D65-D69›D68
- Billable — Valid for Submission
- Chronic Condition
D68.59 is a billable ICD-10-CM diagnosis code for other primary thrombophilia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Coagulation and hemorrhagic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acquired antithrombin III deficiency
- Acquired heparin cofactor II deficiency
- Acquired protein C deficiency
- Acquired protein S deficiency
- Antithrombin III deficiency
- Cerebral ischemic stroke due to hypercoagulable state
- Fibrinogen in blood above reference range
- Heparin cofactor II deficiency
- Hereditary antithrombin III deficiency
- Hereditary elevated factor VIII
- Hereditary elevated factor XI
- Hereditary heparin cofactor II deficiency
- Hereditary hyperfibrinogenemia
- Hereditary protein C deficiency
- Hereditary protein S deficiency
- Hereditary thrombophilia
- Hereditary thrombophilia due to congenital histidine-rich glycoprotein deficiency
- Heterozygous protein C deficiency
- Heterozygous protein S deficiency
- Homozygous protein C deficiency
- Homozygous protein S deficiency
- Hypercoagulability state
- Hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency
- Hyperfibrinogenemia
- Protein C deficiency disease
- Protein S deficiency disease
- Thrombophilia
- Thrombotic tendency observations
- Upper gastrointestinal hemorrhage associated with hypercoagulability state
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Antithrombin III deficiency
- Hypercoagulable state NOS
- Primary hypercoagulable state NEC
- Primary thrombophilia NEC
- Protein C deficiency
- Protein S deficiency
- Thrombophilia NOS
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- antithrombin (antithrombin III) - D68.59
- Hypercoagulable (state) - D68.59
- antithrombin (III) deficiency - D68.59
- primary NEC - D68.59
- protein C deficiency - D68.59
- protein S deficiency - D68.59
- Hypercoagulation (state) - D68.59
- Thrombophilia - D68.59
- primary NEC - D68.59
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Deficiency, deficient
- antithrombin (antithrombin III)
- Deficiency, deficient
- protein
- C
- Deficiency, deficient
- protein
- S
- Hypercoagulable(state)
- Hypercoagulable(state)
- antithrombin (III) deficiency
- Hypercoagulable(state)
- primary NEC
- Hypercoagulable(state)
- protein C deficiency
- Hypercoagulable(state)
- protein S deficiency
- Hypercoagulation(state)
- Thrombophilia
- Thrombophilia
- primary NEC
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Thrombophilia
a disorder of hemostasis in which there is a tendency for the occurrence of thrombosis.Antithrombin III Deficiency
an absence or reduced level of antithrombin iii leading to an increased risk for thrombosis.Antithrombin III Deficiency
a rare disorder characterized by the presence of low levels of antithrombin iii which prohibits the formation of blood clots. it may be inherited, usually in an autosomal dominant pattern, or acquired. it may lead to venous thrombosis and pulmonary embolism.
Patient EducationClinical
Bleeding Disorders
Normally, if you get hurt, your body forms a blood clot to stop the bleeding. For blood to clot, your body needs cells called platelets and proteins known as clotting factors. If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D68.59 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D68.59Overview
Is D68.59 (Primary thrombophilia) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other primary thrombophilia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D68.59 group to?
When other primary thrombophilia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D68.59?
Under the General Equivalence Mappings, other primary thrombophilia converts to ICD-9-CM 289.81 (prim hypercoagulable st). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
