2026 ICD-10-CM Diagnosis Code D64.81Anemia due to antineoplastic chemotherapy
ICD-10-CM Codes›D50–D89›D60-D64›D64
- Billable — Valid for Submission
- Chronic Condition
D64.81 is a billable ICD-10-CM diagnosis code for anemia due to antineoplastic chemotherapy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. Coders also document this condition as anemia caused by antineoplastic agent. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Aplastic anemia and Conditions due to neoplasm or the treatment of neoplasm.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Anemia caused by antineoplastic agent
- Anemia due to and following chemotherapy
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Antineoplastic chemotherapy induced anemia
Type 2 Excludes
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- due to (in) (with)
- antineoplastic chemotherapy
- Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- due to (in) (with)
- chemotherapy, antineoplastic
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Anemia
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D64.81 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D64.81Overview
Is D64.81 (Other specified anemias) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report anemia due to antineoplastic chemotherapy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D64.81 group to?
When anemia due to antineoplastic chemotherapy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D64.81?
Under the General Equivalence Mappings, anemia due to antineoplastic chemotherapy converts to ICD-9-CM 285.3 (anemia d/t antineo chemo). The mapping is a direct match.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
