2026 ICD-10-CM Diagnosis Code D58.2Other hemoglobinopathies

ICD-10-CM Codes›D50–D89›D55-D59›D58

ICD-10-CM D58.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D58.2 is a billable ICD-10-CM diagnosis code for other hemoglobinopathies. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.

Code Identity

ICD-10-CM Code
D58.2
Billable Status
Yes — Valid for Submission
Code Describes
Other hemoglobinopathies
Short Description
Other hemoglobinopathies
Same as the full description in the CMS dataset.
Parent Code
D58
Other hereditary hemolytic anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD58Other hereditary hemolytic anemias
This CodeD58.2Other hemoglobinopathies

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired hemoglobinopathy
  • Acquired pseudoxanthoma elasticum
  • Central cyanosis
  • Hemoglobin C disease
  • Hemoglobin C trait
  • Hemoglobin D disease
  • Hemoglobin D trait
  • Hemoglobin E disease
  • Hemoglobin E trait
  • Hemoglobin Iraq-Halabja trait
  • Hemoglobin O-Arab trait
  • Hemoglobin Zurich disease
  • Hemoglobinopathy
  • Hemoglobinopathy Toms River
  • Hemoglobinopathy with cyanosis
  • Hemoglobinopathy with erythrocytosis
  • Hereditary hemoglobinopathy
  • Hereditary hemoglobinopathy due to globin chain mutation
  • Heterozygous hemoglobinopathy
  • High affinity hemoglobin
  • Homozygous hemoglobinopathy
  • Low affinity hemoglobin
  • Mixed hemoglobin disorder
  • Osteonecrosis due to hemoglobinopathy
  • Osteonecrosis of ankle due to hemoglobinopathy
  • Osteonecrosis of bone of forearm due to hemoglobinopathy
  • Osteonecrosis of femur due to hemoglobinopathy
  • Osteonecrosis of foot due to hemoglobinopathy
  • Osteonecrosis of hand due to hemoglobinopathy
  • Osteonecrosis of humerus
  • Osteonecrosis of humerus due to hemoglobinopathy
  • Osteonecrosis of lower leg due to hemoglobinopathy
  • Osteonecrosis of multiple sites due to hemoglobinopathy
  • Osteonecrosis of pelvic region due to hemoglobinopathy
  • Osteonecrosis of pelvis
  • Osteonecrosis of shoulder region due to hemoglobinopathy
  • Pseudoxanthoma elasticum
  • Pseudoxanthoma elasticum due to hemoglobinopathy
  • Unstable hemoglobin disease

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Abnormal hemoglobin NOS
  • Congenital Heinz body anemia
  • Hb-C disease
  • Hb-D disease
  • Hb-E disease
  • Hemoglobinopathy NOS
  • Unstable hemoglobin hemolytic disease

Type 1 Excludes

  • familial polycythemia D75.0
  • Hb-M disease D74.0
  • hemoglobin E-beta thalassemia D56.5
  • hereditary persistence of fetal hemoglobin HPFH D56.4
  • high-altitude polycythemia D75.1
  • methemoglobinemia D74
  • other hemoglobinopathies with thalassemia D56.8

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Abnormal, abnormality, abnormalities
      • hemoglobin (disease)
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • congenital
        • Heinz body
    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • Heinz body, congenital
    • Arthritis, arthritic(acute) (chronic) (nonpyogenic) (subacute)
      • in (due to)
        • hemoglobinopathy NEC
    • Arthropathy
      • in (due to)
        • hemoglobinopathy NEC
    • Disease, diseased
      • hemoglobin or Hb
        • abnormal (mixed) NEC
    • Disease, diseased
      • hemoglobin or Hb
        • C (Hb-C)
    • Disease, diseased
      • hemoglobin or Hb
        • C (Hb-C)
          • with other abnormal hemoglobin NEC
    • Disease, diseased
      • hemoglobin or Hb
        • Constant Spring
    • Disease, diseased
      • hemoglobin or Hb
        • D (Hb-D)
    • Disease, diseased
      • hemoglobin or Hb
        • E (Hb-E)
    • Disease, diseased
      • hemoglobin or Hb
        • unstable, hemolytic
    • Disease, diseased
      • hemolytic (newborn)
        • unstable hemoglobin
    • Heinz body anemia, congenital
    • Hemoglobin
      • Constant Spring
    • Hemoglobinopathy(mixed)
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • carpus
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • clavicle
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • femur
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • fibula
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • finger
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • humerus
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • ilium
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • ischium
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • metacarpus
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • metatarsus
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • multiple sites
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • neck
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • radius
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • rib
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • scapula
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • skull
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • specified NEC
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • tarsus
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • tibia
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • toe
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • ulna
    • Osteonecrosis
      • secondary NEC
        • due to
          • hemoglobinopathy NEC
            • vertebra
    • Trait(s)
      • hemoglobin
        • abnormal NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD002
Hemolytic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hemoglobinopathies

    a group of inherited disorders characterized by structural alterations within the hemoglobin molecule.

  • Pseudoxanthoma Elasticum

    an inherited disorder of connective tissue with extensive degeneration and calcification of elastic tissue primarily in the skin, eye, and vasculature. at least two forms exist, autosomal recessive and autosomal dominant. this disorder is caused by mutations of one of the atp-binding cassette transporters. patients are predisposed to myocardial infarction and gastrointestinal hemorrhage.

  • Hemoglobin C Disease

    a disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. there may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.

  • Hemoglobin E Disease

    a condition characterized by the presence of a variant of normal hemoglobin (hemoglobin e), which is caused by mutation(s) in the gene encoding the beta subunit of the hemoglobin molecule.

  • Sickle Cell-Hemoglobin E Disease|Hemoglobin SE Disease

    a variant of sickle cell disease due to heterozygosity for hemoglobin s and hemoglobin e mutations. patients present with the symptoms of sickle cell disease but the symptoms are less frequent and severe compared to patients with hemoglobin ss disease.

  • ABCC6 wt Allele|ABC34|ARA|ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 wt Allele|ATP-Binding Cassette, Subfamily C, Member 6 Gene|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|Pseudoxanthoma Elasticum Gene|URG7

    human abcc6 wild-type allele is located in the vicinity of 16p13.1 and is approximately 75 kb in length. this allele, which encodes multidrug resistance-associated protein 6, plays a role in the active transport of drugs across the plasma membrane. mutation of the gene is associated with pseudoxanthoma elasticum and generalized arterial calcification of infancy type 2.

  • Pseudoxanthoma Elasticum

    a rare, progressive, autosomal recessive inherited disorder caused by mutations in the abcc6 gene. it is characterized by calcification and fragmentation of the elastic fibers of the skin, retina, and cardiovascular system. signs and symptoms include skin plaques and bumps, thickened skin, retinal hemorrhage and obstruction of the blood vessels.

  • Spastic Paraplegia 56|Autosomal Recessive Spastic Paraplegia-56 with or without Pseudoxanthoma Elasticum|SPG56

    an autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the cyp2u1 gene, encoding cytochrome p450 2u1.

  • Hemoglobin C Disease

    an autosomal recessive hemoglobinopathy with a mild clinical course. most patients are asymptomatic. when symptoms appear, they include mild hemolytic anemia and occasionally jaundice.

  • Sickle Cell-Hemoglobin C Disease|HbSC|Hemoglobin SC Disease|Hemoglobin SC Disease

    a hemoglobinopathy that is considered a hybrid of sickle cell disease and hemoglobin c disease. patients present with the symptoms of sickle cell disease but the latter are less frequent and severe compared to sickle cell disease.

  • Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease|Vaso-Occlusive Crisis in Hemoglobin SC Disease|Vaso-Occlusive Crisis of Hemoglobin SC Disease|Vaso-Occlusive Crisis of Sickle Cell-Hemoglobin C Disease

    sickle cell-hemoglobin c disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D58.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
282.7 Hemoglobinopathies NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D58.2Overview

Is D58.2 (Other hereditary hemolytic anemias) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other hemoglobinopathies on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D58.2 group to?

When other hemoglobinopathies is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D58.2?

Under the General Equivalence Mappings, other hemoglobinopathies converts to ICD-9-CM 282.7 (hemoglobinopathies NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.