2027 ICD-10-CM Diagnosis Code D49.81Neoplasm of unspecified behavior of retina and choroid

ICD-10-CM Codes›C00–D49›D49›D49

ICD-10-CM D49.81
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D49.81 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of retina and choroid. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 826 through 830, 843 through 845. Coders also document this condition as chorioretinal neoplasm. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.

Code Identity

ICD-10-CM Code
D49.81
Billable Status
Yes — Valid for Submission
Code Describes
Neoplasm of unspecified behavior of retina and choroid
Short Description
Neoplasm of unspecified behavior of retina and choroid
Same as the full description in the CMS dataset.
Parent Code
Neoplasm of unspecified behavior of other specified sites

Code Classification

ChapterC00–D49Neoplasms
SectionD49Neoplasms of unspecified behavior
CategoryD49Neoplasms of unspecified behavior
This CodeD49.81Neoplasm of unspecified behavior of retina and choroid

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Chorioretinal neoplasm
  • Neoplasm of choroid
  • Neoplasm of retina

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D49.81: its own notes plus those printed at D49.8, D49, and Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • 'growth' NOS
  • neoplasm NOS
  • new growth NOS
  • tumor NOS

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Dark area on retina
  • Retinal freckle

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From D49.8 Neoplasm of unspecified behavior of other specified sites applies to 2 codes
  • neoplasm of unspecified behavior of eyelid (skin) (D49.2)
  • neoplasm of unspecified behavior of eyelid cartilage (D49.2)
  • neoplasm of unspecified behavior of great vessels (D49.2)
  • neoplasm of unspecified behavior of optic nerve (D49.7)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • neoplasms of uncertain behavior (D37-D44, D48)

Notes

General instructions on how these codes are used.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes
  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D49.81, its category, or a range that includes it.

Excludes1 8

These codes carry an Excludes1 note naming D49.81: they are not reported together with it, unless the two conditions are unrelated.

  • C69.2 Malignant neoplasm of retina
    dark area on retina (D49.81)
  • C69.2 Malignant neoplasm of retina
    neoplasm of unspecified behavior of retina and choroid (D49.81)
  • C69.2 Malignant neoplasm of retina
    retinal freckle (D49.81)
  • D31.2 Benign neoplasm of retina
    dark area on retina (D49.81)
  • D31.2 Benign neoplasm of retina
    hemangioma of retina (D49.81)
  • D31.2 Benign neoplasm of retina
    neoplasm of unspecified behavior of retina and choroid (D49.81)
  • D31.2 Benign neoplasm of retina
    retinal freckle (D49.81)
  • Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
    neoplasms of unspecified behavior (D49.-) names D49.-, which includes this code

Notes 1

These notes mention D49.81.

  • D49 Neoplasms of unspecified behavior
    Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth. names D49, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO072
Neoplasms of unspecified nature or uncertain behavior
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary
Malig.
Secondary
Ca
in situ
BenignUncertainUnspec.
choroidC69.3C79.49D09.2D31.3D48.7D49.81
retinaC69.2C79.49D09.2D31.2D48.7D49.81

Patient EducationClinical

Retinal Disorders

Retinal disorders are conditions that affect the retina, the thin light-sensitive tissue at the back of your eye. The retina senses light and sends signals to your brain so you can see.

The full article covers:

  • What are retinal disorders?
  • What causes retinal disorders?
  • What are common retinal disorders?
  • What are the symptoms of retinal disorders?
  • How are retinal disorders diagnosed?
  • How are retinal disorders treated?
  • Can retinal disorders be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D49.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
239.81 Neo retina/choroid NOS
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D49.81Overview

What is the ICD-10 code for neoplasm of unspecified behavior of retina and choroid?

The ICD-10-CM code for neoplasm of unspecified behavior of retina and choroid is D49.81 (sometimes written as D4981). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is D49.81 (Neoplasm of unspecified behavior of other specified sites) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of retina and choroid on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D49.81 group to?

When neoplasm of unspecified behavior of retina and choroid is the principal diagnosis on an inpatient stay, it groups to MS-DRG 844, 827, 829, 843, 828, 826, 830, 845, with relative weights from 0.8443 to 4.7560 depending on complications. Higher weights mean higher Medicare reimbursement.

Can D49.81 be reported with D49.2?

Not as a rule. The Excludes1 note at D49.8, which applies to D49.81, lists "neoplasm of unspecified behavior of eyelid (skin) (D49.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of D49.81?

Under the General Equivalence Mappings, neoplasm of unspecified behavior of retina and choroid converts to ICD-9-CM 239.81 (neo retina/choroid NOS). The mapping is a direct match.