2027 ICD-10-CM Diagnosis Code C81.48Lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites
ICD-10-CM Codes›C00–D49›C81-C96›C81
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 21
- Chronic Condition
C81.48 is a billable ICD-10-CM diagnosis code for lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 820 through 825, 840 through 842. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 80 closely related codes. Coders also document this condition as Hodgkin's disease, lymphocytic-histiocytic predominance of lymph nodes of multiple sites. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hodgkin lymphoma.
For Medicare Advantage risk adjustment, C81.48 maps to CMS-HCC Category 21 (Lymphoma and Other Cancers) under the V28 model, adding a risk factor of about 0.671 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C81.48 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Hodgkin's disease, lymphocytic-histiocytic predominance of lymph nodes of multiple sites
- Lymphocyte-rich classical Hodgkin lymphoma
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to C81.48: its own notes plus those printed at C81.4, C81, block C81-C96, and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- nodular lymphocyte predominant Hodgkin lymphoma (C81.0-)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name C81.48, its category, or a range that includes it.
Applicable To 1
These notes mention C81.48.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Lymphocyte-Rich Classic Hodgkin Lymphoma
a subtype of classic hodgkin lymphoma with scattered hodgkin and reed-sternberg cells and a nodular or less often diffuse cellular background consisting of small lymphocytes and with an absence of neutrophils and eosinophils. (who, 2008)Hodgkin Disease
a malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. in the classical variant, giant usually multinucleate hodgkin's and reed-sternberg cells are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Patient EducationClinical
Hodgkin Lymphoma
Hodgkin lymphoma, also called Hodgkin disease, is a type of cancer that develops in the lymph system. Your lymph system is part of your immune system. It helps protect your body from infection and disease.
The full article covers:
- What is Hodgkin lymphoma?
- What causes Hodgkin lymphoma?
- Who is more likely to develop Hodgkin lymphoma?
- What are the symptoms of Hodgkin lymphoma?
- How is Hodgkin lymphoma diagnosed?
- What are the treatments for Hodgkin lymphoma?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C81.48 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C81.48Overview
What is the ICD-10 code for lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites?
The ICD-10-CM code for lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites is C81.48 (sometimes written as C8148). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is C81.48 (Lymphocyte-rich Hodgkin lymphoma) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does C81.48 group to?
When lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites is the principal diagnosis on an inpatient stay, it groups to MS-DRG 841, 821, 822, 825, 842, 824, 840, 820, 823, with relative weights from 0.9948 to 6.2454 depending on complications. Higher weights mean higher Medicare reimbursement.
Is C81.48 a CC or MCC?
CMS lists C81.48 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 80 closely related codes in its exclusion list.
Can C81.48 be reported with a code from C81.0?
Not as a rule. The Excludes1 note at C81.4, which applies to C81.48, lists "nodular lymphocyte predominant Hodgkin lymphoma (C81.0-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is C81.48?
C81.48 (lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites) maps to CMS-HCC Category 21 (Lymphoma and Other Cancers), commonly written as HCC 21, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 10 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 21.
Does C81.48 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C81.48 adds a risk adjustment factor of about 0.671 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.493 to 0.739 depending on the payment segment). A more severe related category (HCC 17, HCC 18, HCC 19, and HCC 20) supersedes it when both are reported. See the full factor table on the HCC 21 category page.
