2026 ICD-10-CM Diagnosis Code C81.25Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb

ICD-10-CM Codes›C00–D49›C81-C96›C81

ICD-10-CM C81.25
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

C81.25 is a billable ICD-10-CM diagnosis code for mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 820 through 825, 840 through 842. Coders also document this condition as hodgkin disease of lymph nodes of lower limb. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hodgkin lymphoma.

Code Identity

ICD-10-CM Code
C81.25
Billable Status
Yes — Valid for Submission
Code Describes
Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
Short Description
Mixed cellular Hdgkn lymph, nodes of ing rgn and lower limb
Parent Code
C81.2
Mixed cellularity Hodgkin lymphoma

Code Classification

ChapterC00–D49Neoplasms
SectionC81-C96Malignant neoplasms of lymphoid, hematopoietic and related tissue
CategoryC81Hodgkin lymphoma
This CodeC81.25Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hodgkin disease of lymph nodes of lower limb
  • Hodgkin disease, mixed cellularity of lymph nodes of lower limb
  • Hodgkin's disease, mixed cellularity

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO057
Hodgkin lymphoma
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Hodgkin Lymphoma

Hodgkin lymphoma, also called Hodgkin disease, is a type of cancer that develops in the lymph system. Your lymph system is part of your immune system. It helps protect your body from infection and disease.

The full article covers:

  • What is Hodgkin lymphoma?
  • What causes Hodgkin lymphoma?
  • Who is more likely to develop Hodgkin lymphoma?
  • What are the symptoms of Hodgkin lymphoma?
  • How is Hodgkin lymphoma diagnosed?
  • What are the treatments for Hodgkin lymphoma?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert C81.25 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
201.65 Hodgkins mix cell inguin
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About C81.25Overview

Is C81.25 (Mixed cellularity Hodgkin lymphoma) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does C81.25 group to?

When mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb is the principal diagnosis on an inpatient stay, it groups to MS-DRG 820, 821, 822, 823, 824, 825, 840, 841, 842, with relative weights from 1.0104 to 5.8648 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of C81.25?

Under the General Equivalence Mappings, mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb converts to ICD-9-CM 201.65 (hodgkins mix cell inguin). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.