2026 ICD-10-CM Diagnosis Code C48.2Malignant neoplasm of peritoneum, unspecified
ICD-10-CM Codes›C00–D49›C45-C49›C48
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 20
- Chronic Condition
C48.2 is a billable ICD-10-CM diagnosis code for malignant neoplasm of peritoneum, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 374 through 376. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 6 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Gastrointestinal cancers - peritoneum.
For Medicare Advantage risk adjustment, C48.2 maps to CMS-HCC Category 20 (Lung and Other Severe Cancers) under the V28 model, adding a risk factor of about 1.136 for a community, non-dual, aged beneficiary in payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C48.2 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2026.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Carcinoma of peritoneum
- Clear cell adenocarcinoma of peritoneum
- Extraovarian primary peritoneal carcinoma
- Leiomyosarcoma of connective tissue
- Liposarcoma of connective tissue
- Local recurrence of malignant neoplasm of peritoneum
- Malignant neoplasm of peritoneum
- Primary adenocarcinoma of peritoneum
- Primary clear cell adenocarcinoma of peritoneum
- Primary giant cell sarcoma of peritoneum
- Primary leiomyosarcoma of abdomen
- Primary leiomyosarcoma of peritoneum
- Primary liposarcoma of peritoneum
- Primary liposarcoma of soft tissue of abdomen
- Primary liposarcoma of soft tissue of trunk
- Primary malignant neoplasm of peritoneum
- Primary sarcoma of peritoneum
- Primary sarcoma of soft tissues of abdomen
- Sarcoma of peritoneum
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Table of NeoplasmsClinical
Patient EducationClinical
Cancer
Cancer is not just one disease but many diseases. Cancer begins in your cells, which are the building blocks of your body. Usually, your body forms new cells as needed, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should.
The full article covers:
- What is cancer?
- What are the types of cancer?
- How does cancer develop?
- What are the symptoms of cancer?
- How is cancer diagnosed?
- What are the treatments for cancer?
- Can cancer be prevented?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert C48.2 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C48.2Overview
What is the ICD-10 code for malignant neoplasm of peritoneum, unspecified?
The ICD-10-CM code for malignant neoplasm of peritoneum, unspecified is C48.2 (sometimes written as C482). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is C48.2 (Malignant neoplasm of retroperitoneum and peritoneum) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of peritoneum, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does C48.2 group to?
When malignant neoplasm of peritoneum, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 374, 375, 376, with relative weights from 0.9243 to 2.1387 depending on complications. Higher weights mean higher Medicare reimbursement.
Is C48.2 a CC or MCC?
CMS lists C48.2 as a CC (complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 6 closely related codes in its exclusion list.
What is the ICD-9 equivalent of C48.2?
Under the General Equivalence Mappings, malignant neoplasm of peritoneum, unspecified converts to ICD-9-CM 158.9 (mal neo peritoneum NOS). The mapping is a direct match.
What HCC is C48.2?
C48.2 (malignant neoplasm of peritoneum, unspecified) maps to CMS-HCC Category 20 (Lung and Other Severe Cancers), commonly written as HCC 20, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2026. It mapped to HCC 9 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 22.
Does C48.2 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C48.2 adds a risk adjustment factor of about 1.136 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.672 to 1.214 depending on the payment segment). A more severe related category (HCC 17, HCC 18, and HCC 19) supersedes it when both are reported. See the full factor table on the HCC 20 category page.
