2027 ICD-10-CM Diagnosis Code C48.0Malignant neoplasm of retroperitoneum
ICD-10-CM Codes›C00–D49›C45-C49›C48
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 20
- Chronic Condition
C48.0 is a billable ICD-10-CM diagnosis code for malignant neoplasm of retroperitoneum. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 826 through 830, 843 through 845. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 2 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Gastrointestinal cancers - all other types.
For Medicare Advantage risk adjustment, C48.0 maps to CMS-HCC Category 20 (Lung and Other Severe Cancers) under the V28 model, adding a risk factor of about 1.136 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
C48.0 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Liposarcoma of retroperitoneum
- Malignant neoplasm of perinephric tissue
- Malignant neoplasm of retrocecal tissue
- Malignant retroperitoneal neoplasm
- Malignant teratoma
- Malignant teratoma of retroperitoneum
- Neoplasm of periadrenal tissue
- Neoplasm of perirenal tissue
- Neoplasm of retrocecal tissue
- Primary giant cell sarcoma of retroperitoneum
- Primary leiomyosarcoma of abdomen
- Primary leiomyosarcoma of retroperitoneum
- Primary liposarcoma of retroperitoneum
- Primary malignant neoplasm of periadrenal tissue
- Primary malignant neoplasm of perirenal tissue
- Primary malignant neoplasm of retrocecal tissue
- Primary malignant neoplasm of retroperitoneum
- Primary sarcoma of retroperitoneum
- Retroperitoneal sarcoma
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to C48.0: its own notes plus those printed at C48 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Notes
General instructions on how these codes are used.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name C48.0, its category, or a range that includes it.
Applicable To 1
These notes mention C48.0.
- Z85.83 Personal history of malignant neoplasm of bone and soft tissue
Excludes1 2
These codes carry an Excludes1 note naming C48.0: they are not reported together with it, unless the two conditions are unrelated.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Malignant Retroperitoneal Neoplasm
a primary or metastatic malignant neoplasm involving the retroperitoneum. the vast majority of cases are carcinomas, lymphomas, or sarcomas.
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| connective tissue NEC › retroperitoneum | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
| paranephric | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
| periadrenal (tissue) | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
| perinephric | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
| peripancreatic | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
| perirenal (tissue) | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
| retrocecal | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
| retroperitoneal (space) (tissue) | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
| retroperitoneum | C48.0 | C78.6 | – | D20.0 | D48.3 | D49.0 |
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Convert C48.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About C48.0Overview
What is the ICD-10 code for malignant neoplasm of retroperitoneum?
The ICD-10-CM code for malignant neoplasm of retroperitoneum is C48.0 (sometimes written as C480). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is C48.0 (Malignant neoplasm of retroperitoneum and peritoneum) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report malignant neoplasm of retroperitoneum on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does C48.0 group to?
When malignant neoplasm of retroperitoneum is the principal diagnosis on an inpatient stay, it groups to MS-DRG 844, 827, 829, 843, 828, 826, 830, 845, with relative weights from 0.8443 to 4.7560 depending on complications. Higher weights mean higher Medicare reimbursement.
Is C48.0 a CC or MCC?
CMS lists C48.0 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 2 closely related codes in its exclusion list.
Can C48.0 be reported with C46.1?
Not as a rule. The Excludes1 note at C48, which applies to C48.0, lists "Kaposi's sarcoma of connective tissue (C46.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is C48.0?
C48.0 (malignant neoplasm of retroperitoneum) maps to CMS-HCC Category 20 (Lung and Other Severe Cancers), commonly written as HCC 20, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 9 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 22.
Does C48.0 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, C48.0 adds a risk adjustment factor of about 1.136 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.672 to 1.214 depending on the payment segment). A more severe related category (HCC 17, HCC 18, and HCC 19) supersedes it when both are reported. See the full factor table on the HCC 20 category page.
