2026 ICD-10-CM Diagnosis Code A52.8Late syphilis, latent

ICD-10-CM Codes›A00–B99›A50-A64›A52

ICD-10-CM A52.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

A52.8 is a billable ICD-10-CM diagnosis code for late syphilis, latent. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 867 through 869. Coders also document this condition as acquired syphilis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sexually transmitted infections (excluding HIV and hepatitis).

Code Identity

ICD-10-CM Code
A52.8
Billable Status
Yes — Valid for Submission
Code Describes
Late syphilis, latent
Short Description
Late syphilis, latent
Same as the full description in the CMS dataset.
Parent Code
A52
Late syphilis

Code Classification

ChapterA00–B99Certain infectious and parasitic diseases
SectionA50-A64Infections with a predominantly sexual mode of transmission
CategoryA52Late syphilis
This CodeA52.8Late syphilis, latent

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired syphilis
  • Acquired syphilis - late latent
  • Late latent syphilis
  • Late syphilis, latent
  • Latent syphilis
  • Latent syphilis with positive serology

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Syphilis (acquired) without clinical manifestations, with positive serological reaction and negative spinal fluid test, two years or more after infection

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Syphilis, syphilitic(acquired)
      • late
        • latent or 2 years or more after infection (without manifestations)
    • Syphilis, syphilitic(acquired)
      • late
        • latent or 2 years or more after infection (without manifestations)
          • negative spinal fluid test
    • Syphilis, syphilitic(acquired)
      • late
        • latent or 2 years or more after infection (without manifestations)
          • serology positive
    • Syphilis, syphilitic(acquired)
      • latent
        • follow-up of latent syphilis
          • late, or 2 years or more after infection
    • Syphilis, syphilitic(acquired)
      • latent
        • late, or 2 years or more after infection
    • Syphilis, syphilitic(acquired)
      • latent
        • positive serology (only finding)
          • late, or 2 years or more after infection

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INF010
Sexually transmitted infections (excluding HIV and hepatitis)
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Late Latent Syphilis

    latent syphilis when infection was acquired more than twelve months previously.

  • Early Latent Syphilis

    latent syphilis when infection was acquired less than twelve months previously.

  • Latent Syphilis

    a stage of syphilis characterized by the serologic evidence of infection by treponema pallidum without evidence of accompanying signs or symptoms related to the disease.

Patient EducationClinical

Syphilis

Syphilis is a sexually transmitted infection (STI) caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert A52.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
096 Late syphilis latent
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About A52.8Overview

Is A52.8 (Late syphilis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report late syphilis, latent on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does A52.8 group to?

When late syphilis, latent is the principal diagnosis on an inpatient stay, it groups to MS-DRG 867, 868, 869, with relative weights from 0.7297 to 2.0932 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of A52.8?

Under the General Equivalence Mappings, late syphilis, latent converts to ICD-9-CM 096 (late syphilis latent). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.