2026 ICD-10-CM Diagnosis Code A51.45Secondary syphilitic hepatitis

ICD-10-CM Codes›A00–B99›A50-A64›A51

ICD-10-CM A51.45
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

A51.45 is a billable ICD-10-CM diagnosis code for secondary syphilitic hepatitis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 441 through 443. Coders also document this condition as bacterial hepatitis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hepatitis and Sexually transmitted infections (excluding HIV and hepatitis).

Code Identity

ICD-10-CM Code
A51.45
Billable Status
Yes — Valid for Submission
Code Describes
Secondary syphilitic hepatitis
Short Description
Secondary syphilitic hepatitis
Same as the full description in the CMS dataset.
Parent Code
A51.4
Other secondary syphilis

Code Classification

ChapterA00–B99Certain infectious and parasitic diseases
SectionA50-A64Infections with a predominantly sexual mode of transmission
CategoryA51Early syphilis
This CodeA51.45Secondary syphilitic hepatitis

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Bacterial hepatitis
  • Hepatitis in secondary syphilis
  • Secondary syphilis of digestive system
  • Secondary syphilis of liver
  • Secondary syphilis of viscera

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Hepatitis
      • syphilitic (late)
        • secondary
    • Syphilis, syphilitic(acquired)
      • secondary (and primary)
        • hepatitis
    • Syphilis, syphilitic(acquired)
      • secondary (and primary)
        • liver

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INF007
Hepatitis
Default principal diagnosis: inpatient No · outpatient No
CCSR INF010
Sexually transmitted infections (excluding HIV and hepatitis)
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Secondary Syphilis

    the secondary stage of syphilis typically that is characterized by generalized rash (including palms and soles), mucocutaneous lesions, and lymphadenopathy. it usually begins one to two months after the primary stage.

Patient EducationClinical

Hepatitis

Hepatitis is inflammation of the liver. Inflammation is swelling that happens when tissues of the body are injured or infected. It can damage your liver. This swelling and damage can affect how well your liver functions.

The full article covers:

  • What is hepatitis?
  • What causes hepatitis?
  • How is viral hepatitis spread?
  • Who is at risk for hepatitis?
  • What are the symptoms of hepatitis?
  • What other problems can hepatitis cause?
  • How is hepatitis diagnosed?
  • What are the treatments for hepatitis?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert A51.45 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
091.62 Syphilitic hepatitis
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About A51.45Overview

Is A51.45 (Other secondary syphilis) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report secondary syphilitic hepatitis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does A51.45 group to?

When secondary syphilitic hepatitis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 441, 442, 443, with relative weights from 0.6997 to 1.7947 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of A51.45?

Under the General Equivalence Mappings, secondary syphilitic hepatitis converts to ICD-9-CM 091.62 (syphilitic hepatitis). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.