2027 ICD-10-CM Diagnosis Code Z88.3Allergy status to other anti-infective agents
Z88.3 is a billable ICD-10-CM diagnosis code for allergy status to other anti-infective agents. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 951. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for Z88.3.
Present on Admission (POA)Billing
Z88.3 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99).
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Allergy to abacavir
- Allergy to acetic acid
- Allergy to acridine derivative azo
- Allergy to acyclovir
- Allergy to adhesive agent
- Allergy to albendazole
- Allergy to aldehyde
- Allergy to amantadine
- Allergy to aminoquinoline
- Allergy to amodiaquine
- Allergy to amorolfine
- Allergy to amphotericin
- Allergy to atovaquone
- Allergy to azole
- Allergy to balsam of Peru
- Allergy to benzimidazole
- Allergy to benzoyl peroxide
- Allergy to benzyl benzoate
- Allergy to bephenium
- Allergy to biguanide
- Allergy to bismuth subnitrate and/or iodoform
- Allergy to borate
- Allergy to boric acid
- Allergy to brilliant green
- Allergy to carbamate
- Allergy to cetrimide
- Allergy to cetylpyridinium
- Allergy to chlorhexidine
- Allergy to chlorhexidine and/or neomycin
- Allergy to chlorinated phenol
- Allergy to chloroquine
- Allergy to chloroxylenol
- Allergy to clioquinol
- Allergy to clotrimazole
- Allergy to dapsone
- Allergy to darunavir
- Allergy to dequalinium
- Allergy to diamidine
- Allergy to dichloroacetamide
- Allergy to didanosine
- Allergy to diethylcarbamazine
- Allergy to diloxanide
- Allergy to domiphen
- Allergy to econazole
- Allergy to famciclovir
- Allergy to fenticonazole
- Allergy to fluconazole
- Allergy to flucytosine
- Allergy to fluoroquinolone
- Allergy to formaldehyde
- Allergy to foscarnet
- Allergy to ganciclovir
- Allergy to gentian violet
- Allergy to glutaraldehyde
- Allergy to griseofulvin
- Allergy to halofantrine
- Allergy to hexachlorophene
- Allergy to hexetidine
- Allergy to hydrargaphen
- Allergy to hydrogen peroxide
- Allergy to hydroxychloroquine
- Allergy to ichthammol
- Allergy to idoxuridine
- Allergy to imidazole
- Allergy to industrial methylated spirit
- Allergy to inosine pranobex
- Allergy to interferon
- Allergy to interferon alfa-2a
- Allergy to interferon alfa-2b
- Allergy to interferon alfa-n1
- Allergy to interferon gamma-1b
- Allergy to iodine compound
- Allergy to iodophore
- Allergy to isoconazole
- Allergy to itraconazole
- Allergy to ketoconazole
- Allergy to macrolide
- Allergy to mebendazole
- Allergy to mefloquine
- Allergy to metronidazole
- Allergy to miconazole
- Allergy to monosulfiram
- Allergy to nalidixic acid
- Allergy to natamycin
- Allergy to nevirapine
- Allergy to niclosamide
- Allergy to nimorazole
- Allergy to nitrofurantoin
- Allergy to nitroimidazole
- Allergy to nitrophenol
- Allergy to noxythiolin
- Allergy to nystatin
- Allergy to oxyquinoline
- Allergy to pentamidine
- Allergy to phenol
- Allergy to piperazine
- Allergy to polynoxylin
- Allergy to povidone iodine
- Allergy to primaquine
- Allergy to proguanil
- Allergy to protease inhibitor
- Allergy to pyrantel
- Allergy to pyrimethamine
- Allergy to quaternary ammonium surfactant
- Allergy to quaternary pyridinium surfactant
- Allergy to quaternary quinolinium surfactant
- Allergy to quinacrine
- Allergy to quinine
- Allergy to reverse transcriptase inhibitor
- Allergy to ribavirin
- Allergy to silver nitrate
- Allergy to sodium perborate
- Allergy to sodium stibogluconate
- Allergy to substance with triazole structure
- Allergy to sulconazole
- Allergy to sulfamethoxazole and/or trimethoprim
- Allergy to terbinafine
- Allergy to thiabendazole
- Allergy to thimerosal
- Allergy to tinidazole
- Allergy to tioconazole
- Allergy to tolnaftate
- Allergy to tree resin
- Allergy to triazole
- Allergy to triclosan
- Allergy to trifluridine
- Allergy to trimethoprim
- Allergy to undecenoate
- Allergy to valacyclovir
- Allergy to vidarabine
- Allergy to zalcitabine
- Allergy to zidovudine
- Hypersensitivity to abacavir
- Hypersensitivity to nalidixic acid
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to Z88.3: its own notes plus those printed at Z88, block Z77-Z99, and Chapter 21. A note printed at a category, block or chapter applies to every code under it.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Code Also
A second code may be needed to fully describe the condition; the note gives no sequencing direction.
Notes
General instructions on how these codes are used.
- Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
- (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
- (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name Z88.3, its category, or a range that includes it.
Excludes2 1
These codes carry an Excludes2 note naming Z88.3: its condition is not part of those codes, and both may be reported when the patient has both.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
personal (of) See Also: History, family (of);
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert Z88.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About Z88.3Overview
What is the ICD-10 code for allergy status to other anti-infective agents?
The ICD-10-CM code for allergy status to other anti-infective agents is Z88.3 (sometimes written as Z883). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is Z88.3 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report allergy status to other anti-infective agents on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does Z88.3 group to?
On inpatient claims, allergy status to other anti-infective agents maps to MS-DRG 951 (other Factors Influencing Health Status), which carries a relative weight of 0.5574. Higher weights mean higher Medicare reimbursement.
Can Z88.3 be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because allergy status to other anti-infective agents describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is Z88.3 exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for allergy status to other anti-infective agents on inpatient claims. The code appears in the Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99) range of the CMS exempt list.
