2026 ICD-10-CM Diagnosis Code Z88.3Allergy status to other anti-infective agents
Z88.3 is a billable ICD-10-CM diagnosis code for allergy status to other anti-infective agents. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified status.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for Z88.3.
Present on Admission (POA)Billing
Z88.3 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Allergy to abacavir
- Allergy to acetic acid
- Allergy to acridine derivative azo
- Allergy to acyclovir
- Allergy to adhesive agent
- Allergy to albendazole
- Allergy to aldehyde
- Allergy to amantadine
- Allergy to aminoquinoline
- Allergy to amodiaquine
- Allergy to amorolfine
- Allergy to amphotericin
- Allergy to atovaquone
- Allergy to azole
- Allergy to balsam of Peru
- Allergy to benzimidazole
- Allergy to benzoyl peroxide
- Allergy to benzyl benzoate
- Allergy to bephenium
- Allergy to biguanide
- Allergy to bismuth subnitrate and/or iodoform
- Allergy to borate
- Allergy to boric acid
- Allergy to brilliant green
- Allergy to carbamate
- Allergy to cetrimide
- Allergy to cetylpyridinium
- Allergy to chlorhexidine
- Allergy to chlorhexidine and/or neomycin
- Allergy to chlorinated phenol
- Allergy to chloroquine
- Allergy to chloroxylenol
- Allergy to clioquinol
- Allergy to clotrimazole
- Allergy to dapsone
- Allergy to darunavir
- Allergy to dequalinium
- Allergy to diamidine
- Allergy to dichloroacetamide
- Allergy to didanosine
- Allergy to diethylcarbamazine
- Allergy to diloxanide
- Allergy to domiphen
- Allergy to econazole
- Allergy to famciclovir
- Allergy to fenticonazole
- Allergy to fluconazole
- Allergy to flucytosine
- Allergy to fluoroquinolone
- Allergy to formaldehyde
- Allergy to foscarnet
- Allergy to ganciclovir
- Allergy to gentian violet
- Allergy to glutaraldehyde
- Allergy to griseofulvin
- Allergy to halofantrine
- Allergy to hexachlorophene
- Allergy to hexetidine
- Allergy to hydrargaphen
- Allergy to hydrogen peroxide
- Allergy to hydroxychloroquine
- Allergy to ichthammol
- Allergy to idoxuridine
- Allergy to imidazole
- Allergy to industrial methylated spirit
- Allergy to inosine pranobex
- Allergy to interferon
- Allergy to interferon alfa-2a
- Allergy to interferon alfa-2b
- Allergy to interferon alfa-n1
- Allergy to interferon gamma-1b
- Allergy to iodine compound
- Allergy to iodophore
- Allergy to isoconazole
- Allergy to itraconazole
- Allergy to ketoconazole
- Allergy to macrolide
- Allergy to mebendazole
- Allergy to mefloquine
- Allergy to metronidazole
- Allergy to miconazole
- Allergy to monosulfiram
- Allergy to nalidixic acid
- Allergy to natamycin
- Allergy to nevirapine
- Allergy to niclosamide
- Allergy to nimorazole
- Allergy to nitrofurantoin
- Allergy to nitroimidazole
- Allergy to nitrophenol
- Allergy to noxythiolin
- Allergy to nystatin
- Allergy to organic phosphorus compound
- Allergy to oxyquinoline
- Allergy to pentamidine
- Allergy to phenol
- Allergy to piperazine
- Allergy to polynoxylin
- Allergy to povidone iodine
- Allergy to primaquine
- Allergy to proguanil
- Allergy to protease inhibitor
- Allergy to pyrantel
- Allergy to pyrimethamine
- Allergy to quaternary ammonium surfactant
- Allergy to quaternary pyridinium surfactant
- Allergy to quaternary quinolinium surfactant
- Allergy to quinacrine
- Allergy to quinine
- Allergy to reverse transcriptase inhibitor
- Allergy to ribavirin
- Allergy to silver nitrate
- Allergy to sodium perborate
- Allergy to sodium stibogluconate
- Allergy to substance with triazole structure
- Allergy to sulconazole
- Allergy to sulfamethoxazole and/or trimethoprim
- Allergy to terbinafine
- Allergy to thiabendazole
- Allergy to thimerosal
- Allergy to tinidazole
- Allergy to tioconazole
- Allergy to tolnaftate
- Allergy to triazole
- Allergy to triclosan
- Allergy to trifluridine
- Allergy to trimethoprim
- Allergy to undecenoate
- Allergy to valacyclovir
- Allergy to vidarabine
- Allergy to zalcitabine
- Allergy to zidovudine
- Hypersensitivity to abacavir
- Hypersensitivity to nalidixic acid
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- History
- personal (of) - See Also: History, family (of);
- allergy (to) - Z88.9
- anti-infective agent NEC - Z88.3
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- History
- personal (of)
- allergy (to)
- anti-infective agent NEC
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Drug Reactions
Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.
The full article covers:
- What is a drug interaction?
- What are side effects?
- What are drug allergies?
- How can I stay safe when taking medicines?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert Z88.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About Z88.3Overview
Is Z88.3 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report allergy status to other anti-infective agents on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Can Z88.3 be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because allergy status to other anti-infective agents describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
Is Z88.3 exempt from POA reporting?
Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for allergy status to other anti-infective agents on inpatient claims.
What is the ICD-9 equivalent of Z88.3?
Under the General Equivalence Mappings, allergy status to other anti-infective agents converts to ICD-9-CM V14.3 (hx-anti-infect allergy). The mapping is a direct match.
