2026 ICD-10-CM Diagnosis Code Z80.49Family history of malignant neoplasm of other genital organs

ICD-10-CM Codes›Z00–Z99›Z77-Z99›Z80

ICD-10-CM Z80.49
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z80.49 is a billable ICD-10-CM diagnosis code for family history of malignant neoplasm of other genital organs. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Family history of disease.

Code Identity

ICD-10-CM Code
Z80.49
Billable Status
Yes — Valid for Submission
Code Describes
Family history of malignant neoplasm of other genital organs
Short Description
Family history of malignant neoplasm of other genital organs
Same as the full description in the CMS dataset.
Parent Code
Z80.4
Family history of malignant neoplasm of genital organs

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategoryZ80Family history of primary malignant neoplasm
This CodeZ80.49Family history of malignant neoplasm of other genital organs

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z80.49.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z80.49 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Family history of malignant neoplasm of cervix uteri
  • Family history of malignant neoplasm of endometrium
  • Family history of malignant neoplasm of genital structure
  • Family history of malignant neoplasm of uterus
  • Family history of malignant neoplasm of vagina
  • FH: neoplasm of cervix
  • FH: neoplasm of female genital organ
  • FH: neoplasm of uterus

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • History
      • family (of)
        • malignant neoplasm (of) NOS
          • genital organ
    • History
      • family (of)
        • malignant neoplasm (of) NOS
          • genital organ
            • specified organ NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC028
Family history of disease
Default principal diagnosis: inpatient No · outpatient Yes

Patient EducationClinical

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Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Z80.49 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V16.40 Fm hx genital malig NOS
Approximate The match is approximate rather than exact.
ICD-9-CM
V16.49 Fm hx genital malig NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z80.49Overview

Is Z80.49 (Family history of malignant neoplasm of genital organs) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report family history of malignant neoplasm of other genital organs on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z80.49 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because family history of malignant neoplasm of other genital organs describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z80.49 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for family history of malignant neoplasm of other genital organs on inpatient claims.

What is the ICD-9 equivalent of Z80.49?

Under the General Equivalence Mappings, family history of malignant neoplasm of other genital organs converts to ICD-9-CM V16.40 (fm hx genital malig NOS) and V16.49 (fm hx genital malig NEC). The mapping is approximate, so confirm the match fits the documentation.