2027 ICD-10-CM Diagnosis Code Q96.4Mosaicism, 45, X/other cell line(s) with abnormal sex chromosome

ICD-10-CM Codes›Q00-Q99›Q90-Q99›Q96

ICD-10-CM Q96.4
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Q96.4 is a billable ICD-10-CM diagnosis code for mosaicism, 45, X/other cell line(s) with abnormal sex chromosome. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 742 through 743, 760 through 761. The code is exempt from POA reporting. Coders also document this condition as genetic mosaic. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Chromosomal abnormalities.

Code Identity

ICD-10-CM Code
Q96.4
Billable Status
Yes — Valid for Submission
Code Describes
Mosaicism, 45, X/other cell line(s) with abnormal sex chromosome
Short Description
Mosaic, 45, X/other cell line(s) w abnormal sex chromosome
Parent Code
Q96
Turner's syndrome

Code Classification

ChapterQ00-Q99Congenital malformations, deformations and chromosomal abnormalities
SectionQ90-Q99Chromosomal abnormalities, not elsewhere classified
CategoryQ96Turner's syndrome
This CodeQ96.4Mosaicism, 45, X/other cell line(s) with abnormal sex chromosome

Present on Admission (POA)Billing

Q96.4 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Chromosomal abnormalities, not elsewhere classified (Q90-Q99).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Genetic mosaic
  • Mosaic Turner syndrome
  • Mosaicism 45, X or other cell line with abnormal sex chromosome
  • Turner syndrome

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Q96.4: its own notes plus those printed at Q96, block Q90-Q99, and Chapter 17. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Q96 Turner's syndrome applies to 7 codes

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block Q90-Q99 Chromosomal abnormalities, not elsewhere classified applies to 74 codes
  • mitochondrial metabolic disorders (E88.4-)
From Chapter 17 (Q00-QA1) Congenital malformations, deformations and chromosomal abnormalities applies to 900 codes
  • inborn errors of metabolism (E70-E88)

Notes

General instructions on how these codes are used.

From Chapter 17 (Q00-QA1) Congenital malformations, deformations and chromosomal abnormalities applies to 900 codes
  • Codes from this chapter are not for use on maternal records

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Q96.4, its category, or a range that includes it.

Excludes1 7

These codes carry an Excludes1 note naming Q96.4: they are not reported together with it, unless the two conditions are unrelated.

  • E28.3 Primary ovarian failure
    Turner's syndrome (Q96.-) names Q96.-, which includes this code
  • Q50.0 Congenital absence of ovary
    Turner's syndrome (Q96.-) names Q96.-, which includes this code
  • Q97 Other sex chromosome abnormalities, female phenotype, not elsewhere classified
    Turner's syndrome (Q96.-) names Q96.-, which includes this code
  • E25 Adrenogenital disorders
    chromosomal abnormalities (Q90-Q99) names Q90-Q99, which includes this code
  • Block Q50-Q56 Congenital malformations of genital organs
    syndromes associated with anomalies in the number and form of chromosomes (Q90-Q99) names Q90-Q99, which includes this code
  • Q56 Indeterminate sex and pseudohermaphroditism
    pseudohermaphroditism with specified chromosomal anomaly (Q96-Q99) names Q96-Q99, which includes this code
  • Z15 Genetic susceptibility to disease
    chromosomal anomalies (Q90-Q99) names Q90-Q99, which includes this code

Code First 1

These codes say to code first a condition named in the note, and Q96.4 is one of the conditions named.

  • D84.81 Immunodeficiency due to conditions classified elsewhere
    chromosomal abnormalities (Q90-Q99) names Q90-Q99, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR MAL009
Chromosomal abnormalities
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Turner Syndrome

    a syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,x (or 45,xo). patients generally are of short stature with undifferentiated gonads (streak gonads), sexual infantilism, hypogonadism, webbing of the neck, cubitus valgus, elevated gonadotropins, decreased estradiol level in blood, and congenital heart defects. noonan syndrome (also called pseudo-turner syndrome and male turner syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.

Patient EducationClinical

Turner Syndrome

Turner syndrome is a genetic disorder that affects a girl's development and appearance. It can also cause health problems such as infertility and heart problems.

The full article covers:

  • What is Turner syndrome?
  • What causes Turner syndrome?
  • What are the symptoms of Turner syndrome?
  • How is Turner syndrome diagnosed?
  • What are the treatments for Turner syndrome?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert Q96.4 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
758.6 Gonadal dysgenesis
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Q96.4Overview

What is the ICD-10 code for mosaicism, 45, X/other cell line(s) with abnormal sex chromosome?

The ICD-10-CM code for mosaicism, 45, X/other cell line(s) with abnormal sex chromosome is Q96.4 (sometimes written as Q964). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is Q96.4 (Turner's syndrome) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report mosaicism, 45, X/other cell line(s) with abnormal sex chromosome on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does Q96.4 group to?

When mosaicism, 45, X/other cell line(s) with abnormal sex chromosome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 743, 760, 761, with relative weights from 0.7039 to 1.8448 depending on complications. Higher weights mean higher Medicare reimbursement.

Is Q96.4 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for mosaicism, 45, X/other cell line(s) with abnormal sex chromosome on inpatient claims. The code appears in the Chromosomal abnormalities, not elsewhere classified (Q90-Q99) range of the CMS exempt list.

Can Q96.4 be reported with Q87.19?

Not as a rule. The Excludes1 note at Q96, which applies to Q96.4, lists "Noonan syndrome (Q87.19)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).