2027 ICD-10-CM Diagnosis Code N14.19Nephropathy induced by other drugs, medicaments and biological substances

ICD-10-CM Codes›N00–N99›N10-N16›N14

ICD-10-CM N14.19
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

N14.19 is a billable ICD-10-CM diagnosis code for nephropathy induced by other drugs, medicaments and biological substances. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 698 through 700. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Nephritis; nephrosis; renal sclerosis.

N14.19 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model. It still risk-adjusts in the ESRD (V21) category 141 for payment year 2027.

Code Identity

ICD-10-CM Code
N14.19
Billable Status
Yes — Valid for Submission
Code Describes
Nephropathy induced by other drugs, medicaments and biological substances
Short Description
Nephropathy induced by other drug/meds/biol subst
Parent Code
N14.1
Nephropathy induced by other drugs, medicaments and biological substances

Code Classification

ChapterN00–N99Diseases of the genitourinary system
SectionN10-N16Renal tubulo-interstitial diseases
CategoryN14Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
This CodeN14.19Nephropathy induced by other drugs, medicaments and biological substances

Medicare Risk Adjustment (HCC)Billing

N14.19 does not risk-adjust for Medicare Advantage under the CMS-HCC V28 model, but it maps to payment categories in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
no payment category in the model that pays 100% of MA risk scores
Prior Model (CMS-HCC V24)
Not mapped under V24
this diagnosis newly risk-adjusts under the V28 model
Other CMS Models
ESRD (V21): HCC 141
ESRD V21 weights: 0.000 dialysis, 0.000 functioning graft
Part D (RxHCC)
Not mapped
N14.19 does not risk-adjust in the RxHCC prescription drug model

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Chronic cyclosporin A nephrotoxicity
  • Chronic drug-induced renal disease
  • Chronic lithium nephrotoxicity
  • Disorder of kidney caused by cisplatin
  • Drug-induced tubulointerstitial nephritis
  • Lithium nephropathy
  • Methyl CCNU nephropathy
  • Nephritis caused by drug
  • Nephropathy caused by heroin
  • Nephropathy induced by aminoglycoside
  • Nephropathy induced by amphotericin
  • Nephropathy induced by cyclosporine
  • Nephropathy induced by tacrolimus
  • Penicillamine nephropathy

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to N14.19: its own notes plus those printed at N14, block N10-N16, and Chapter 14. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From Block N10-N16 Renal tubulo-interstitial diseases applies to 35 codes
  • pyelonephritis

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Block N10-N16 Renal tubulo-interstitial diseases applies to 35 codes
  • pyeloureteritis cystica (N28.85)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 14 (N00-N99) Diseases of the genitourinary system applies to 838 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Code First

The underlying condition named in the note is sequenced before this code.

From N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions applies to 6 codes
  • poisoning due to drug or toxin, if applicable (T36-T65 with fifth or sixth character 1-4)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions applies to 6 codes
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name N14.19, its category, or a range that includes it.

Excludes2 1

These codes carry an Excludes2 note naming N14.19: its condition is not part of those codes, and both may be reported when the patient has both.

  • Block N17-N19 Acute kidney failure and chronic kidney disease
    drug- and heavy-metal-induced tubulo-interstitial and tubular conditions (N14.-) names N14.-, which includes this code

Code First 1

These codes say to code first a condition named in the note, and N14.19 is one of the conditions named.

  • Block T36-T50 Poisoning by, adverse effect of and underdosing of drugs, medicaments and biological substances
    nephropathy (N14.0-N14.2) names N14.0-N14.2, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR GEN001
Nephritis; nephrosis; renal sclerosis
Default principal diagnosis: inpatient No · outpatient No

Code History & ChangesHistory

Replacement N14.19 replaces the following previously assigned code(s):

  • N14.1 - Nephropathy induced by oth drug/meds/biol subst
FY 2023AddedAdded to the ICD-10-CM code setEffective October 1, 2022.
FY 2024–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About N14.19Overview

Is N14.19 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report nephropathy induced by other drugs, medicaments and biological substances on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does N14.19 group to?

When nephropathy induced by other drugs, medicaments and biological substances is the principal diagnosis on an inpatient stay, it groups to MS-DRG 699, 698, 700, with relative weights from 0.6740 to 1.6400 depending on complications. Higher weights mean higher Medicare reimbursement.

Can N14.19 be reported with N28.85?

Not as a rule. The Excludes1 note at block N10-N16, which applies to N14.19, lists "pyeloureteritis cystica (N28.85)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does N14.19 need an additional code?

When the condition applies, yes. The Use Additional Code note at N14, which applies to N14.19, reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). The additional code is reported after N14.19.

Does N14.19 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage: N14.19 maps to no category in the CMS-HCC V28 model. It still risk-adjusts in the ESRD (V21) category 141 (Nephritis).