2026 ICD-10-CM Diagnosis Code L51.2Toxic epidermal necrolysis [Lyell]

ICD-10-CM Codes›L00–L99›L49-L54›L51

ICD-10-CM L51.2
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

L51.2 is a billable ICD-10-CM diagnosis code for toxic epidermal necrolysis [Lyell]. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 595 through 596. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Allergic reactions and Other specified inflammatory condition of skin.

Code Identity

ICD-10-CM Code
L51.2
Billable Status
Yes — Valid for Submission
Code Describes
Toxic epidermal necrolysis [Lyell]
Short Description
Toxic epidermal necrolysis [Lyell]
Same as the full description in the CMS dataset.
Parent Code
L51
Erythema multiforme

Code Classification

ChapterL00–L99Diseases of the skin and subcutaneous tissue
SectionL49-L54Urticaria and erythema
CategoryL51Erythema multiforme
This CodeL51.2Toxic epidermal necrolysis [Lyell]

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Lyell syndrome
  • Stevens-Johnson syndrome, toxic epidermal necrolysis spectrum
  • Toxic epidermal necrolysis caused by drug
  • Toxic epidermal necrolysis due to graft-versus-host disease
  • Toxic epidermal necrolysis due to infection

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Epidermolysis
      • necroticans combustiformis
    • Lyell's syndrome
    • Lyell's syndrome
      • due to drug
    • Necrolysis, toxic epidermal

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ031
Allergic reactions
Default principal diagnosis: inpatient No · outpatient No
CCSR SKN002
Other specified inflammatory condition of skin
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Erythema Multiforme

    a skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with characteristic bull's-eye lesions usually occurring on the dorsal aspect of the hands and forearms.

Patient EducationClinical

Skin Conditions

Your skin is your body's largest organ. It covers the entire outside of your body. There are many ways that your skin protects your body and helps keep you healthy. For example, it:

The full article covers:

  • What does your skin do?
  • What problems and conditions can affect your skin?
  • How can I keep my skin healthy?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert L51.2 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
695.15 Toxic epidrml necrolysis
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About L51.2Overview

Is L51.2 (Erythema multiforme) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report toxic epidermal necrolysis [Lyell] on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does L51.2 group to?

When toxic epidermal necrolysis [Lyell] is the principal diagnosis on an inpatient stay, it groups to MS-DRG 595, 596, with relative weights from 1.0825 to 2.1207 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of L51.2?

Under the General Equivalence Mappings, toxic epidermal necrolysis [Lyell] converts to ICD-9-CM 695.15 (toxic epidrml necrolysis). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.