2026 ICD-10-CM Diagnosis Code I21.9Acute myocardial infarction, unspecified

ICD-10-CM CodesI00–I99I20-I25I21

ICD-10-CM I21.9
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

I21.9 is a billable ICD-10-CM diagnosis code for acute myocardial infarction, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 280 through 285. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Acute myocardial infarction.

Code Identity

ICD-10-CM Code
I21.9
Billable Status
Yes — Valid for Submission
Code Describes
Acute myocardial infarction, unspecified
Short Description
Acute myocardial infarction, unspecified
Same as the full description in the CMS dataset.
Parent Code
Acute myocardial infarction

Code Classification

ChapterI00–I99Diseases of the circulatory system
SectionI20-I25Ischemic heart diseases
CategoryI21Acute myocardial infarction
This CodeI21.9Acute myocardial infarction, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acute anteroapical myocardial infarction
  • Acute anteroseptal myocardial infarction
  • Acute infarction of papillary muscle
  • Acute myocardial infarction
  • Acute myocardial infarction due to left coronary artery occlusion
  • Acute myocardial infarction due to occlusion of circumflex branch of left coronary artery
  • Acute myocardial infarction due to right coronary artery occlusion
  • Acute myocardial infarction during procedure
  • Acute myocardial infarction of anterior wall
  • Acute myocardial infarction of anterior wall involving right ventricle
  • Acute myocardial infarction of anterolateral wall
  • Acute myocardial infarction of apex of heart
  • Acute myocardial infarction of apical-lateral wall
  • Acute myocardial infarction of atrium
  • Acute myocardial infarction of high lateral wall
  • Acute myocardial infarction of inferior wall
  • Acute myocardial infarction of inferior wall involving right ventricle
  • Acute myocardial infarction of inferolateral wall
  • Acute myocardial infarction of inferolateral wall with posterior extension
  • Acute myocardial infarction of inferoposterior wall
  • Acute myocardial infarction of lateral wall
  • Acute myocardial infarction of posterobasal wall
  • Acute myocardial infarction of posterolateral wall
  • Acute myocardial infarction of right ventricle
  • Acute myocardial infarction of septum
  • Acute posterior myocardial infarction
  • Acute Q wave myocardial infarction
  • Acute widespread myocardial infarction
  • Aneurysm of coronary vessels
  • Cardiac rupture due to and following acute myocardial infarction
  • Coronary artery embolism
  • Coronary artery perforation
  • Coronary artery rupture
  • Drug-related myocardial necrosis syndrome
  • EKG: myocardial infarction
  • First myocardial infarction
  • Mitral valve regurgitation due to acute myocardial infarction
  • Mitral valve regurgitation due to acute myocardial infarction with papillary muscle and chordal rupture
  • Mitral valve regurgitation due to acute myocardial infarction without papillary muscle and chordal rupture
  • Mixed myocardial ischemia and infarction
  • Myocardial infarction
  • Myocardial infarction due to atherothrombotic coronary artery disease
  • Myocardial infarction in recovery phase
  • Myocardial infarction with non-obstructive coronary artery
  • Myocardial necrosis
  • New myocardial infarction compared to prior study
  • Perforation of coronary artery co-occurrent and due to aneurysm of coronary artery
  • Pericarditis secondary to acute myocardial infarction
  • Postoperative acute myocardial infarction
  • Postoperative myocardial infarction
  • Pulmonary embolism due to and following acute myocardial infarction
  • Rupture of coronary artery co-occurrent and due to aneurysm of coronary artery
  • Rupture of ventricle due to acute myocardial infarction
  • True posterior myocardial infarction

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Myocardial infarction (acute) NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Infarct, infarction
      • myocardium, myocardial (acute) (with stated duration of 4 weeks or less)
    • Infarct, infarction
      • myocardium, myocardial (acute) (with stated duration of 4 weeks or less)
        • type 1

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR CIR009
Acute myocardial infarction
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Anterior Wall Myocardial Infarction

    myocardial infarction in which the anterior wall of the heart is involved. anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. it can be categorized as anteroseptal or anterolateral wall myocardial infarction.
  • Inferior Wall Myocardial Infarction

    myocardial infarction in which the inferior wall of the heart is involved. it is often caused by occlusion of the right coronary artery.
  • Kounis Syndrome

    a disorder of cardiac function secondary to hypersensitivity reactions. it is characterized by coexistence of acute coronary syndromes and cardiac mast cell and platelet activation. it may be induced by exposure to drugs (e.g., antibiotics, anesthetics, contrast media), food, and environmental triggers (e.g., insect bites and stings, poison ivy).
  • MINOCA

    myocardial infarction in the absence of obstructive coronary artery disease. coronary circulation disruption is due to various other factors such as atherosclerotic plaque and coronary vasospasm.
  • Myocardial Infarction

    necrosis of the myocardium caused by an obstruction of the blood supply to the heart (coronary circulation).
  • Non-ST Elevated Myocardial Infarction

    a myocardial infarction that does not produce elevations in the st segments of the electrocardiogram. st segment elevation of the ecg is often used in determining the treatment protocol (see also st elevation myocardial infarction).
  • Acute Myocardial Infarction by ECG Finding|ACUTE MYOCARDIAL INFARCTION|Acute Myocardial Infarction|Acute Myocardial Infarction by EKG Finding

    an electrocardiographic finding showing a current injury of the myocardium.
  • Acute Myocardial Infarction

    necrosis of the myocardium, as a result of interruption of the blood supply to the area. it is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations.
  • Acute Myocardial Infarction by ECG Finding|ACUTE MYOCARDIAL INFARCTION|Acute Myocardial Infarction|Acute Myocardial Infarction by EKG Finding

    an electrocardiographic finding showing a current of injury with st elevation. no specification is provided for localization. (cdisc)
  • Acute Myocardial Infarction From PCI Complication Type|PCI Acute Angiographic Complication|PCI Acute Angiographic Complication|PCI Acute Angiographic Complication|PCIAAC|PCIAAC

    a description of the complications from a percutaneous coronary intervention procedure that lead to an acute myocardial ischemic event.
  • Acute Myocardial Infarction Type|ACMITYPE|ACMITYPE

    a classification or description of the acute myocardial infarction.
  • Death due to Acute Myocardial Infarction Related to COVID-19|Death due to acute MI

    death by any cardiovascular mechanism (e.g., arrhythmia, sudden death, heart failure (hf), stroke, pulmonary embolus, peripheral arterial disease) less than or equal to 30 days after a myocardial infarction (mi), related to the immediate consequences of the mi, such as progressive hf or recalcitrant arrhythmia in a patient with probable or confirmed acute covid-19.
  • Coronary Artery Perforation

    a dissection that extends through the full thickness of the coronary arterial wall. (acc)

Patient EducationClinical

Heart Attack

Each year almost 800,000 Americans have a heart attack. A heart attack happens when blood flow to the heart suddenly becomes blocked. Without the blood coming in, the heart can't get oxygen. If not treated quickly, the heart muscle begins to die.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert I21.9 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
410.90 AMI NOS, unspecified
Approximate The match is approximate rather than exact.
ICD-9-CM
410.91 AMI NOS, initial
Approximate The match is approximate rather than exact.
ICD-9-CM
410.92 AMI NOS, subsequent
Approximate The match is approximate rather than exact.

Code History & ChangesHistory

Replacement I21.9 replaces the following previously assigned code(s):

  • I21.3 - ST elevation (STEMI) myocardial infarction of unsp site
FY 2018AddedAdded to the ICD-10-CM code setEffective October 1, 2017.
FY 2019–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About I21.9Overview

Is I21.9 (Acute myocardial infarction) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report acute myocardial infarction, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does I21.9 group to?

When acute myocardial infarction, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 280, 281, 282, 283, 284, 285, with relative weights from 0.5989 to 1.9808 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of I21.9?

Under the General Equivalence Mappings, acute myocardial infarction, unspecified converts to ICD-9-CM 410.90 (AMI NOS, unspecified), 410.91 (AMI NOS, initial), and 410.92 (AMI NOS, subsequent). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.