2027 ICD-10-CM Diagnosis Code G25.81Restless legs syndrome

ICD-10-CM Codes›G00–G99›G20-G26›G25

ICD-10-CM G25.81
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

G25.81 is a billable ICD-10-CM diagnosis code for restless legs syndrome. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 56 through 57. Coders also document this condition as restless leg syndrome due to iron deficiency anemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other nervous system disorders (often hereditary or degenerative) and Sleep wake disorders.

Code Identity

ICD-10-CM Code
G25.81
Billable Status
Yes — Valid for Submission
Code Describes
Restless legs syndrome
Short Description
Restless legs syndrome
Same as the full description in the CMS dataset.
Parent Code
G25.8
Other specified extrapyramidal and movement disorders

Code Classification

ChapterG00–G99Diseases of the nervous system
SectionG20-G26Extrapyramidal and movement disorders
CategoryG25Other extrapyramidal and movement disorders
This CodeG25.81Restless legs syndrome

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Restless leg syndrome due to iron deficiency anemia
  • Restless leg syndrome due to uremia
  • Restless leg syndrome in pregnancy
  • Restless legs syndrome
  • Secondary restless legs syndrome
  • Sleep related movement disorder

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to G25.81: its own notes plus those printed at G25 and Chapter 6. A note printed at a category, block or chapter applies to every code under it.

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From G25 Other extrapyramidal and movement disorders applies to 16 codes
  • sleep related movement disorders (G47.6-)
From Chapter 6 (G00-G99) Diseases of the nervous system applies to 700 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name G25.81, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming G25.81: they are not reported together with it, unless the two conditions are unrelated.

  • R25 Abnormal involuntary movements
    specific movement disorders (G20-G26) names G20-G26, which includes this code

Excludes2 2

These codes carry an Excludes2 note naming G25.81: its condition is not part of those codes, and both may be reported when the patient has both.

  • G47.6 Sleep related movement disorders
    restless legs syndrome (G25.81)
  • F98.4 Stereotyped movement disorders
    movement disorders of organic origin (G20-G25) names G20-G25, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NVS006
Other nervous system disorders (often hereditary or degenerative)
Default principal diagnosis: inpatient No · outpatient No
CCSR NVS016
Sleep wake disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Restless Legs Syndrome

    a disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.

Patient EducationClinical

Restless Legs

Restless legs syndrome (RLS) causes a powerful urge to move your legs. Your legs become uncomfortable when you are lying down or sitting. Some people describe it as a creeping, crawling, tingling, or burning sensation. Moving makes your legs feel better, but not for long. RLS can make it hard to fall asleep and stay asleep.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert G25.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
333.94 Restless legs syndrome
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About G25.81Overview

What is the ICD-10 code for restless legs syndrome?

The ICD-10-CM code for restless legs syndrome is G25.81 (sometimes written as G2581). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is G25.81 (Other specified extrapyramidal and movement disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report restless legs syndrome on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does G25.81 group to?

When restless legs syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 57, 56, with relative weights from 1.2835 to 2.2649 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of G25.81?

Under the General Equivalence Mappings, restless legs syndrome converts to ICD-9-CM 333.94 (restless legs syndrome). The mapping is a direct match.