2026 ICD-10-CM Diagnosis Code D82.4Hyperimmunoglobulin E [IgE] syndrome

ICD-10-CM Codes›D50–D89›D80-D89›D82

ICD-10-CM D82.4
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D82.4 is a billable ICD-10-CM diagnosis code for hyperimmunoglobulin E [IgE] syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. Coders also document this condition as autosomal dominant hyper-IgE syndrome due to STAT3 deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders.

Code Identity

ICD-10-CM Code
D82.4
Billable Status
Yes — Valid for Submission
Code Describes
Hyperimmunoglobulin E [IgE] syndrome
Short Description
Hyperimmunoglobulin E [IgE] syndrome
Same as the full description in the CMS dataset.
Parent Code
D82
Immunodeficiency associated with other major defects

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD82Immunodeficiency associated with other major defects
This CodeD82.4Hyperimmunoglobulin E [IgE] syndrome

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
  • Autosomal recessive hyper-IgE syndrome due to ZNF341 deficiency
  • CADINS disease
  • Hyperimmunoglobulin E syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Syndrome
      • hyperimmunoglobulin E (IgE)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

The full article covers:

  • What is the immune system?
  • What are the parts of the immune system?
  • How does the immune system work?
  • What are the types of immunity?
  • What can go wrong with the immune system?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D82.4 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
279.8 Immune mechanism dis NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D82.4Overview

Is D82.4 (Immunodeficiency associated with other major defects) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hyperimmunoglobulin E [IgE] syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D82.4 group to?

When hyperimmunoglobulin E [IgE] syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D82.4?

Under the General Equivalence Mappings, hyperimmunoglobulin E [IgE] syndrome converts to ICD-9-CM 279.8 (immune mechanism dis NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.