2026 ICD-10-CM Diagnosis Code D59.39Other hemolytic-uremic syndrome
ICD-10-CM Codes›D50–D89›D55-D59›D59
- Billable — Valid for Submission
- Not Chronic
D59.39 is a billable ICD-10-CM diagnosis code for other hemolytic-uremic syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. Coders also document this condition as anemia due to mechanical damage. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Anemia due to mechanical damage
- Atypical hemolytic uremic syndrome
- Atypical hemolytic uremic syndrome with anti-factor H antibodies
- Atypical hemolytic uremic syndrome with complement gene abnormality
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Atypical (nongenetic) hemolytic uremic syndrome
- Secondary hemolytic-uremic syndrome
Code First
- , if applicable, any associated:
- COVID-19 (U07.1)
- complications of kidney transplant T86.1
- complications of heart transplant T86.2
- complications of liver transplant T86.4
Code Also
- , if applicable, any associated condition, such as:
- hypertensive emergency I16.1
- malignant neoplasm C00 C96
- systemic lupus erythematosus M32
Use Additional Code
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Syndrome - See Also: Disease;
- atypical - D59.39
- secondary - D59.39
- specified NEC - D59.39
- secondary - D59.39
- specified NEC - D59.39
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Syndrome
- hemolytic-uremic
- atypical
- Syndrome
- hemolytic-uremic
- atypical
- secondary
- Syndrome
- hemolytic-uremic
- atypical
- specified NEC
- Syndrome
- hemolytic-uremic
- secondary
- Syndrome
- hemolytic-uremic
- specified NEC
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Atypical Hemolytic Uremic Syndrome
an hereditary hemolytic uremic syndrome associated with variations in the gene that encodes complement factor h, or the related proteins cfhr1 and cfhr3. disease often progresses to chronic kidney failure without the prodromal symptoms of enterocolitis and diarrhea that characterize typical hemolytic uremic syndrome.
Patient EducationClinical
Kidney Diseases
You have two kidneys, each about the size of your fist. They are near the middle of your back, just below the rib cage. Inside each kidney there are about a million tiny structures called nephrons. They filter your blood. They remove wastes and extra water, which become urine. The urine flows through tubes called ureters.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Code History & ChangesHistory
Replacement D59.39 replaces the following previously assigned code(s):
- D59.3 - Hemolytic-uremic syndrome
Questions About D59.39Overview
Is D59.39 (Hemolytic-uremic syndrome) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other hemolytic-uremic syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D59.39 group to?
When other hemolytic-uremic syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.
Footnotes
[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.
