2026 ICD-10-CM Diagnosis Code D56.8Other thalassemias
ICD-10-CM Codes›D50–D89›D55-D59›D56
- Billable — Valid for Submission
- Chronic Condition
D56.8 is a billable ICD-10-CM diagnosis code for other thalassemias. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 791, 793, 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.
D56.8 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 48 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 48, ESRD (V21) category 48, and ESRD (V24) category 48 for payment year 2026.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D56.8 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2026 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Alpha-beta thalassemia
- Beta plus thalassemia
- Beta zero thalassemia
- Gamma thalassemia
- Hb Lepore thalassemia
- Hemoglobin C beta plus thalassemia
- Hemoglobin C beta thalassemia
- Hemoglobin C beta zero thalassemia
- Hemoglobin C disease
- Hemoglobin C/beta thalassemia disease
- Hemoglobin Constant Spring trait
- Hemoglobin D beta plus thalassemia
- Hemoglobin D beta zero thalassemia
- Hemoglobin D disease
- Hemoglobin D/beta thalassemia disease
- Hemoglobin H constant spring thalassemia
- Homozygous hemoglobin H constant spring thalassemia
- Thalassemia with other hemoglobinopathy
- Thalassemia-hemoglobin C disease
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Dominant thalassemia
- Hemoglobin C thalassemia
- Mixed thalassemia
- Thalassemia with other hemoglobinopathy
Type 1 Excludes
- hemoglobin C disease D58.2
- hemoglobin E disease D58.2
- other hemoglobinopathies D58.2
- sickle-cell anemia D57
- sickle-cell thalassemia D57.4
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disease, diseased See Also: Syndrome;
Thalassemia (anemia) (disease) D56.9
dominant D56.8
C D56.8
mixed D56.8
specified type NEC D56.8
variants D56.8
Variants, thalassemic D56.8
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Hemoglobin C Disease
a disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. there may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.Hemoglobin C Disease
an autosomal recessive hemoglobinopathy with a mild clinical course. most patients are asymptomatic. when symptoms appear, they include mild hemolytic anemia and occasionally jaundice.Sickle Cell-Hemoglobin C Disease|HbSC|Hemoglobin SC Disease|Hemoglobin SC Disease
a hemoglobinopathy that is considered a hybrid of sickle cell disease and hemoglobin c disease. patients present with the symptoms of sickle cell disease but the latter are less frequent and severe compared to sickle cell disease.Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease|Vaso-Occlusive Crisis in Hemoglobin SC Disease|Vaso-Occlusive Crisis of Hemoglobin SC Disease|Vaso-Occlusive Crisis of Sickle Cell-Hemoglobin C Disease
sickle cell-hemoglobin c disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.
Patient EducationClinical
Thalassemia
Thalassemias are inherited blood disorders. If you have one, your body makes fewer healthy red blood cells and less hemoglobin. Hemoglobin is a protein that carries oxygen to the body. That leads to anemia. Thalassemias occur most often among people of Italian, Greek, Middle Eastern, Southern Asian, and African descent.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D56.8 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D56.8Overview
What is the ICD-10 code for other thalassemias?
The ICD-10-CM code for other thalassemias is D56.8 (sometimes written as D568). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is D56.8 (Thalassemia) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other thalassemias on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D56.8 group to?
When other thalassemias is the principal diagnosis on an inpatient stay, it groups to MS-DRG 791, 793, 811, 812, with relative weights from 0.9182 to 4.1696 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D56.8?
Under the General Equivalence Mappings, other thalassemias converts to ICD-9-CM 282.49 (thalassemia NEC). The mapping is a direct match.
Does D56.8 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. D56.8 mapped to HCC 48 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 48 (Coagulation Defects and Other Specified Hematological Disorders), ESRD (V21) category 48 (Coagulation Defects and Other Specified Hematological Disorders), and ESRD (V24) category 48 (Coagulation Defects and Other Specified Hematological Disorders).
