2026 ICD-10-CM Diagnosis Code D56.8Other thalassemias

ICD-10-CM Codes›D50–D89›D55-D59›D56

ICD-10-CM D56.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D56.8 is a billable ICD-10-CM diagnosis code for other thalassemias. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.

Code Identity

ICD-10-CM Code
D56.8
Billable Status
Yes — Valid for Submission
Code Describes
Other thalassemias
Short Description
Other thalassemias
Same as the full description in the CMS dataset.
Parent Code
D56
Thalassemia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD56Thalassemia
This CodeD56.8Other thalassemias

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Alpha-beta thalassemia
  • Beta plus thalassemia
  • Beta zero thalassemia
  • Gamma thalassemia
  • Hb Lepore thalassemia
  • Hemoglobin C beta plus thalassemia
  • Hemoglobin C beta thalassemia
  • Hemoglobin C beta zero thalassemia
  • Hemoglobin C disease
  • Hemoglobin C/beta thalassemia disease
  • Hemoglobin Constant Spring trait
  • Hemoglobin D beta plus thalassemia
  • Hemoglobin D beta zero thalassemia
  • Hemoglobin D disease
  • Hemoglobin D/beta thalassemia disease
  • Hemoglobin H constant spring thalassemia
  • Homozygous hemoglobin H constant spring thalassemia
  • Thalassemia with other hemoglobinopathy
  • Thalassemia-hemoglobin C disease

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Dominant thalassemia
  • Hemoglobin C thalassemia
  • Mixed thalassemia
  • Thalassemia with other hemoglobinopathy

Type 1 Excludes

  • hemoglobin C disease D58.2
  • hemoglobin E disease D58.2
  • other hemoglobinopathies D58.2
  • sickle-cell anemia D57
  • sickle-cell thalassemia D57.4

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • microcytic (hypochromic)
        • familial
    • Disease, diseased
      • hemoglobin or Hb
        • C (Hb-C)
          • thalassemia
    • Hemoglobinopathy(mixed)
      • with thalassemia
    • Thalassemia(anemia) (disease)
      • with other hemoglobinopathy
    • Thalassemia(anemia) (disease)
      • dominant
    • Thalassemia(anemia) (disease)
      • hemoglobin
        • C
    • Thalassemia(anemia) (disease)
      • mixed
    • Thalassemia(anemia) (disease)
      • specified type NEC
    • Thalassemia(anemia) (disease)
      • variants
    • Variants, thalassemic

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD002
Hemolytic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hemoglobin C Disease

    a disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. there may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.

  • Hemoglobin C Disease

    an autosomal recessive hemoglobinopathy with a mild clinical course. most patients are asymptomatic. when symptoms appear, they include mild hemolytic anemia and occasionally jaundice.

  • Sickle Cell-Hemoglobin C Disease|HbSC|Hemoglobin SC Disease|Hemoglobin SC Disease

    a hemoglobinopathy that is considered a hybrid of sickle cell disease and hemoglobin c disease. patients present with the symptoms of sickle cell disease but the latter are less frequent and severe compared to sickle cell disease.

  • Vaso-Occlusive Crisis in Sickle Cell-Hemoglobin C Disease|Vaso-Occlusive Crisis in Hemoglobin SC Disease|Vaso-Occlusive Crisis of Hemoglobin SC Disease|Vaso-Occlusive Crisis of Sickle Cell-Hemoglobin C Disease

    sickle cell-hemoglobin c disease exacerbated by sudden pain caused by sickled erythrocytes impeding blood flow within a vessel.

Patient EducationClinical

Thalassemia

Thalassemias are inherited blood disorders. If you have one, your body makes fewer healthy red blood cells and less hemoglobin. Hemoglobin is a protein that carries oxygen to the body. That leads to anemia. Thalassemias occur most often among people of Italian, Greek, Middle Eastern, Southern Asian, and African descent.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D56.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
282.49 Thalassemia NEC
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D56.8Overview

Is D56.8 (Thalassemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other thalassemias on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D56.8 group to?

When other thalassemias is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D56.8?

Under the General Equivalence Mappings, other thalassemias converts to ICD-9-CM 282.49 (thalassemia NEC). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.