2027 ICD-10-CM Diagnosis Code A52.10Symptomatic neurosyphilis, unspecified
ICD-10-CM Codes›A00–B99›A50-A64›A52
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
A52.10 is a billable ICD-10-CM diagnosis code for symptomatic neurosyphilis, unspecified. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 56 through 57. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 96 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified CNS infection and poliomyelitis and Sexually transmitted infections (excluding HIV and hepatitis).
Code Identity
Code Classification
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to A52.10: its own notes plus those printed at block A50-A64 and Chapter 1. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- diseases generally recognized as communicable or transmissible
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- human immunodeficiency virus [HIV] disease (B20)
- carrier or suspected carrier of infectious disease (Z22.-)
- certain localized infections - see body system-related chapters
- infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
- infectious and parasitic diseases specific to the perinatal period (P35-P39)
- influenza and other acute respiratory infections (J00-J22)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code to identify resistance to antimicrobial drugs (Z16.-)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name A52.10, its category, or a range that includes it.
Applicable To 1
These notes mention A52.10.
- O98.1 Syphilis complicating pregnancy, childbirth and the puerperium
Excludes1 1
These codes carry an Excludes1 note naming A52.10: they are not reported together with it, unless the two conditions are unrelated.
Excludes2 1
These codes carry an Excludes2 note naming A52.10: its condition is not part of those codes, and both may be reported when the patient has both.
- Block A65-A69 Other spirochetal diseases
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Tabes, tabetic A52.10
conjugal A52.10
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Tertiary Syphilis
a stage of syphilis that occurs fifteen to thirty years after the initial infection; it can include gumma formation and cardiovascular or central nervous system involvement (neurosyphilis).
Patient EducationClinical
Syphilis
Syphilis is a sexually transmitted infection (STI) caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert A52.10 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About A52.10Overview
What is the ICD-10 code for symptomatic neurosyphilis, unspecified?
The ICD-10-CM code for symptomatic neurosyphilis, unspecified is A52.10 (sometimes written as A5210). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is A52.10 (Symptomatic neurosyphilis) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report symptomatic neurosyphilis, unspecified on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does A52.10 group to?
When symptomatic neurosyphilis, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 57, 56, with relative weights from 1.2835 to 2.2649 depending on complications. Higher weights mean higher Medicare reimbursement.
Is A52.10 a CC or MCC?
CMS lists A52.10 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 96 closely related codes in its exclusion list.
Can A52.10 be reported with N34.1?
Not as a rule. The Excludes1 note at block A50-A64, which applies to A52.10, lists "nonspecific and nongonococcal urethritis (N34.1)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
