2027 ICD-10-CM Diagnosis Code A04.3Enterohemorrhagic Escherichia coli infection
ICD-10-CM Codes›A00–B99›A00-A09›A04
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Not Chronic
A04.3 is a billable ICD-10-CM diagnosis code for enterohemorrhagic Escherichia coli infection. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 371 through 373. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 81 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Bacterial infections and Intestinal infection.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acute hemorrhagic colitis caused by Escherichia coli
- Enteritis of small intestine caused by Escherichia coli
- Enteroadherent Escherichia coli gastrointestinal tract infection
- Enterohemorrhagic Escherichia coli colitis
- Enterohemorrhagic Escherichia coli enteritis of intestine
- Enterohemorrhagic Escherichia coli enteritis of small intestine
- Enteropathogenic Escherichia coli colitis
- Enteropathogenic Escherichia coli enteritis of intestine
- Enteropathogenic Escherichia coli gastrointestinal tract infection
- Escherichia coli colitis
- Hemorrhage of colon
- Hemorrhagic colitis
- Hemorrhagic enteritis of intestine
- Infection caused by Shiga toxin producing Escherichia coli
- Verotoxigenic Escherichia coli gastrointestinal tract infection
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to A04.3: its own notes plus those printed at A04 and Chapter 1. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- diseases generally recognized as communicable or transmissible
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- carrier or suspected carrier of infectious disease (Z22.-)
- certain localized infections - see body system-related chapters
- infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium (O98.-)
- infectious and parasitic diseases specific to the perinatal period (P35-P39)
- influenza and other acute respiratory infections (J00-J22)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- code to identify resistance to antimicrobial drugs (Z16.-)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name A04.3, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming A04.3: they are not reported together with it, unless the two conditions are unrelated.
- A05 Other bacterial foodborne intoxications, not elsewhere classified
Excludes2 2
These codes carry an Excludes2 note naming A04.3: its condition is not part of those codes, and both may be reported when the patient has both.
- Block P35-P39 Infections specific to the perinatal period
- P37 Other congenital infectious and parasitic diseases
Code First 1
These codes say to code first a condition named in the note, and A04.3 is one of the conditions named.
- M49 Spondylopathies in diseases classified elsewhere
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
E. coli Infections
E. coli is the name of a type of bacteria that lives in your intestines. Most types of E. coli are harmless. However, some types can make you sick and cause diarrhea. One type causes travelers' diarrhea. The worst type of E. coli causes bloody diarrhea, and can sometimes cause kidney failure and even death.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert A04.3 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About A04.3Overview
What is the ICD-10 code for enterohemorrhagic Escherichia coli infection?
The ICD-10-CM code for enterohemorrhagic Escherichia coli infection is A04.3 (sometimes written as A043). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is A04.3 (Other bacterial intestinal infections) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report enterohemorrhagic Escherichia coli infection on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does A04.3 group to?
When enterohemorrhagic Escherichia coli infection is the principal diagnosis on an inpatient stay, it groups to MS-DRG 372, 371, 373, with relative weights from 0.6945 to 1.7087 depending on complications. Higher weights mean higher Medicare reimbursement.
Is A04.3 a CC or MCC?
CMS lists A04.3 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 81 closely related codes in its exclusion list.
Can A04.3 be reported with a code from A05?
Not as a rule. The Excludes1 note at A04, which applies to A04.3, lists "bacterial foodborne intoxications, NEC (A05.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
