2027 ICD-10-CM Diagnosis Code Z92.850Personal history of Chimeric Antigen Receptor T-cell therapy

ICD-10-CM Codes›Z00–Z99›Z77-Z99›Z92

ICD-10-CM Z92.850
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

Z92.850 is a billable ICD-10-CM diagnosis code for personal history of Chimeric Antigen Receptor T-cell therapy. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 951. The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as history of cellular immunotherapy. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Personal history of malignant neoplasm.

Code Identity

ICD-10-CM Code
Z92.850
Billable Status
Yes — Valid for Submission
Code Describes
Personal history of Chimeric Antigen Receptor T-cell therapy
Short Description
Personal history of Chimeric Antigen Receptor T-cell therapy
Same as the full description in the CMS dataset.
Parent Code
Z92.85
Personal history of cellular therapy

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategoryZ92Personal history of medical treatment
This CodeZ92.850Personal history of Chimeric Antigen Receptor T-cell therapy

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z92.850.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z92.850 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review the other POA exempt codes in Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • History of cellular immunotherapy
  • History of chimeric antigen receptor T-cell immunotherapy

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to Z92.850: its own notes plus those printed at Z92.85, Z92, block Z77-Z99, and Chapter 21. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Personal history of CAR T-cell therapy

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Z92.85 Personal history of cellular therapy applies to 3 codes
  • personal history of immune checkpoint inhibitor therapy (Z92.26)
From Z92 Personal history of medical treatment applies to 19 codes
  • postprocedural states (Z98.-)

Code Also

A second code may be needed to fully describe the condition; the note gives no sequencing direction.

From Block Z77-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status applies to 567 codes
  • any follow-up examination (Z08-Z09)

Notes

General instructions on how these codes are used.

From Chapter 21 (Z00-Z99) Factors influencing health status and contact with health services applies to 1,425 codes
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
  • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
  • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name Z92.850, its category, or a range that includes it.

Excludes2 1

These codes carry an Excludes2 note naming Z92.850: its condition is not part of those codes, and both may be reported when the patient has both.

  • Z87.7 Personal history of (corrected) congenital malformations
    personal history of medical treatment (Z92.-) names Z92.-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC027
Personal history of malignant neoplasm
Default principal diagnosis: inpatient No · outpatient Yes

Code History & ChangesHistory

Replacement Z92.850 replaces the following previously assigned code(s):

  • Z92.89 - Personal history of other medical treatment
FY 2022AddedAdded to the ICD-10-CM code setEffective October 1, 2021.
FY 2023–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About Z92.850Overview

What is the ICD-10 code for personal history of Chimeric Antigen Receptor T-cell therapy?

The ICD-10-CM code for personal history of Chimeric Antigen Receptor T-cell therapy is Z92.850 (sometimes written as Z92850). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is Z92.850 (Personal history of cellular therapy) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report personal history of Chimeric Antigen Receptor T-cell therapy on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does Z92.850 group to?

On inpatient claims, personal history of Chimeric Antigen Receptor T-cell therapy maps to MS-DRG 951 (other Factors Influencing Health Status), which carries a relative weight of 0.5574. Higher weights mean higher Medicare reimbursement.

Can Z92.850 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because personal history of Chimeric Antigen Receptor T-cell therapy describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z92.850 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for personal history of Chimeric Antigen Receptor T-cell therapy on inpatient claims. The code appears in the Persons with potential health hazards related to family and personal history and certain conditions influencing health status (Z77-Z99) range of the CMS exempt list.