2026 ICD-10-CM Diagnosis Code Z92.850Personal history of Chimeric Antigen Receptor T-cell therapy

ICD-10-CM Codes›Z00–Z99›Z77-Z99›Z92

ICD-10-CM Z92.850
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z92.850 is a billable ICD-10-CM diagnosis code for personal history of Chimeric Antigen Receptor T-cell therapy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). The code is not accepted as a principal diagnosis by the Medicare Code Editor and exempt from POA reporting. Coders also document this condition as history of cellular immunotherapy. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Personal history of malignant neoplasm.

Code Identity

ICD-10-CM Code
Z92.850
Billable Status
Yes — Valid for Submission
Code Describes
Personal history of Chimeric Antigen Receptor T-cell therapy
Short Description
Personal history of Chimeric Antigen Receptor T-cell therapy
Same as the full description in the CMS dataset.
Parent Code
Z92.85
Personal history of cellular therapy

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ77-Z99Persons with potential health hazards related to family and personal history and certain conditions influencing health status
CategoryZ92Personal history of medical treatment
This CodeZ92.850Personal history of Chimeric Antigen Receptor T-cell therapy

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z92.850.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Present on Admission (POA)Billing

Z92.850 is exempt from POA reporting on inpatient claims to general acute care hospitals. Review other POA exempt codes.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • History of cellular immunotherapy
  • History of chimeric antigen receptor T-cell immunotherapy

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Personal history of CAR T-cell therapy

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • History
      • personal (of)
        • CAR-T (Chimeric Antigen Receptor T-cell) therapy
    • History
      • personal (of)
        • Chimeric Antigen Receptor T-cell (CAR-T) therapy

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC027
Personal history of malignant neoplasm
Default principal diagnosis: inpatient No · outpatient Yes

Code History & ChangesHistory

Replacement Z92.850 replaces the following previously assigned code(s):

  • Z92.89 - Personal history of other medical treatment
FY 2022AddedAdded to the ICD-10-CM code setEffective October 1, 2021.
FY 2023–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z92.850Overview

Is Z92.850 (Personal history of cellular therapy) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report personal history of Chimeric Antigen Receptor T-cell therapy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Can Z92.850 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because personal history of Chimeric Antigen Receptor T-cell therapy describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

Is Z92.850 exempt from POA reporting?

Yes. CMS lists this code among those exempt from present on admission reporting, so hospitals do not assign a POA indicator for personal history of Chimeric Antigen Receptor T-cell therapy on inpatient claims.