2026 ICD-10-CM Diagnosis Code P25.8Other conditions related to interstitial emphysema originating in the perinatal period

ICD-10-CM Codes›P00–P96›P19-P29›P25

ICD-10-CM P25.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

P25.8 is a billable ICD-10-CM diagnosis code for other conditions related to interstitial emphysema originating in the perinatal period. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 791, 793. As a secondary diagnosis, it counts as a major complication or comorbidity (MCC) and places an inpatient stay in the highest severity level of its MS-DRG family. It does not count, however, when the principal diagnosis is one of 78 closely related codes. Coders also document this condition as emphysema of left lung. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Respiratory perinatal condition.

Code Identity

ICD-10-CM Code
P25.8
Billable Status
Yes — Valid for Submission
Code Describes
Other conditions related to interstitial emphysema originating in the perinatal period
Short Description
Oth cond rel to interstit emphysema origin in perinat period
Parent Code
P25
Interstitial emphysema and related conditions originating in the perinatal period

Code Classification

ChapterP00–P96Certain conditions originating in the perinatal period
SectionP19-P29Respiratory and cardiovascular disorders specific to the perinatal period
CategoryP25Interstitial emphysema and related conditions originating in the perinatal period
This CodeP25.8Other conditions related to interstitial emphysema originating in the perinatal period

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Emphysema of left lung
  • Emphysema of right lung
  • Obstructive emphysema
  • Paraseptal emphysema
  • Pulmonary emphysema

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR PNL006
Respiratory perinatal condition
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Pulmonary Emphysema

    enlargement of air spaces distal to the terminal bronchioles where gas-exchange normally takes place. this is usually due to destruction of the alveolar wall. pulmonary emphysema can be classified by the location and distribution of the lesions.

Patient EducationClinical

Lung Diseases

When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. The cells in your body need oxygen to work and grow. During a normal day, you breathe nearly 25,000 times. People with lung disease have difficulty breathing. Millions of people in the U.S. have lung disease.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert P25.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
770.2 NB interstit emphysema
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About P25.8Overview

Is P25.8 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other conditions related to interstitial emphysema originating in the perinatal period on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does P25.8 group to?

When other conditions related to interstitial emphysema originating in the perinatal period is the principal diagnosis on an inpatient stay, it groups to MS-DRG 791, 793, with relative weights from 4.0590 to 4.1696 depending on complications. Higher weights mean higher Medicare reimbursement.

Is P25.8 a CC or MCC?

CMS lists P25.8 as an MCC (major complication or comorbidity) for FY 2026. Reported as a secondary diagnosis, it places the inpatient stay in the highest-weighted DRG of its severity family. It does not count when the principal diagnosis is one of the 78 closely related codes in its exclusion list.

What is the ICD-9 equivalent of P25.8?

Under the General Equivalence Mappings, other conditions related to interstitial emphysema originating in the perinatal period converts to ICD-9-CM 770.2 (NB interstit emphysema). The mapping is approximate, so confirm the match fits the documentation.