Interstitial emphysema and related conditions originating in the perinatal period (P25) ICD-10-CM
The P25 code range covers interstitial emphysema and related conditions originating in the perinatal period with 6 ICD-10-CM diagnosis codes. 5 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Codes in the P25 Range 6 codes · 5 billable
- P25 Interstitial emphysema and related conditions originating in the perinatal periodNon-billable
- P25.0 Interstitial emphysema originating in the perinatal period
- P25.1 Pneumothorax originating in the perinatal period
- P25.2 Pneumomediastinum originating in the perinatal period
- P25.3 Pneumopericardium originating in the perinatal period
- P25.8 Other conditions related to interstitial emphysema originating in the perinatal period
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the P25 range.
Mediastinal Emphysema
Presence of air in the mediastinal tissues due to leakage of air from the tracheobronchial tree, usually as a result of trauma.
Pericardium
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
Pleural Cavity
Paired but separate cavity within the THORACIC CAVITY. It consists of the space between the parietal and visceral PLEURA and normally contains a capillary layer of serous fluid that lubricates the pleural surfaces.
Pneumopericardium
Presence of air or gas in the space between the heart and the PERICARDIUM. The degree of respiratory distress depends on the amount of trapped air and circulation blocked in the systemic and pulmonary veins.
Pneumothorax
An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.
Pneumothorax, Artificial
Injection of air or a more slowly absorbed gas such as nitrogen, into the PLEURAL CAVITY to collapse the lung.
Pulmonary Emphysema
Enlargement of air spaces distal to the TERMINAL BRONCHIOLES where gas-exchange normally takes place. This is usually due to destruction of the alveolar wall. Pulmonary emphysema can be classified by the location and distribution of the lesions.
Subcutaneous Emphysema
Presence of air or gas in the subcutaneous tissues of the body.
About the P25 Code Range
The ICD-10 code section P25 covers various types of interstitial emphysema and related respiratory conditions that begin in the perinatal period, which is around the time of birth. These codes are used to document specific lung and air leak disorders affecting newborns shortly after delivery.
This section includes codes like P25.0 for interstitial emphysema, sometimes known as congenital lobar emphysema or bronchial atresia with segmental pulmonary emphysema; P25.1 for pneumothorax, also called spontaneous or neonatal pulmonary air leak; and P25.2 for pneumomediastinum, which refers to air leaking into the mediastinal space around the lungs. Additionally, P25.3 describes pneumopericardium originating in the perinatal period, a rare air leak into the pericardial sac. The code P25.8 captures other related emphysema types such as obstructive or paraseptal emphysema affecting newborn lungs. Using these specific codes helps healthcare providers accurately identify conditions like subcutaneous emphysema, neonatal pulmonary air leaks, and congenital emphysema for improved diagnosis and treatment documentation. This makes the ICD-10 code for interstitial emphysema and related neonatal respiratory conditions essential for coding perinatal respiratory complications.
Questions About This Page
How many billable codes are in the P25 range?
Of the 6 codes in this range, 5 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the P25 range classify?
The range classifies interstitial emphysema and related conditions originating in the perinatal period. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
