2026 ICD-10-CM Diagnosis Code M31.11Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]
ICD-10-CM Codes›M00–M99›M30-M36›M31
- Billable — Valid for Submission
- Chronic Condition
M31.11 is a billable ICD-10-CM diagnosis code for hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 545 through 547. Coders also document this condition as thrombotic microangiopathy following transplantation of hematopoietic stem cell. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Complication of transplanted organs or tissue, initial encounter; Systemic lupus erythematosus and connective tissue disorders; and Vasculitis.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Thrombotic microangiopathy following transplantation of hematopoietic stem cell
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Transplant-associated thrombotic microangiopathy TA-TMA
Code First
- if applicable:
- complications of bone marrow transplant T86.0
- complications of stem cell transplant T86.5
Use Additional Code
- code to identify specific organ dysfunction, such as:
- acute kidney failure N17
- acute respiratory distress syndrome J80
- capillary leak syndrome I78.8
- diffuse alveolar hemorrhage R04.89
- encephalopathy metabolic septic G93.41
- fluid overload, unspecified E87.70
- graft versus host disease D89.81
- hemolytic uremic syndrome D59.3
- hepatic failure K72
- hepatic veno-occlusive disease K76.5
- idiopathic interstitial pneumonia J84.11
- sinusoidal obstruction syndrome K76.5
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- HSCT-TMA(hematopoietic stem cell transplantation-associated thrombotic microangiopathy)
- Microangiopathy(peripheral)
- thrombotic
- hematopoietic stem cell transplantation-associated [HSCT-TMA]
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Code History & ChangesHistory
Replacement M31.11 replaces the following previously assigned code(s):
- M31.1 - Thrombotic microangiopathy
Questions About M31.11Overview
Is M31.11 (Thrombotic microangiopathy) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA] on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does M31.11 group to?
When hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA] is the principal diagnosis on an inpatient stay, it groups to MS-DRG 545, 546, 547, with relative weights from 0.8362 to 2.4817 depending on complications. Higher weights mean higher Medicare reimbursement.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
