Other systemic involvement of connective tissue (M35) ICD-10-CM
The M35 code range covers other systemic involvement of connective tissue with 26 ICD-10-CM diagnosis codes. 23 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- reactive perforating collagenosis L87.1
Codes in the M35 Range 26 codes · 23 billable
- M35 Other systemic involvement of connective tissueNon-billable
- M35.0 Sjogren syndromeNon-billable
- M35.00 Sjogren syndrome, unspecified
- M35.01 Sjogren syndrome with keratoconjunctivitis
- M35.02 Sjogren syndrome with lung involvement
- M35.03 Sjogren syndrome with myopathy
- M35.04 Sjogren syndrome with tubulo-interstitial nephropathy
- M35.05 Sjogren syndrome with inflammatory arthritis
- M35.06 Sjogren syndrome with peripheral nervous system involvement
- M35.07 Sjogren syndrome with central nervous system involvement
- M35.08 Sjogren syndrome with gastrointestinal involvement
- M35.09 Sjogren syndrome with other organ involvement
- M35.0A Sjogren syndrome with glomerular disease
- M35.0B Sjogren syndrome with vasculitis
- M35.0C Sjogren syndrome with dental involvement
- M35.1 Other overlap syndromes
- M35.2 Behcet's disease
- M35.3 Polymyalgia rheumatica
- M35.4 Diffuse (eosinophilic) fasciitis
- M35.5 Multifocal fibrosclerosis
- M35.6 Relapsing panniculitis [Weber-Christian]
- M35.7 Hypermobility syndrome
- M35.8 Other specified systemic involvement of connective tissueNon-billable
- M35.81 Multisystem inflammatory syndrome
- M35.89 Other specified systemic involvement of connective tissue
- M35.9 Systemic involvement of connective tissue, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the M35 range.
Behcet Syndrome
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Eosinophilia-Myalgia Syndrome
A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
Multifocal Fibrosclerosis
A rare syndrome of unknown etiology characterized by progressive fibrosis involving multiple organ sites.
Panniculitis, Nodular Nonsuppurative
A form of panniculitis characterized by recurrent episodes of fever accompanied by the eruption of single or multiple erythematous subcutaneous nodules on the lower extremities. They normally resolve, but tend to leave depressions in the skin. The condition is most often seen in women, alone or in association with other disorders.
Polymyalgia Rheumatica
A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
Sjogren's Syndrome
Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
About the M35 Code Range
These conditions involve connective tissue across the body. The category includes named disorders as well as other specified and unspecified systemic involvement.
M35.0 groups Sjogren syndrome codes by the organ or body system involved, with a code for unspecified involvement. Other subdivisions name overlap syndromes, Behcet's disease, polymyalgia rheumatica, fasciitis, fibrosclerosis, panniculitis and hypermobility syndrome.
M35.8 contains other specified systemic involvement, including multisystem inflammatory syndrome. M35.9 identifies unspecified systemic involvement of connective tissue.
Questions About This Page
How many billable codes are in the M35 range?
Of the 26 codes in this range, 23 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the M35 range classify?
The range classifies other systemic involvement of connective tissue. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
