2026 ICD-10-CM Diagnosis Code D72.12Drug rash with eosinophilia and systemic symptoms syndrome

ICD-10-CM Codes›D50–D89›D70-D77›D72

ICD-10-CM D72.12
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D72.12 is a billable ICD-10-CM diagnosis code for drug rash with eosinophilia and systemic symptoms syndrome. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 814 through 816. Coders also document this condition as adverse reaction to bone resorption inhibitor. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.

Code Identity

ICD-10-CM Code
D72.12
Billable Status
Yes — Valid for Submission
Code Describes
Drug rash with eosinophilia and systemic symptoms syndrome
Short Description
Drug rash with eosinophilia and systemic symptoms syndrome
Same as the full description in the CMS dataset.
Parent Code
D72.1
Eosinophilia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD72Other disorders of white blood cells
This CodeD72.12Drug rash with eosinophilia and systemic symptoms syndrome

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adverse reaction to bone resorption inhibitor
  • Drug reaction with eosinophilia and systemic symptoms
  • Drug reaction with eosinophilia and systemic symptoms caused by strontium ranelate

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • DRESS syndrome

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Syndrome
      • DRESS (drug rash with eosinophilia and systemic symptoms)
    • Syndrome
      • drug rash with eosinophilia and systemic symptoms (DRESS)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD007
Diseases of white blood cells
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Eosinophilia

    abnormal increase of eosinophils in the blood, tissues or organs.

  • Eosinophilia-Myalgia Syndrome

    a complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. diagnostic features generally include eosinophilia, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (from spitzer et al., j rheumatol suppl 1996 oct;46:73-9; blackburn wd, semin arthritis rheum 1997 jun;26(6):788-93)

  • Pulmonary Eosinophilia

    a condition characterized by infiltration of the lung with eosinophils due to inflammation or other disease processes. major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.

  • Eosinophils

    granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement D72.12 replaces the following previously assigned code(s):

  • D72.1 - Eosinophilia
FY 2021AddedAdded to the ICD-10-CM code setEffective October 1, 2020.
FY 2022–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D72.12Overview

Is D72.12 (Eosinophilia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report drug rash with eosinophilia and systemic symptoms syndrome on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D72.12 group to?

When drug rash with eosinophilia and systemic symptoms syndrome is the principal diagnosis on an inpatient stay, it groups to MS-DRG 814, 815, 816, with relative weights from 0.6320 to 2.1267 depending on complications. Higher weights mean higher Medicare reimbursement.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.