2026 ICD-10-CM Diagnosis Code D58.0Hereditary spherocytosis

ICD-10-CM Codes›D50–D89›D55-D59›D58

ICD-10-CM D58.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D58.0 is a billable ICD-10-CM diagnosis code for hereditary spherocytosis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Hemolytic anemia.

Code Identity

ICD-10-CM Code
D58.0
Billable Status
Yes — Valid for Submission
Code Describes
Hereditary spherocytosis
Short Description
Hereditary spherocytosis
Same as the full description in the CMS dataset.
Parent Code
D58
Other hereditary hemolytic anemias

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD58Other hereditary hemolytic anemias
This CodeD58.0Hereditary spherocytosis

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Hereditary spherocytosis
  • Hereditary spherocytosis due to beta spectrin defect
  • Hereditary spherocytosis due to combined deficiency of spectrin AND ankyrin
  • Hereditary spherocytosis due to deficiency of protein 4.2
  • Hereditary spherocytosis due to spectrin deficiency
  • Mild hereditary spherocytosis due to combined deficiency of spectrin AND ankyrin
  • Mild hereditary spherocytosis due to spectrin deficiency
  • Severe hereditary spherocytosis due to combined deficiency of spectrin AND ankyrin
  • Severe hereditary spherocytosis due to spectrin deficiency
  • Spherocytosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Acholuric (familial) jaundice
  • Congenital (spherocytic) hemolytic icterus
  • Minkowski-Chauffard syndrome

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • congenital
        • spherocytic
    • Disease, diseased
      • hemoglobin or Hb
        • spherocytosis
    • Jaundice(yellow)
      • newborn
        • spherocytosis (congenital)
    • Spherocytosis(congenital) (familial) (hereditary)
    • Spherocytosis(congenital) (familial) (hereditary)
      • hemoglobin disease
    • Syndrome
      • Minkowski-Chauffard

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD002
Hemolytic anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hereditary Spherocytosis

    an autosomal dominant inherited disorder characterized by the presence of smaller than normal, sphere-shaped erythrocytes. it results in hemolytic anemia and splenomegaly.

  • Spherocytosis

    a hereditary or acquired blood disorder characterized by the presence of smaller than normal, sphere-shaped erythrocytes. it results in hemolytic anemia and splenomegaly.

Patient EducationClinical

Anemia

If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D58.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
282.0 Hereditary spherocytosis
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D58.0Overview

Is D58.0 (Other hereditary hemolytic anemias) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hereditary spherocytosis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D58.0 group to?

When hereditary spherocytosis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D58.0?

Under the General Equivalence Mappings, hereditary spherocytosis converts to ICD-9-CM 282.0 (hereditary spherocytosis). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.