2026 ICD-10-CM Diagnosis Code D57.40Sickle-cell thalassemia without crisis

ICD-10-CM Codes›D50–D89›D55-D59›D57

ICD-10-CM D57.40
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D57.40 is a billable ICD-10-CM diagnosis code for sickle-cell thalassemia without crisis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. Coders also document this condition as beta zero thalassemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Sickle cell trait/anemia.

Code Identity

ICD-10-CM Code
D57.40
Billable Status
Yes — Valid for Submission
Code Describes
Sickle-cell thalassemia without crisis
Short Description
Sickle-cell thalassemia without crisis
Same as the full description in the CMS dataset.
Parent Code
D57.4
Sickle-cell thalassemia

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD55-D59Hemolytic anemias
CategoryD57Sickle-cell disorders
This CodeD57.40Sickle-cell thalassemia without crisis

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Beta zero thalassemia
  • Heterozygous hemoglobinopathy
  • Sickle cell trait
  • Sickle cell trait with coexistent alpha-thalassemia
  • Sickle cell-beta^0^-thalassemia
  • Sickle cell-beta-thalassemia
  • Sickle cell-hemoglobin Lepore disease
  • Sickle cell-thalassemia disease
  • Sickle cell-thalassemia disease without crisis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Microdrepanocytosis
  • Sickle-cell thalassemia NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Anemia(essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
      • microdrepanocytosis
    • Disease, diseased
      • sickle-cell
        • thalassemia
    • Disease, diseased
      • sickle-cell
        • thalassemia
          • without crisis
    • Hemoglobinopathy(mixed)
      • sickle-cell
        • with thalassemia
    • Hemoglobinopathy(mixed)
      • sickle-cell
        • with thalassemia
          • without crisis
    • Microdrepanocytosis

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD005
Sickle cell trait/anemia
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Sickle Cell Trait

    the condition of being heterozygous for hemoglobin s.

  • Sickle Cell Trait

    an individual who is heterozygous for the mutation that causes sickle cell anemia.

Patient EducationClinical

Sickle Cell Disease

Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells.

The full article covers:

  • What is sickle cell disease (SCD)?
  • What causes sickle cell disease (SCD)?
  • Who is more likely to have sickle cell disease (SCD)?
  • What are the symptoms of sickle cell disease (SCD)?
  • How is sickle cell disease (SCD) diagnosed?
  • What are the treatments for sickle cell disease (SCD)?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D57.40 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
282.41 Thlasema Hb-S w/o crisis
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D57.40Overview

Is D57.40 (Sickle-cell thalassemia) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report sickle-cell thalassemia without crisis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D57.40 group to?

When sickle-cell thalassemia without crisis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D57.40?

Under the General Equivalence Mappings, sickle-cell thalassemia without crisis converts to ICD-9-CM 282.41 (thlasema Hb-S w/o crisis). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.