2026 ICD-10-CM Diagnosis Code D53.0Protein deficiency anemia
ICD-10-CM Codes›D50–D89›D50-D53›D53
- Billable — Valid for Submission
- Chronic Condition
D53.0 is a billable ICD-10-CM diagnosis code for protein deficiency anemia. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 811 through 812. Coders also document this condition as anemia due to protein deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Nutritional anemia.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Anemia due to protein deficiency
- Non megaloblastic anemia associated with nutritional deficiency
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Amino-acid deficiency anemia
- Orotaciduric anemia
Type 1 Excludes
- Lesch-Nyhan syndrome E79.1
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
anemia D53.0
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
amino-acid-deficiency D53.0
amino-acid D53.0
protein D53.0
amino-acid D53.0
protein D53.0
orotic aciduria D53.0
protein-deficiency D53.0
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Anemia
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D53.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D53.0Overview
What is the ICD-10 code for protein deficiency anemia?
The ICD-10-CM code for protein deficiency anemia is D53.0 (sometimes written as D530). It is billable on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
Is D53.0 (Other nutritional anemias) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report protein deficiency anemia on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does D53.0 group to?
When protein deficiency anemia is the principal diagnosis on an inpatient stay, it groups to MS-DRG 811, 812, with relative weights from 0.9182 to 1.4043 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D53.0?
Under the General Equivalence Mappings, protein deficiency anemia converts to ICD-9-CM 281.4 (protein defic anemia). The mapping is a direct match.
