2027 ICD-10-CM Diagnosis Code D49.1Neoplasm of unspecified behavior of respiratory system
ICD-10-CM Codes›C00–D49›D49›D49
- Billable — Valid for Submission
- Not Chronic
ICD-10-CM D49.1
D49.1 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of respiratory system. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 180 through 182. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.
Code Identity
ICD-10-CM Code
D49.1
Billable Status
Yes — Valid for Submission
Code Describes
Neoplasm of unspecified behavior of respiratory system
Short Description
Neoplasm of unspecified behavior of respiratory system
Same as the full description in the CMS dataset.
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Hilar mass
- Left lung neoplasm
- Mass of petrous part of temporal bone
- Neoplasm of accessory sinus
- Neoplasm of anterior commissure
- Neoplasm of arytenoid cartilage
- Neoplasm of bronchus
- Neoplasm of bronchus of left lower lobe
- Neoplasm of bronchus of left upper lobe
- Neoplasm of bronchus of middle lobe of right lung
- Neoplasm of bronchus of right lower lobe
- Neoplasm of bronchus of right upper lobe
- Neoplasm of carina
- Neoplasm of cartilage of nose
- Neoplasm of epiglottis
- Neoplasm of ethmoidal sinus
- Neoplasm of eustachian tube
- Neoplasm of false vocal cord
- Neoplasm of frontal sinus
- Neoplasm of glottis
- Neoplasm of hilus of lung
- Neoplasm of inferior nasal turbinate
- Neoplasm of infrahyoid epiglottis
- Neoplasm of laryngeal aspect of aryepiglottic fold
- Neoplasm of laryngeal aspect of interarytenoid fold
- Neoplasm of laryngeal cartilage
- Neoplasm of laryngeal commissure
- Neoplasm of laryngeal surface of epiglottis
- Neoplasm of larynx
- Neoplasm of left lower lobe of lung
- Neoplasm of left upper lobe of lung
- Neoplasm of lower respiratory tract
- Neoplasm of lower respiratory tract and mediastinum
- Neoplasm of lung
- Neoplasm of lung parenchyma
- Neoplasm of main bronchus
- Neoplasm of mastoid air cells
- Neoplasm of mastoid antrum
- Neoplasm of maxillary sinus
- Neoplasm of mesothelial tissue of pleura
- Neoplasm of middle ear
- Neoplasm of middle ear and mastoid
- Neoplasm of middle lobe of right lung
- Neoplasm of nasal cavity
- Neoplasm of nasal cavity and nasopharynx
- Neoplasm of nasal concha
- Neoplasm of nasal vestibule
- Neoplasm of ostium of eustachian tube
- Neoplasm of parietal pleura
- Neoplasm of pleura
- Neoplasm of respiratory tract
- Neoplasm of right lower lobe of lung
- Neoplasm of right upper lobe of lung
- Neoplasm of septum of nose
- Neoplasm of sphenoidal sinus
- Neoplasm of subglottis
- Neoplasm of supraglottis
- Neoplasm of suprahyoid epiglottis
- Neoplasm of trachea
- Neoplasm of tympanic cavity
- Neoplasm of upper respiratory tract
- Neoplasm of ventricle of larynx
- Neoplasm of visceral pleura
- Neoplasm of vocal cord
- Neoplasm of Waldeyer's ring
- Posterior commissure neoplasm
- Pulmonary neoplasm embolism
- Right lung neoplasm
- Transglottic neoplasm
- Tumor embolus
- Tumor of respiratory system
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D49.1: its own notes plus those printed at D49 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- 'growth' NOS
- neoplasm NOS
- new growth NOS
- tumor NOS
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Notes
General instructions on how these codes are used.
- Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
- Functional activity
- All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
- Morphology [Histology]
- Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
- Primary malignant neoplasms overlapping site boundaries
- A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
- Malignant neoplasm of ectopic tissue
- Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D49.1, its category, or a range that includes it.
Excludes1 3
These codes carry an Excludes1 note naming D49.1: they are not reported together with it, unless the two conditions are unrelated.
- D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skinneoplasm of unspecified behavior of cartilage of larynx (D49.1)
- D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skinneoplasm of unspecified behavior of cartilage of nose (D49.1)
- Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromesneoplasms of unspecified behavior (D49.-) names D49.-, which includes this code
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
CCSR NEO072
Neoplasms of unspecified nature or uncertain behavior
Default principal diagnosis: inpatient Yes · outpatient Yes
Table of NeoplasmsClinical
Anatomical sites in the Table of Neoplasms that reference this code family.
| Site | Malig. Primary | Malig. Secondary | Ca in situ | Benign | Uncertain | Unspec. |
|---|---|---|---|---|---|---|
| antrum (Highmore) (maxillary) | C31.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| antrum (Highmore) (maxillary) › tympanicum | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| aryepiglottic fold › laryngeal aspect | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| arytenoid (cartilage) | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| auditory › canal (external) (skin) › internal | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| auditory › tube | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| bronchiogenic, bronchogenic (lung) | C34.9 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| bronchiole | C34.9 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| bronchus | C34.9 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| bronchus › carina | C34.0 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| bronchus › lower lobe of lung | C34.3 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| bronchus › main | C34.0 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| bronchus › middle lobe of lung | C34.2 | C78.0 | D02.21 | D14.31 | D38.1 | D49.1 |
| bronchus › upper lobe of lung | C34.1 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| carina (bronchus) | C34.0 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › arytenoid | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › bronchi | C34.0 | C78.39 | – | D14.3 | D38.1 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › cricoid | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › cuneiform | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › epiglottis | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › larynx, laryngeal | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › nose, nasal | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › thyroid | C32.3 | C78.39 | D02.0 | D14.1 | D38.0 | D49.1 |
| cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › trachea | C33 | C78.39 | D02.1 | D14.2 | D38.1 | D49.1 |
| cavity › nasal | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| cavity › tympanic | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| commissure › laryngeal | C32.0 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| concha [See Also: Neoplasm, skin, ear] › nose | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| cord (true) (vocal) | C32.0 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| cord (true) (vocal) › false | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| cricoid › cartilage | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| cuneiform cartilage | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| ear (external) [See Also: Neoplasm, skin, ear] › inner | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| ear (external) [See Also: Neoplasm, skin, ear] › middle | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| epiglottis | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| epiglottis › cartilage | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| epiglottis › posterior (laryngeal) surface | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| epiglottis › suprahyoid portion | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| ethmoid (sinus) | C31.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| eustachian tube | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| frontal › sinus | C31.2 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| glottis | C32.0 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| hilus of lung | C34.0 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| interarytenoid fold › laryngeal aspect | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| larynx, laryngeal NEC | C32.9 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| larynx, laryngeal NEC › aryepiglottic fold | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| larynx, laryngeal NEC › cartilage (arytenoid) (cricoid) (cuneiform) (thyroid) | C32.3 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| larynx, laryngeal NEC › commissure (anterior) (posterior) | C32.0 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| larynx, laryngeal NEC › extrinsic NEC | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| larynx, laryngeal NEC › interarytenoid fold | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| larynx, laryngeal NEC › intrinsic | C32.0 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| larynx, laryngeal NEC › ventricular band | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| lingula, lung | C34.1 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung | C34.9 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung › azygos lobe | C34.1 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung › carina | C34.0 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung › hilus | C34.0 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung › lingula | C34.1 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung › lobe NEC | C34.9 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung › lower lobe | C34.3 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung › main bronchus | C34.0 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| lung › middle lobe | C34.2 | C78.0 | D02.21 | D14.31 | D38.1 | D49.1 |
| lung › upper lobe | C34.1 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| mastoid (air cells) (antrum) (cavity) | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| maxilla, maxillary (superior) › antrum | C31.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| maxilla, maxillary (superior) › sinus | C31.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| mucosa › nasal | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nares, naris (anterior) (posterior) | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nose, nasal › cartilage | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nose, nasal › cavity | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nose, nasal › fossa | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nose, nasal › internal | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nose, nasal › mucosa | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nose, nasal › septum | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nose, nasal › turbinate (mucosa) | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nose, nasal › vestibule | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| nostril | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| pleura, pleural (cavity) | C38.4 | C78.2 | – | D19.0 | D38.2 | D49.1 |
| pleura, pleural (cavity) › parietal | C38.4 | C78.2 | – | D19.0 | D38.2 | D49.1 |
| pleura, pleural (cavity) › visceral | C38.4 | C78.2 | – | D19.0 | D38.2 | D49.1 |
| pulmonary [See Also: Neoplasm, lung] | C34.9 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| respiratory › organs or system NEC | C39.9 | C78.30 | D02.4 | D14.4 | D38.6 | D49.1 |
| respiratory › tract NEC | C39.9 | C78.30 | D02.4 | D14.4 | D38.5 | D49.1 |
| respiratory › tract NEC › upper | C39.0 | C78.30 | D02.4 | D14.4 | D38.5 | D49.1 |
| septum › nasal | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| sinus (accessory) | C31.9 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| sinus (accessory) › ethmoidal | C31.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| sinus (accessory) › frontal | C31.2 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| sinus (accessory) › maxillary | C31.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| sinus (accessory) › nasal, paranasal NEC | C31.9 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| sinus (accessory) › sphenoid | C31.3 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| sphenoid | C31.3 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| sphenoid › sinus | C31.3 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| subglottis, subglottic | C32.2 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| subpleural | C34.9 | C78.0 | D02.2 | D14.3 | D38.1 | D49.1 |
| supraglottis | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| thyroid (gland) › cartilage | C32.3 | C78.39 | D02.0 | D14.1 | D38.0 | D49.1 |
| trachea (cartilage) (mucosa) | C33 | C78.39 | D02.1 | D14.2 | D38.1 | D49.1 |
| tracheobronchial | C34.8 | C78.39 | D02.1 | D14.2 | D38.1 | D49.1 |
| turbinate (bone) › nasal | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| tympanic cavity | C30.1 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| ventricular band of larynx | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| vestibule › nose | C30.0 | C78.39 | D02.3 | D14.0 | D38.5 | D49.1 |
| vocal cords (true) | C32.0 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| vocal cords (true) › false | C32.1 | C78.31 | D02.0 | D14.1 | D38.0 | D49.1 |
| windpipe | C33 | C78.39 | D02.1 | D14.2 | D38.1 | D49.1 |
Patient EducationClinical
Lung Diseases
When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. The cells in your body need oxygen to work and grow. During a normal day, you breathe nearly 25,000 times. People with lung disease have difficulty breathing. Millions of people in the U.S. have lung disease.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D49.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.
Questions About D49.1Overview
What is the ICD-10 code for neoplasm of unspecified behavior of respiratory system?
The ICD-10-CM code for neoplasm of unspecified behavior of respiratory system is D49.1 (sometimes written as D491). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D49.1 (Neoplasms of unspecified behavior) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of respiratory system on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D49.1 group to?
When neoplasm of unspecified behavior of respiratory system is the principal diagnosis on an inpatient stay, it groups to MS-DRG 181, 180, 182, with relative weights from 0.7436 to 1.7800 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of D49.1?
Under the General Equivalence Mappings, neoplasm of unspecified behavior of respiratory system converts to ICD-9-CM 239.1 (respiratory neoplasm NOS). The mapping is a direct match.
