2026 ICD-10-CM Diagnosis Code Z16.341Resistance to single antimycobacterial drug

ICD-10-CM Codes›Z00–Z99›Z16›Z16

ICD-10-CM Z16.341
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

Z16.341 is a billable ICD-10-CM diagnosis code for resistance to single antimycobacterial drug. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 867 through 869. The code is not accepted as a principal diagnosis by the Medicare Code Editor. Coders also document this condition as antibiotic resistant tuberculosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Resistance to antimicrobial drugs.

Code Identity

ICD-10-CM Code
Z16.341
Billable Status
Yes — Valid for Submission
Code Describes
Resistance to single antimycobacterial drug
Short Description
Resistance to single antimycobacterial drug
Same as the full description in the CMS dataset.
Parent Code
Z16.34
Resistance to antimycobacterial drug(s)

Code Classification

ChapterZ00–Z99Factors influencing health status and contact with health services
SectionZ16Resistance to antimicrobial drugs
CategoryZ16Resistance to antimicrobial drugs
This CodeZ16.341Resistance to single antimycobacterial drug

Code EditsBilling

Medicare Code Editor checks that affect claim validity for Z16.341.

Unacceptable principal diagnosis
There are selected codes that describe a circumstance which influences an individual's health status but not a current illness or injury, or codes that are not specific manifestations but may be due to an underlying cause. These codes are considered unacceptable as a principal diagnosis.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Antibiotic resistant tuberculosis
  • Dapsone resistant leprosy
  • Ethambutol resistant tuberculosis
  • Ethionamide resistant tuberculosis
  • Isoniazid resistant tuberculosis
  • Pyrazinamide resistant tuberculosis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Resistance to antimycobacterial drug NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Resistance, resistant(to)
      • organism (s)
        • to
          • drug
            • antimycobacterial (single)
    • Resistance, resistant(to)
      • organism (s)
        • to
          • drug
            • tuberculostatics (single)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR FAC015
Resistance to antimicrobial drugs
Default principal diagnosis: inpatient No · outpatient Yes

Convert Z16.341 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
V09.70 Inf mcr rst oth ag nt ml
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About Z16.341Overview

Is Z16.341 (Resistance to antimycobacterial drug(s)) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report resistance to single antimycobacterial drug on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does Z16.341 group to?

On inpatient claims, resistance to single antimycobacterial drug maps to MS-DRG 867, 868, 869, with relative weights from 0.7297 to 2.0932 depending on complications. Higher weights mean higher Medicare reimbursement.

Can Z16.341 be a principal diagnosis?

No. The Medicare Code Editor rejects this code as a principal diagnosis because resistance to single antimycobacterial drug describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.

What is the ICD-9 equivalent of Z16.341?

Under the General Equivalence Mappings, resistance to single antimycobacterial drug converts to ICD-9-CM V09.70 (inf mcr rst oth ag nt ml). The mapping is a direct match.