2026 ICD-10-CM Diagnosis Code Z17Estrogen, and other hormones and factors receptor status
Z17 is a non-billable ICD-10-CM category code for estrogen, and other hormones and factors receptor status, so it cannot be submitted on claims. Use a more specific code from this category instead, such as Z17.0, Z17.1, Z17.21, and Z17.22.
Code Identity
Code Classification
Specific Coding for Estrogen, and other hormones and factors receptor statusOverview
Non-specific codes like Z17 require more characters. Use one of these billable codes instead:
Use Z17.0 for Estrogen receptor positive status [ER+]
Use Z17.1 for Estrogen receptor negative status [ER-]
Z17.2 for Progesterone receptor status
Use Z17.21 for Progesterone receptor positive status
Use Z17.22 for Progesterone receptor negative status
Z17.3 for Human epidermal growth factor 2 receptor
Use Z17.31 for Human epidermal growth factor receptor 2 positive status
Use Z17.32 for Human epidermal growth factor receptor 2 negative status
Z17.4 for Combined receptor status
Z17.41 for Hormone receptor positive
Z17.42 for Hormone receptor negative
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
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Code HistoryHistory
Questions About Z17Overview
Is Z17 (Estrogen, and other hormones and factors receptor status) a billable code?
No. This is a category header that groups the codes for estrogen, and other hormones and factors receptor status, and headers cannot be submitted on claims. Claims for estrogen, and other hormones and factors receptor status need a more specific code from this category, such as Z17.0, Z17.1, and Z17.21.
