2027 ICD-10-CM Diagnosis Code R85.81Anal high risk human papillomavirus (HPV) DNA test positive

ICD-10-CM Codes›R00–R99›R83-R89›R85

ICD-10-CM R85.81
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

R85.81 is a billable ICD-10-CM diagnosis code for anal high risk human papillomavirus (HPV) DNA test positive. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 393 through 395. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as high risk human papillomavirus deoxyribonucleic acid detected. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Abnormal findings without diagnosis.

Code Identity

ICD-10-CM Code
R85.81
Billable Status
Yes — Valid for Submission
Code Describes
Anal high risk human papillomavirus (HPV) DNA test positive
Short Description
Anal high risk human papillomavirus (HPV) DNA test positive
Same as the full description in the CMS dataset.
Parent Code
R85.8
Other abnormal findings in specimens from digestive organs and abdominal cavity

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR83-R89Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
CategoryR85Abnormal findings in specimens from digestive organs and abdominal cavity
This CodeR85.81Anal high risk human papillomavirus (HPV) DNA test positive

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • High risk human papillomavirus deoxyribonucleic acid detected
  • High risk human papillomavirus detected
  • Human papillomavirus deoxyribonucleic acid detected, high risk on anal specimen

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to R85.81: its own notes plus those printed at R85, block R83-R89, and Chapter 18. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From R85 Abnormal findings in specimens from digestive organs and abdominal cavity applies to 21 codes
  • abnormal findings in peritoneal fluid
  • abnormal findings in saliva

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On R85.81 itself
  • anogenital warts due to human papillomavirus (HPV) (A63.0)
  • condyloma acuminatum (A63.0)
From R85 Abnormal findings in specimens from digestive organs and abdominal cavity applies to 21 codes
  • cloudy peritoneal dialysis effluent (R88.0)
  • fecal abnormalities (R19.5)
From Block R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis applies to 93 codes
  • abnormal findings on antenatal screening of mother (O28.-)
  • diagnostic abnormal findings classified elsewhere - see Alphabetical Index

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis applies to 93 codes
  • abnormal findings on examination of blood, without diagnosis (R70-R79)
  • abnormal findings on examination of urine, without diagnosis (R80-R82)
  • abnormal tumor markers (R97.-)
From Chapter 18 (R00-R99) Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified applies to 774 codes
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)

Notes

General instructions on how these codes are used.

From Chapter 18 (R00-R99) Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified applies to 774 codes
  • This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
  • Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
  • The conditions and signs or symptoms included in categories R00-R94 consist of:
  • (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
  • (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
  • (c) provisional diagnosis in a patient who failed to return for further investigation or care;
  • (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
  • (e) cases in which a more precise diagnosis was not available for any other reason;
  • (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name R85.81, its category, or a range that includes it.

Excludes2 1

These codes carry an Excludes2 note naming R85.81: its condition is not part of those codes, and both may be reported when the patient has both.

  • R85.61 Abnormal cytologic smear of anus
    anal high risk human papillomavirus (HPV) DNA test positive (R85.81)

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM017
Abnormal findings without diagnosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

HPV

Human papillomavirus (HPV) is a group of more than 200 related viruses. Some of them are spread through sexual contact. Most people have been exposed to HPV. Usually, your immune system controls HPV infections, and they go away on their own and don't cause any health problems, but some need treatment.

The full article covers:

  • What is HPV?
  • Who is at risk for HPV infections?
  • What are the symptoms of HPV infections?
  • How are HPV infections diagnosed?
  • What are the treatments for HPV infections?
  • Can HPV infections be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R85.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
796.75 Anal hi risk HPV-DNA pos
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About R85.81Overview

What is the ICD-10 code for anal high risk human papillomavirus (HPV) DNA test positive?

The ICD-10-CM code for anal high risk human papillomavirus (HPV) DNA test positive is R85.81 (sometimes written as R8581). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is R85.81 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report anal high risk human papillomavirus (HPV) DNA test positive on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does R85.81 group to?

When anal high risk human papillomavirus (HPV) DNA test positive is the principal diagnosis on an inpatient stay, it groups to MS-DRG 394, 395, 393, with relative weights from 0.6379 to 1.5877 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R85.81 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the anal high risk human papillomavirus (HPV) DNA test positive is established, that condition takes the principal position instead.

Can R85.81 be reported with A63.0?

Not as a rule. The Excludes1 note on R85.81 lists "anogenital warts due to human papillomavirus (HPV) (A63.0)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).