2026 ICD-10-CM Diagnosis Code R85.81Anal high risk human papillomavirus (HPV) DNA test positive

ICD-10-CM Codes›R00–R99›R83-R89›R85

ICD-10-CM R85.81
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R85.81 is a billable ICD-10-CM diagnosis code for anal high risk human papillomavirus (HPV) DNA test positive. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 393 through 395. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as high risk human papillomavirus deoxyribonucleic acid detected. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Abnormal findings without diagnosis.

Code Identity

ICD-10-CM Code
R85.81
Billable Status
Yes — Valid for Submission
Code Describes
Anal high risk human papillomavirus (HPV) DNA test positive
Short Description
Anal high risk human papillomavirus (HPV) DNA test positive
Same as the full description in the CMS dataset.
Parent Code
R85.8
Other abnormal findings in specimens from digestive organs and abdominal cavity

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR83-R89Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
CategoryR85Abnormal findings in specimens from digestive organs and abdominal cavity
This CodeR85.81Anal high risk human papillomavirus (HPV) DNA test positive

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • High risk human papillomavirus deoxyribonucleic acid detected
  • High risk human papillomavirus detected
  • Human papillomavirus deoxyribonucleic acid detected
  • Human papillomavirus deoxyribonucleic acid detected, high risk on anal specimen

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • anogenital warts due to human papillomavirus HPV A63.0
  • condyloma acuminatum A63.0

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Abnormal, abnormality, abnormalities
      • cytology
        • anus
          • human papillomavirus (HPV) DNA test
            • high risk positive
    • Abnormal, abnormality, abnormalities
      • Papanicolaou (smear)
        • anus
          • human papillomavirus (HPV) DNA test
            • high risk positive

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM017
Abnormal findings without diagnosis
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

HPV

Human papillomavirus (HPV) is a group of more than 200 related viruses. Some of them are spread through sexual contact. Most people have been exposed to HPV. Usually, your immune system controls HPV infections, and they go away on their own and don't cause any health problems, but some need treatment.

The full article covers:

  • What is HPV?
  • Who is at risk for HPV infections?
  • What are the symptoms of HPV infections?
  • How are HPV infections diagnosed?
  • What are the treatments for HPV infections?
  • Can HPV infections be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R85.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
796.75 Anal hi risk HPV-DNA pos
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R85.81Overview

Is R85.81 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report anal high risk human papillomavirus (HPV) DNA test positive on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R85.81 group to?

When anal high risk human papillomavirus (HPV) DNA test positive is the principal diagnosis on an inpatient stay, it groups to MS-DRG 393, 394, 395, with relative weights from 0.6490 to 1.5993 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R85.81 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the anal high risk human papillomavirus (HPV) DNA test positive is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R85.81?

Under the General Equivalence Mappings, anal high risk human papillomavirus (HPV) DNA test positive converts to ICD-9-CM 796.75 (anal hi risk HPV-DNA pos). The mapping is a direct match.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.