2026 ICD-10-CM Diagnosis Code R97Abnormal tumor markers

ICD-10-CM Codes›R00–R99›R97›R97

ICD-10-CM R97
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R97 is a non-billable ICD-10-CM category code for abnormal tumor markers, so it cannot be submitted on claims. Use a more specific code from this category instead, such as R97.0, R97.1, R97.20, and R97.21. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established.

Code Identity

ICD-10-CM Code
R97
Billable Status
No — Non-Billable Category
Code Describes
Abnormal tumor markers
Short Description
Abnormal tumor markers
Same as the full description in the CMS dataset.
Chapter
R97
Abnormal tumor markers

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR97Abnormal tumor markers
CategoryR97Abnormal tumor markers
This CodeR97Abnormal tumor markers

Specific Coding for Abnormal tumor markersOverview

Non-specific codes like R97 require more characters. Use one of these billable codes instead:

  • Use R97.0 for Elevated carcinoembryonic antigen [CEA]

  • Use R97.1 for Elevated cancer antigen 125 [CA 125]

  • R97.2 for Elevated prostate specific antigen [PSA]

  • Use R97.20 for Elevated prostate specific antigen [PSA]

  • Use R97.21 for Rising PSA following treatment for malignant neoplasm of prostate

  • Use R97.8 for Other abnormal tumor markers

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Elevated tumor associated antigens TAA
  • Elevated tumor specific antigens TSA

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R97Overview

Is R97 (Abnormal tumor markers) a billable code?

No. This is a category header that groups the codes for abnormal tumor markers, and headers cannot be submitted on claims. Claims for abnormal tumor markers need a more specific code from this category, such as R97.0, R97.1, and R97.20.

Can R97 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the abnormal tumor markers is established, that condition takes the principal position instead.