2027 ICD-10-CM Diagnosis Code R82.5Elevated urine levels of drugs, medicaments and biological substances
ICD-10-CM Codes›R00–R99›R80-R82›R82
- Billable — Valid for Submission
- Not Chronic
R82.5 is a billable ICD-10-CM diagnosis code for elevated urine levels of drugs, medicaments and biological substances. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 695 through 696. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Genitourinary signs and symptoms.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- 17-ketogenic steroids level above reference range
- 17-ketogenic steroids outside reference range
- 17-ketosteroids level above reference range
- 17-ketosteroids outside reference range
- Acetaminophen in urine
- Amphetamine in urine
- Epinephrine level above reference range
- High 17-ketosteroid level in urine
- High catecholamine level in urine
- High indoleacetic acid level in urine
- Imipramine in urine
- Lactosuria
- Lipiduria
- Mannoheptulosuria
- Methadone detected in urine
- Norepinephrine level above reference range
- Paraquat in urine
- Phenothiazine in urine
- Porphobilinogen in urine - finding
- Porphyrins in urine - finding
- Urine 17 ketogenic steroid above reference range
- Urine 17 ketogenic steroid level outside reference range
- Urine adrenalin above reference range
- Urine adrenalin level outside reference range
- Urine norepinephrine above reference range
- Urine norepinephrine level outside reference range
- Urine novel psychoactive substance detected
- Urine urate outside reference range
- Urine vanillylmandelic acid above reference range
- Vanillylmandelic acid level above reference range
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to R82.5: its own notes plus those printed at R82, block R80-R82, and Chapter 18. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- chromoabnormalities in urine
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Elevated urine levels of catecholamines
- Elevated urine levels of indoleacetic acid
- Elevated urine levels of 17-ketosteroids
- Elevated urine levels of steroids
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Notes
General instructions on how these codes are used.
- This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
- Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
- The conditions and signs or symptoms included in categories R00-R94 consist of:
- (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
- (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
- (c) provisional diagnosis in a patient who failed to return for further investigation or care;
- (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
- (e) cases in which a more precise diagnosis was not available for any other reason;
- (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name R82.5, its category, or a range that includes it.
Excludes2 1
These codes carry an Excludes2 note naming R82.5: its condition is not part of those codes, and both may be reported when the patient has both.
- Block R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Abnormal, abnormality, abnormalities See Also: Anomaly;
drugs R82.5
indoleacetic acid R82.5
catecholamine R82.5
indoleacetic acid R82.5
17-ketosteroids R82.5
steroids R82.5
Findings, abnormal, inconclusive, without diagnosis See Also: Abnormal;
catecholamines R82.5
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Urine and Urination
Your kidneys make urine by filtering wastes and extra water from your blood. The waste is called urea. Your blood carries it to the kidneys. From the kidneys, urine travels down two thin tubes called ureters to the bladder. The bladder stores urine until you are ready to urinate.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert R82.5 to ICD-9-CMHistory
Code HistoryHistory
Questions About R82.5Overview
What is the ICD-10 code for elevated urine levels of drugs, medicaments and biological substances?
The ICD-10-CM code for elevated urine levels of drugs, medicaments and biological substances is R82.5 (sometimes written as R825). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is R82.5 (Other and unspecified abnormal findings in urine) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report elevated urine levels of drugs, medicaments and biological substances on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does R82.5 group to?
When elevated urine levels of drugs, medicaments and biological substances is the principal diagnosis on an inpatient stay, it groups to MS-DRG 696, 695, with relative weights from 0.6677 to 1.1136 depending on complications. Higher weights mean higher Medicare reimbursement.
Can R82.5 be a principal diagnosis?
Use it with care. This is a symptom code, so once a definitive diagnosis explaining the elevated urine levels of drugs, medicaments and biological substances is established, that condition takes the principal position instead.
Can R82.5 be reported with a code from O28?
Not as a rule. The Excludes1 note at block R80-R82, which applies to R82.5, lists "abnormal findings on antenatal screening of mother (O28.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
