2026 ICD-10-CM Diagnosis Code R82.3Hemoglobinuria

ICD-10-CM Codes›R00–R99›R80-R82›R82

ICD-10-CM R82.3
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

R82.3 is a billable ICD-10-CM diagnosis code for hemoglobinuria. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 695 through 696. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as acquired hemoglobinopathy. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Genitourinary signs and symptoms.

Code Identity

ICD-10-CM Code
R82.3
Billable Status
Yes — Valid for Submission
Code Describes
Hemoglobinuria
Short Description
Hemoglobinuria
Same as the full description in the CMS dataset.
Parent Code
R82
Other and unspecified abnormal findings in urine

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR80-R82Abnormal findings on examination of urine, without diagnosis
CategoryR82Other and unspecified abnormal findings in urine
This CodeR82.3Hemoglobinuria

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired hemoglobinopathy
  • Acquired methemoglobinuria
  • Carboxyhemoglobinuria
  • Hemoglobinuria
  • Methemoglobinuria
  • Postparturient hemoglobinuria
  • Sulfhemoglobinuria

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • hemoglobinuria due to hemolysis from external causes NEC D59.6
  • hemoglobinuria due to paroxysmal nocturnal Marchiafava-Micheli D59.5

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Abnormal, abnormality, abnormalities
      • urine (constituents)
        • hemoglobin
    • Findings, abnormal, inconclusive, without diagnosis
      • hematinuria
    • Findings, abnormal, inconclusive, without diagnosis
      • hemoglobinuria
    • Findings, abnormal, inconclusive, without diagnosis
      • urine
        • hemoglobin
    • Globinuria
    • Hemoglobinuria

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM011
Genitourinary signs and symptoms
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hemoglobinuria

    the presence of free hemoglobin in the urine, indicating hemolysis of erythrocytes within the vascular system. after saturating the hemoglobin-binding proteins (haptoglobins), free hemoglobin begins to appear in the urine.

  • Hemoglobinuria, Paroxysmal

    a condition characterized by the recurrence of hemoglobinuria caused by intravascular hemolysis. in cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. in cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

  • Hemoglobinuria, CTCAE|Hemoglobinuria|Hemoglobinuria|Hemoglobinuria, CTCAE 5.0

    a disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.

  • Blackwater Fever|Malarial Hemoglobinuria

    a complication of malaria resulting from hemolysis.

  • Grade 1 Hemoglobinuria, CTCAE|Grade 1 Hemoglobinuria|Grade 1 Hemoglobinuria

    asymptomatic; clinical or diagnostic observations only; intervention not indicated

  • Hemoglobinuria

    a laboratory test result which indicates free hemoglobin in the urine.

  • Hemoglobinuria due to Hemolysis from External Causes

    hemoglobin in the urine that is due to hemolysis from an external cause.

  • Hemoglobinuria, CTCAE 5.0|Hemoglobinuria|Hemoglobinuria

    a disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.

  • Paroxysmal Nocturnal Hemoglobinuria|PNH|PNH|Paroxysmal Hemoglobinuria|paroxysmal nocturnal hemoglobinuria

    a rare acquired hematologic disorder characterized by hemolytic anemia, dark-colored urine due to the release of hemoglobin in the blood, and thrombosis. the episodes of hemolysis tend to occur at night. it is caused by a somatic mutation in the glycosylphosphatidylinositol biosynthesis gene.

  • PIGA Gene Mutation|GPI3 Gene Mutation|MCAHS2 Gene Mutation|PIG-A Gene Mutation|PNH1 Gene Mutation|Paroxysmal Nocturnal Hemoglobinuria Gene Mutation|Phosphatidylinositol Glycan Anchor Biosynthesis Class A Gene Mutation

    a change in the nucleotide sequence of the piga gene.

  • PIGA wt Allele|GPI3|MCAHS2|PIG-A|PNH1|Paroxysmal Nocturnal Hemoglobinuria Gene|Phosphatidylinositol Glycan Anchor Biosynthesis Class A wt Allele|Phosphatidylinositol Glycan Anchor Biosynthesis, Class A Gene|Phosphatidylinositol Glycan, Class A (Paroxysmal Nocturnal Hemoglobinuria) Gene

    human piga wild-type allele is located in the vicinity of xp22.1 and is approximately 16 kb in length. this allele, which encodes phosphatidylinositol n-acetylglucosaminyltransferase subunit a protein, plays a role in the modulation of protein lipidation. mutation of the gene is associated with paroxysmal nocturnal hemoglobinuria.

Patient EducationClinical

Urine and Urination

Your kidneys make urine by filtering wastes and extra water from your blood. The waste is called urea. Your blood carries it to the kidneys. From the kidneys, urine travels down two thin tubes called ureters to the bladder. The bladder stores urine until you are ready to urinate.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R82.3 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
791.2 Hemoglobinuria
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About R82.3Overview

Is R82.3 (Other and unspecified abnormal findings in urine) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hemoglobinuria on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does R82.3 group to?

When hemoglobinuria is the principal diagnosis on an inpatient stay, it groups to MS-DRG 695, 696, with relative weights from 0.6890 to 1.1438 depending on complications. Higher weights mean higher Medicare reimbursement.

Can R82.3 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the hemoglobinuria is established, that condition takes the principal position instead.

What is the ICD-9 equivalent of R82.3?

Under the General Equivalence Mappings, hemoglobinuria converts to ICD-9-CM 791.2 (hemoglobinuria). The mapping is a direct match.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.