2027 ICD-10-CM Diagnosis Code R45.3Demoralization and apathy

ICD-10-CM Codes›R00–R99›R40-R46›R45

ICD-10-CM R45.3
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

R45.3 is a billable ICD-10-CM diagnosis code for demoralization and apathy. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 880. As a symptom code, it should not be used as a principal diagnosis once a related definitive diagnosis has been established. Coders also document this condition as demoralization. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Symptoms of mental and substance use conditions.

Code Identity

ICD-10-CM Code
R45.3
Billable Status
Yes — Valid for Submission
Code Describes
Demoralization and apathy
Short Description
Demoralization and apathy
Same as the full description in the CMS dataset.
Parent Code
R45
Symptoms and signs involving emotional state

Code Classification

ChapterR00–R99Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
SectionR40-R46Symptoms and signs involving cognition, perception, emotional state and behavior
CategoryR45Symptoms and signs involving emotional state
This CodeR45.3Demoralization and apathy

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Demoralization
  • Indifference
  • Lack of emotional response

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to R45.3: its own notes plus those printed at block R40-R46 and Chapter 18. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block R40-R46 Symptoms and signs involving cognition, perception, emotional state and behavior applies to 157 codes
  • symptoms and signs constituting part of a pattern of mental disorder (F01-F99)
From Chapter 18 (R00-R99) Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified applies to 774 codes
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)

Notes

General instructions on how these codes are used.

From Chapter 18 (R00-R99) Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified applies to 774 codes
  • This chapter includes symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
  • Signs and symptoms that point rather definitely to a given diagnosis have been assigned to a category in other chapters of the classification. In general, categories in this chapter include the less well-defined conditions and symptoms that, without the necessary study of the case to establish a final diagnosis, point perhaps equally to two or more diseases or to two or more systems of the body. Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'. The Alphabetical Index should be consulted to determine which symptoms and signs are to be allocated here and which to other chapters. The residual subcategories, numbered .8, are generally provided for other relevant symptoms that cannot be allocated elsewhere in the classification.
  • The conditions and signs or symptoms included in categories R00-R94 consist of:
  • (a) cases for which no more specific diagnosis can be made even after all the facts bearing on the case have been investigated;
  • (b) signs or symptoms existing at the time of initial encounter that proved to be transient and whose causes could not be determined;
  • (c) provisional diagnosis in a patient who failed to return for further investigation or care;
  • (d) cases referred elsewhere for investigation or treatment before the diagnosis was made;
  • (e) cases in which a more precise diagnosis was not available for any other reason;
  • (f) certain symptoms, for which supplementary information is provided, that represent important problems in medical care in their own right.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name R45.3, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming R45.3: they are not reported together with it, unless the two conditions are unrelated.

  • F07.0 Personality change due to known physiological condition
    signs and symptoms involving emotional state (R45.-) names R45.-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR SYM008
Symptoms of mental and substance use conditions
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Depression

Depression is more than a feeling of being sad or irritable for a few days. It's a serious mood disorder. As one of the most common mental disorders in the United States, depression can affect how you think, feel, and your everyday life.

The full article covers:

  • What is depression?
  • What are the different types of depression?
  • What causes depression?
  • Who is at risk of depression?
  • What are the symptoms of depression?
  • How is depression diagnosed?
  • What are the treatments for depression?
  • Can depression be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert R45.3 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
799.25 Demoralization & apathy
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About R45.3Overview

What is the ICD-10 code for demoralization and apathy?

The ICD-10-CM code for demoralization and apathy is R45.3 (sometimes written as R453). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is R45.3 (Symptoms and signs involving emotional state) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report demoralization and apathy on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does R45.3 group to?

When demoralization and apathy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 880 (acute Adjustment Reaction and Psychosocial Dysfunction), which carries a relative weight of 0.9306. Higher weights mean higher Medicare reimbursement.

Can R45.3 be a principal diagnosis?

Use it with care. This is a symptom code, so once a definitive diagnosis explaining the demoralization and apathy is established, that condition takes the principal position instead.

Can R45.3 be reported with R45.84?

Not as a rule. The Excludes1 note on R45.3 lists "anhedonia (R45.84)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).