2027 ICD-10-CM Diagnosis Code N46.021Azoospermia due to drug therapy

ICD-10-CM Codes›N00–N99›N40-N53›N46

ICD-10-CM N46.021
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

N46.021 is a billable ICD-10-CM diagnosis code for azoospermia due to drug therapy. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 729 through 730. The code is restricted by the Medicare Code Editor to adult patients (age 15 through 124). Coders also document this condition as azoospermia caused by chemotherapy. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Male infertility.

Code Identity

ICD-10-CM Code
N46.021
Billable Status
Yes — Valid for Submission
Code Describes
Azoospermia due to drug therapy
Short Description
Azoospermia due to drug therapy
Same as the full description in the CMS dataset.
Parent Code
N46.02
Azoospermia due to extratesticular causes

Code Classification

ChapterN00–N99Diseases of the genitourinary system
SectionN40-N53Diseases of male genital organs
CategoryN46Male infertility
This CodeN46.021Azoospermia due to drug therapy

Code EditsBilling

Medicare Code Editor checks that affect claim validity for N46.021.

Adult diagnoses
The Medicare Code Editor detects inconsistencies in adult cases by checking a patient's age and any diagnosis on the patient's record. The adult code edits apply to patients age range is 15–124 years inclusive (e.g., senile delirium, mature cataract).

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Azoospermia caused by chemotherapy
  • Azoospermia caused by drug
  • Induced spermatogenic arrest
  • Spermatogenic arrest

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to N46.021: its own notes plus those printed at N46.02, N46, and Chapter 14. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From N46 Male infertility applies to 16 codes

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Chapter 14 (N00-N99) Diseases of the genitourinary system applies to 838 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Code Also

A second code may be needed to fully describe the condition; the note gives no sequencing direction.

From N46.02 Azoospermia due to extratesticular causes applies to 6 codes
  • associated cause

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name N46.021, its category, or a range that includes it.

Excludes1 3

These codes carry an Excludes1 note naming N46.021: they are not reported together with it, unless the two conditions are unrelated.

  • R86 Abnormal findings in specimens from male genital organs
    azoospermia (N46.0-) names N46.0-, which includes this code
  • Z98.5 Sterilization status
    male infertility (N46.-) names N46.-, which includes this code
  • E29 Testicular dysfunction
    azoospermia or oligospermia NOS (N46.0-N46.1) names N46.0-N46.1, which includes this code

Excludes2 1

These codes carry an Excludes2 note naming N46.021: its condition is not part of those codes, and both may be reported when the patient has both.

  • Z31 Encounter for procreative management
    male infertility (N46.-) names N46.-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient No · outpatient No
CCSR GEN015
Male infertility
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Azoospermia

    a condition of having no sperm present in the ejaculate (semen).

Patient EducationClinical

Drug Reactions

Most of the time, medicines make our lives better. They reduce aches and pains, fight infections, and control problems such as high blood pressure or diabetes. But medicines can also cause unwanted reactions, such as drug interactions, side effects, and allergies.

The full article covers:

  • What is a drug interaction?
  • What are side effects?
  • What are drug allergies?
  • How can I stay safe when taking medicines?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert N46.021 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
606.0 Azoospermia
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About N46.021Overview

What is the ICD-10 code for azoospermia due to drug therapy?

The ICD-10-CM code for azoospermia due to drug therapy is N46.021 (sometimes written as N46021). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is N46.021 (Azoospermia due to extratesticular causes) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report azoospermia due to drug therapy on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does N46.021 group to?

When azoospermia due to drug therapy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 729, 730, with relative weights from 0.6595 to 1.0553 depending on complications. Higher weights mean higher Medicare reimbursement.

Who can N46.021 be reported for?

The Medicare Code Editor checks azoospermia due to drug therapy against patient demographics: this code is intended for adult patients (age 15 through 124). Claims outside these limits are flagged as inconsistent.

Can N46.021 be reported with Z98.52?

Not as a rule. The Excludes1 note at N46, which applies to N46.021, lists "vasectomy status (Z98.52)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).