2026 ICD-10-CM Diagnosis Code N25.1Nephrogenic diabetes insipidus

ICD-10-CM Codes›N00–N99›N25-N29›N25

ICD-10-CM N25.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

N25.1 is a billable ICD-10-CM diagnosis code for nephrogenic diabetes insipidus. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 698 through 700. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified diseases of kidney and ureters.

Code Identity

ICD-10-CM Code
N25.1
Billable Status
Yes — Valid for Submission
Code Describes
Nephrogenic diabetes insipidus
Short Description
Nephrogenic diabetes insipidus
Same as the full description in the CMS dataset.
Parent Code
N25
Disorders resulting from impaired renal tubular function

Code Classification

ChapterN00–N99Diseases of the genitourinary system
SectionN25-N29Other disorders of kidney and ureter
CategoryN25Disorders resulting from impaired renal tubular function
This CodeN25.1Nephrogenic diabetes insipidus

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired vasopressin resistance
  • Autosomal dominant vasopressin resistance
  • Autosomal hereditary vasopressin resistance
  • Autosomal recessive vasopressin resistance
  • Hereditary vasopressin resistance
  • Hereditary vasopressin-related polyuria
  • Partial vasopressin resistance
  • Partial vasopressin-related polyuria
  • Schofer Beetz Bohl syndrome
  • Secondary vasopressin resistance
  • Secondary vasopressin-related polyuria
  • Vasopressin resistance
  • X-linked hereditary vasopressin resistance

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Type 1 Excludes

  • diabetes insipidus NOS E23.2

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Diabetes, diabetic(mellitus) (sugar)
      • insipidus
        • nephrogenic
    • Diabetes, diabetic(mellitus) (sugar)
      • insipidus
        • vasopressin resistant

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR GEN006
Other specified and unspecified diseases of kidney and ureters
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • AVPR2 wt Allele|ADHR|Arginine Vasopressin Receptor 2 (Nephrogenic Diabetes Insipidus) Gene|Arginine Vasopressin Receptor 2 wt Allele|DI1|DIR|DIR3|NDI|V2R

    human avpr2 wild-type allele is located within xq28 and is approximately 5 kb in length. this allele, which encodes vasopressin v2 receptor protein, is involved in the maintenance of water homeostasis and g protein-coupled receptor signal transduction. when the function of the gene is absent, it results in nephrogenic diabetes insipidus (ndi).

  • Nephrogenic Diabetes Insipidus

    diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone.

Patient EducationClinical

Diabetes Insipidus

Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This cycle can keep you from sleeping or even make you wet the bed. Your body produces lots of urine that is almost all water.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert N25.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
588.1 Nephrogen diabetes insip
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About N25.1Overview

Is N25.1 (Disorders resulting from impaired renal tubular function) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report nephrogenic diabetes insipidus on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does N25.1 group to?

When nephrogenic diabetes insipidus is the principal diagnosis on an inpatient stay, it groups to MS-DRG 698, 699, 700, with relative weights from 0.6899 to 1.6544 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of N25.1?

Under the General Equivalence Mappings, nephrogenic diabetes insipidus converts to ICD-9-CM 588.1 (nephrogen diabetes insip). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.