2027 ICD-10-CM Diagnosis Code N25.1Nephrogenic diabetes insipidus
ICD-10-CM Codes›N00–N99›N25-N29›N25
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
N25.1 is a billable ICD-10-CM diagnosis code for nephrogenic diabetes insipidus. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 698 through 700. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 273 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified diseases of kidney and ureters.
N25.1 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
N25.1 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acquired vasopressin resistance
- Autosomal dominant vasopressin resistance
- Autosomal hereditary vasopressin resistance
- Autosomal recessive vasopressin resistance
- Hereditary vasopressin resistance
- Hereditary vasopressin-related polyuria
- Partial vasopressin resistance
- Partial vasopressin-related polyuria
- Schofer Beetz Bohl syndrome
- Secondary vasopressin resistance
- Secondary vasopressin-related polyuria
- Vasopressin resistance
- X-linked hereditary vasopressin resistance
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to N25.1: its own notes plus those printed at block N25-N29 and Chapter 14. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- diabetes insipidus NOS (E23.2)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name N25.1, its category, or a range that includes it.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Diabetes Insipidus, Nephrogenic
a genetic or acquired polyuric disorder characterized by persistent hypotonic urine and hypokalemia. this condition is due to renal tubular insensitivity to vasopressin and failure to reduce urine volume. it may be the result of mutations of genes encoding vasopressin receptors or aquaporin-2; kidney diseases; adverse drug effects; or complications from pregnancy.
Patient EducationClinical
Diabetes Insipidus
Diabetes insipidus (DI) causes frequent urination. You become extremely thirsty, so you drink. Then you urinate. This cycle can keep you from sleeping or even make you wet the bed. Your body produces lots of urine that is almost all water.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert N25.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About N25.1Overview
What is the ICD-10 code for nephrogenic diabetes insipidus?
The ICD-10-CM code for nephrogenic diabetes insipidus is N25.1 (sometimes written as N251). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is N25.1 (Disorders resulting from impaired renal tubular function) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report nephrogenic diabetes insipidus on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does N25.1 group to?
When nephrogenic diabetes insipidus is the principal diagnosis on an inpatient stay, it groups to MS-DRG 699, 698, 700, with relative weights from 0.6740 to 1.6400 depending on complications. Higher weights mean higher Medicare reimbursement.
Is N25.1 a CC or MCC?
CMS lists N25.1 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 273 closely related codes in its exclusion list.
Can N25.1 be reported with E23.2?
Not as a rule. The Excludes1 note on N25.1 lists "diabetes insipidus NOS (E23.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does N25.1 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. N25.1 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
