2027 ICD-10-CM Diagnosis Code M46.35Infection of intervertebral disc (pyogenic), thoracolumbar region
ICD-10-CM Codes›M00–M99›M45-M49›M46
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 92
- Not Chronic
M46.35 is a billable ICD-10-CM diagnosis code for infection of intervertebral disc (pyogenic), thoracolumbar region. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 456 through 458, 539 through 541. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 221 closely related codes. Coders also document this condition as infection of intervertebral disc - pyogenic. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Spondylopathies/spondyloarthropathy (including infective).
For Medicare Advantage risk adjustment, M46.35 maps to CMS-HCC Category 92 (Bone/Joint/Muscle/Severe Soft Tissue Infections/Necrosis) under the V28 model, adding a risk factor of about 0.479 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
M46.35 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Infection of intervertebral disc - pyogenic
- Lumbar discitis
- Pyogenic infection of lumbar intervertebral disc
- Pyogenic infection of thoracic intervertebral disc
- Pyogenic infection of thoracolumbar intervertebral disc
- Thoracic discitis
- Thoracolumbar disc disorder
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to M46.35: its own notes plus those printed at M46.3 and Chapter 13. A note printed at a category, block or chapter applies to every code under it.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- arthropathic psoriasis (L40.5-)
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- compartment syndrome (traumatic) (T79.A-)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Notes
General instructions on how these codes are used.
- Use an external cause code following the code for the musculoskeletal condition, if applicable, to identify the cause of the musculoskeletal condition
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name M46.35, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming M46.35: they are not reported together with it, unless the two conditions are unrelated.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Spine Injuries and Disorders
Your backbone, or spine, is made up of 26 bone discs called vertebrae. The vertebrae protect your spinal cord and allow you to stand and bend. A number of problems can change the structure of the spine or damage the vertebrae and surrounding tissue. They include:
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert M46.35 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About M46.35Overview
What is the ICD-10 code for infection of intervertebral disc (pyogenic), thoracolumbar region?
The ICD-10-CM code for infection of intervertebral disc (pyogenic), thoracolumbar region is M46.35 (sometimes written as M4635). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is M46.35 (Infection of intervertebral disc (pyogenic)) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report infection of intervertebral disc (pyogenic), thoracolumbar region on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does M46.35 group to?
When infection of intervertebral disc (pyogenic), thoracolumbar region is the principal diagnosis on an inpatient stay, it groups to MS-DRG 541, 456, 457, 539, 540, 458, with relative weights from 0.8293 to 7.6211 depending on complications. Higher weights mean higher Medicare reimbursement.
Is M46.35 a CC or MCC?
CMS lists M46.35 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 221 closely related codes in its exclusion list.
Does M46.35 need an additional code?
When the condition applies, yes. The Use Additional Code note at M46.3, which applies to M46.35, reads: code (B95-B97) to identify infectious agent.. The additional code is reported after M46.35.
What HCC is M46.35?
M46.35 (infection of intervertebral disc (pyogenic), thoracolumbar region) maps to CMS-HCC Category 92 (Bone/Joint/Muscle/Severe Soft Tissue Infections/Necrosis), commonly written as HCC 92, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 39 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. It does not map to any RxHCC in the Part D prescription drug model.
Does M46.35 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, M46.35 adds a risk adjustment factor of about 0.479 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.471 to 0.632 depending on the payment segment). HCC 92 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 92 category page.
