2027 ICD-10-CM Diagnosis Code J10.81Influenza due to other identified influenza virus with encephalopathy

ICD-10-CM Codes›J00–J99›J09-J18›J10

ICD-10-CM J10.81
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

J10.81 is a billable ICD-10-CM diagnosis code for influenza due to other identified influenza virus with encephalopathy. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 865 through 866. Coders also document this condition as encephalopathy caused by Influenza A virus. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Influenza and Other nervous system disorders (neither hereditary nor degenerative).

Code Identity

ICD-10-CM Code
J10.81
Billable Status
Yes — Valid for Submission
Code Describes
Influenza due to other identified influenza virus with encephalopathy
Short Description
Influenza due to oth ident influenza virus w encephalopathy
Parent Code
J10.8
Influenza due to other identified influenza virus with other manifestations

Code Classification

ChapterJ00–J99Diseases of the respiratory system
SectionJ09-J18Influenza and pneumonia
CategoryJ10Influenza due to other identified influenza virus
This CodeJ10.81Influenza due to other identified influenza virus with encephalopathy

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Encephalopathy caused by Influenza A virus
  • Encephalopathy caused by Influenza A virus subtype H1N1

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to J10.81: its own notes plus those printed at J10, block J09-J18, and Chapter 10. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From J10 Influenza due to other identified influenza virus applies to 9 codes
  • influenza A (non-novel)
  • influenza B
  • influenza C

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From J10 Influenza due to other identified influenza virus applies to 9 codes
  • influenza due to avian influenza virus (J09.X-)
  • influenza due to swine flu (J09.X-)
  • influenza due to unidentifed influenza virus (J11.-)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From Block J09-J18 Influenza and pneumonia applies to 53 codes
  • allergic or eosinophilic pneumonia (J82)
  • aspiration pneumonia NOS (J69.0)
  • meconium pneumonia (P24.01)
  • neonatal aspiration pneumonia (P24.-)
  • pneumonia due to solids and liquids (J69.-)
  • congenital pneumonia (P23.9)
  • lipid pneumonia (J69.1)
  • rheumatic pneumonia (I00)
  • ventilator associated pneumonia (J95.851)
From Chapter 10 (J00-J99) Diseases of the respiratory system applies to 366 codes
  • certain conditions originating in the perinatal period (P04-P96)
  • certain infectious and parasitic diseases (A00-B99)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • smoke inhalation (T59.81-)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

From Block J09-J18 Influenza and pneumonia applies to 53 codes
  • code, if applicable, to identify resistance to antimicrobial drugs (Z16.-)
From Chapter 10 (J00-J99) Diseases of the respiratory system applies to 366 codes
  • code, where applicable, to identify:
  • exposure to environmental tobacco smoke (Z77.22)
  • exposure to tobacco smoke in the perinatal period (P96.81)
  • history of tobacco dependence (Z87.891)
  • occupational exposure to environmental tobacco smoke (Z57.31)
  • tobacco dependence (F17.-)
  • tobacco use (Z72.0)

Notes

General instructions on how these codes are used.

From Chapter 10 (J00-J99) Diseases of the respiratory system applies to 366 codes
  • When a respiratory condition is described as occurring in more than one site and is not specifically indexed, it should be classified to the lower anatomic site (e.g. tracheobronchitis to bronchitis in J40).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name J10.81, its category, or a range that includes it.

Applicable To 1

These notes mention J10.81.

  • P00.2 Newborn affected by maternal infectious and parasitic diseases
    Newborn affected by maternal infectious disease classifiable to A00-B99, J09 and J10 names J10, which includes this code

Excludes1 4

These codes carry an Excludes1 note naming J10.81: they are not reported together with it, unless the two conditions are unrelated.

  • G94 Other disorders of brain in diseases classified elsewhere
    encephalopathy in influenza (J09.X9, J10.81, J11.81)
  • J09 Influenza due to certain identified influenza viruses
    influenza A/H1N1 (J10.-) names J10.-, which includes this code
  • J09 Influenza due to certain identified influenza viruses
    influenza due to other identified influenza virus (J10.-) names J10.-, which includes this code
  • J09 Influenza due to certain identified influenza viruses
    seasonal influenza due to other identified influenza virus (J10.-) names J10.-, which includes this code

Excludes2 1

These codes carry an Excludes2 note naming J10.81: its condition is not part of those codes, and both may be reported when the patient has both.

  • Block P35-P39 Infections specific to the perinatal period
    infectious diseases not specific to the perinatal period (A00-B99, J09, J10.-) names J10.-, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR RSP003
Influenza
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR NVS020
Other nervous system disorders (neither hereditary nor degenerative)
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Flu

The flu, also called influenza, is a respiratory infection caused by viruses. Each year, millions of Americans get sick with the flu. Sometimes it causes mild illness. But it can also be serious or even deadly, especially for people over 65, newborn babies, and people with certain chronic illnesses.

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Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert J10.81 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
487.8 Flu w manifestation NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About J10.81Overview

What is the ICD-10 code for influenza due to other identified influenza virus with encephalopathy?

The ICD-10-CM code for influenza due to other identified influenza virus with encephalopathy is J10.81 (sometimes written as J1081). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is J10.81 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report influenza due to other identified influenza virus with encephalopathy on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does J10.81 group to?

When influenza due to other identified influenza virus with encephalopathy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 866, 865, with relative weights from 0.8691 to 1.3153 depending on complications. Higher weights mean higher Medicare reimbursement.

Can J10.81 be reported with a code from J09.X?

Not as a rule. The Excludes1 note at J10, which applies to J10.81, lists "influenza due to avian influenza virus (J09.X-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of J10.81?

Under the General Equivalence Mappings, influenza due to other identified influenza virus with encephalopathy converts to ICD-9-CM 487.8 (flu w manifestation NEC). The mapping is approximate, so confirm the match fits the documentation.