2026 ICD-10-CM Diagnosis Code E85.82Wild-type transthyretin-related (ATTR) amyloidosis
ICD-10-CM Codes›E00–E89›E70-E88›E85
- Billable — Valid for Submission
- Chronic Condition
E85.82 is a billable ICD-10-CM diagnosis code for wild-type transthyretin-related (ATTR) amyloidosis. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 545 through 547. Coders also document this condition as age-related amyloidosis. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Age-related amyloidosis
- Cardiac familial non-neuropathic amyloidosis
- Familial cardiomyopathy
- Familial non-neuropathic amyloidosis
- Familial restrictive cardiomyopathy
- Hereditary ATTR amyloidosis
- Infiltrative cardiomyopathy
- Transthyretin related familial amyloid cardiomyopathy
- Wild type ATTR amyloidosis
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Senile systemic amyloidosis (SSA)
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Amyloidosis (generalized) (primary) - E85.9
- senile systemic (SSA) - E85.82
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Amyloidosis(generalized) (primary)
- senile systemic (SSA)
- Amyloidosis(generalized) (primary)
- wild-type transthyretin-related (ATTR)
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Myocardial Degeneration
degeneration of myocardial tissue.
Patient EducationClinical
Transthyretin amyloidosis
Transthyretin amyloidosis is a progressive condition characterized by the buildup of abnormal protein deposits called amyloids (amyloidosis) in the body's organs and tissues.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E85.82 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code History & ChangesHistory
Replacement E85.82 replaces the following previously assigned code(s):
- E85.8 - Other amyloidosis
Questions About E85.82Overview
Is E85.82 (Other amyloidosis) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report wild-type transthyretin-related (ATTR) amyloidosis on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E85.82 group to?
When wild-type transthyretin-related (ATTR) amyloidosis is the principal diagnosis on an inpatient stay, it groups to MS-DRG 545, 546, 547, with relative weights from 0.8362 to 2.4817 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E85.82?
Under the General Equivalence Mappings, wild-type transthyretin-related (ATTR) amyloidosis converts to ICD-9-CM 277.39 (amyloidosis NEC). The mapping is approximate, so confirm the match fits the documentation.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
