2026 ICD-10-CM Diagnosis Code E11.21Type 2 diabetes mellitus with diabetic nephropathy

ICD-10-CM Codes›E00–E89›E08-E13›E11

ICD-10-CM E11.21
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E11.21 is a billable ICD-10-CM diagnosis code for type 2 diabetes mellitus with diabetic nephropathy. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 698 through 700. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diabetes mellitus with complication; Diabetes mellitus, Type 2; and Nephritis; nephrosis; renal sclerosis.

This medical diagnosis code is frequently used in Family Practice medical specialties to designate conditions such diabetes mellitus with complications type 2.

Code Identity

ICD-10-CM Code
E11.21
Billable Status
Yes — Valid for Submission
Code Describes
Type 2 diabetes mellitus with diabetic nephropathy
Short Description
Type 2 diabetes mellitus with diabetic nephropathy
Same as the full description in the CMS dataset.
Parent Code
E11.2
Type 2 diabetes mellitus with kidney complications

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE08-E13Diabetes mellitus
CategoryE11Type 2 diabetes mellitus
This CodeE11.21Type 2 diabetes mellitus with diabetic nephropathy

Quality Payment Program MeasuresBilling

Medicare quality measures that can apply when E11.21 is part of the patient record.

Diabetes: Hemoglobin A1c (HbA1c) Poor Control (>9%)

High Priority: YES

Measure Type: Intermediateoutcome

Submission Methods: Claims, Electronic Health Record, Cms Web Interface, Registry

Description: Percentage of patients 18-75 years of age with diabetes who had hemoglobin A1c > 9.0% during the measurement period.

View Measure

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Armanni-Ebstein kidney
  • Armanni-Ebstein kidney due to diabetes mellitus
  • Diabetic glomerulonephritis
  • Diffuse glomerulosclerosis of kidney due to diabetes mellitus
  • Disorder of kidney due to diabetes mellitus
  • Glomerulopathy due to diabetes mellitus
  • Glomerulosclerosis of kidney due to diabetes mellitus
  • Intracapillary glomerulosclerosis of kidney due to diabetes mellitus
  • Kimmelstiel-Wilson syndrome
  • Macroalbuminuric nephropathy due to diabetes mellitus
  • Microalbuminuria
  • Microalbuminuric diabetic nephropathy
  • Nephrotic syndrome due to diabetes mellitus
  • Nephrotic syndrome due to type 2 diabetes mellitus
  • Nodular type diabetic glomerulosclerosis
  • Pregestational diabetes mellitus AND/OR impaired glucose tolerance, modified White class F
  • Proteinuria due to type 2 diabetes mellitus
  • Proteinuric nephropathy due to diabetes mellitus
  • Renal disorder due to type 2 diabetes mellitus
  • Serum albumin below reference range

Coding GuidelinesGuidance

The diabetes mellitus codes are combination codes that include the type of diabetes mellitus, the body system affected, and the complications affecting that body system. As many codes within a particular category as are necessary to describe all of the complications of the disease may be used. They should be sequenced based on the reason for a particular encounter. Assign as many codes from categories E08 - E13 as needed to identify all of the associated conditions that the patient has.

If the type of diabetes mellitus is not documented in the medical record the default is E11.-, Type 2 diabetes mellitus.

Source: ICD-10-CM Official Guidelines for Coding and Reporting, FY 2026, published by CMS and the National Center for Health Statistics.

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Type 2 diabetes mellitus with intercapillary glomerulosclerosis
  • Type 2 diabetes mellitus with intracapillary glomerulonephrosis
  • Type 2 diabetes mellitus with Kimmelstiel-Wilson disease

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Diabetes, diabetic(mellitus) (sugar)
      • with
        • glomerulonephrosis, intracapillary
    • Diabetes, diabetic(mellitus) (sugar)
      • with
        • glomerulosclerosis, intercapillary
    • Diabetes, diabetic(mellitus) (sugar)
      • with
        • Kimmelstiel-Wilson disease
    • Diabetes, diabetic(mellitus) (sugar)
      • with
        • nephropathy
    • Diabetes, diabetic(mellitus) (sugar)
      • type 2
        • with
          • glomerulonephrosis, intracapillary
    • Diabetes, diabetic(mellitus) (sugar)
      • type 2
        • with
          • glomerulosclerosis, intercapillary
    • Diabetes, diabetic(mellitus) (sugar)
      • type 2
        • with
          • Kimmelstiel-Wilson disease
    • Diabetes, diabetic(mellitus) (sugar)
      • type 2
        • with
          • nephropathy

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END003
Diabetes mellitus with complication
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR END005
Diabetes mellitus, Type 2
Default principal diagnosis: inpatient No · outpatient No
CCSR GEN001
Nephritis; nephrosis; renal sclerosis
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Diabetes Type 2

Type 2 diabetes is a disease in which your blood glucose, or blood sugar, levels are too high. Glucose is your main source of energy. It comes from the foods you eat. A hormone called insulin helps the glucose get into your cells to give them energy. If you have diabetes, your body doesn't make enough insulin or doesn't use insulin well.

The full article covers:

  • What is type 2 diabetes?
  • What causes type 2 diabetes?
  • Who is at risk for type 2 diabetes?
  • What are the symptoms of type 2 diabetes?
  • How is type 2 diabetes diagnosed?
  • What are the treatments for type 2 diabetes?
  • Can type 2 diabetes be prevented?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E11.21 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
250.40 DMII renl nt st uncntrld
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E11.21Overview

Is E11.21 (Type 2 diabetes mellitus with kidney complications) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report type 2 diabetes mellitus with diabetic nephropathy on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E11.21 group to?

When type 2 diabetes mellitus with diabetic nephropathy is the principal diagnosis on an inpatient stay, it groups to MS-DRG 698, 699, 700, with relative weights from 0.6899 to 1.6544 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E11.21?

Under the General Equivalence Mappings, type 2 diabetes mellitus with diabetic nephropathy converts to ICD-9-CM 250.40 (DMII renl nt st uncntrld). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.